Influence of the ABO Blood Type on the Platelet Function Analyzer PFA-100

Lippi, Giuseppe; Franchini, Marco; Brocco, G.; Manzato, Franco

doi:10.1055/s-0037-1615707

Cited by 33 publications

(2 citation statements)

References 2 publications

(6 reference statements)

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“…Furthermore, coagulation factor VIII activity is reported to be low in blood group O 23 , 24 . Additionally, platelet function, as analyzed using PFA-100 25 , is also reduced in individuals with blood group O. These findings provide a theoretical explanation for the diminished hemostatic capacity observed in individuals with blood group O.…”

Section: Discussionmentioning

confidence: 68%

Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study

Suzuki,

Tominaga,

Aoki

et al. 2024

Sci Rep

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The relationship between blood group and rebleeding in acute lower gastrointestinal bleeding (ALGIB) remains unclear. This study aimed to investigate the association between blood group O and clinical outcomes in patients with ALGIB. The study included 2336 patients with ALGIB whose bleeding source was identified during initial endoscopy (from the CODE BLUE-J Study). The assessed outcomes encompassed rebleeding and other clinical parameters. The rebleeding rates within 30 days in patients with blood group O and those without blood group O were 17.9% and 14.9%, respectively. Similarly, the rates within 1 year were 21.9% for patients with blood group O and 18.2% for those without blood group O. In a multivariate analysis using age, sex, vital signs at presentation, blood test findings, comorbidities, antithrombotic medication, active bleeding, and type of endoscopic treatment as covariates, patients with blood group O exhibited significantly higher risks for rebleeding within 30 days (odds ratio [OR] 1.31; 95% confidence interval [CI] 1.04–1.65; P = 0.024) and 1 year (OR 1.29; 95% CI 1.04–1.61; P = 0.020) compared to those without blood group O. However, the thrombosis and mortality rates did not differ significantly between blood group O and non-O patients. In patients with ALGIB, blood group O has been identified as an independent risk factor for both short- and long-term rebleeding.

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Section: Discussionmentioning

confidence: 68%

Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study

Suzuki,

Tominaga,

Aoki

et al. 2024

Sci Rep

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“…Recent studies have indicated that the ABO blood type has a profound influence on hemostasis. Individuals with blood type O have a longer bleeding time, and lower plasma levels of either factor VIII or von Willebrand factor (vWF) than individuals in with non-O blood types [16,17]; therefore, patients with type O blood have a relatively low incidence of venous thromboembolism compared to patients with non-type O blood [18]. Additionally, platelet function is compromised in the O blood group, which is also associated with a higher bleeding potency [19,20].…”

Section: Objectivesmentioning

confidence: 99%

Association of ABO Blood Type with Bleeding Severity in Patients with Acute Gastroesophageal Variceal Bleeding

et al. 2021

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Background and Objectives: ABO blood types have been implicated as potential risk factors for various hemorrhagic diseases. No study has investigated the association between gastroesophageal variceal bleeding and ABO blood types. We aimed to evaluate the impact of ABO blood types on mortality and bleeding risk in acute gastroesophageal variceal bleeding. Materials and Methods: This is a retrospective observational study. Patients presenting with acute gastroesophageal varices bleeding diagnosed by endoscopy were enrolled, and were divided by blood type into a type O group and non-type O group. The outcomes were death within 30 days and the proportion of further bleeding. We used generalized linear mixed-effects models to analyze the outcomes. Results: A total of 327 patients and 648 records of emergency room visits were included. The 30-day mortality was 14.8% (21 of 142 patients) in the type O group, and 16.2% (30 of 185 patients) in the non-type O group (p = 0.532). Further bleeding within 30 days occurred in 34 cases (12.6%) in the type O group, and in 26 cases (6.9%) in the non-type O group (p = 0.539). Conclusions: There was no significant difference in blood transfusion volume in 24 h, recurrent bleeding rates, or mortality between patients with blood type O and those with non-type O.

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Post-analytical Issues in Hemostasis and Thrombosis Testing

Favaloro¹,

Lippi²

2017

Methods in Molecular Biology

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Analytical concerns within hemostasis and thrombosis testing are continuously decreasing. This is essentially attributable to modern instrumentation, improvements in test performance and reliability, as well as the application of appropriate internal quality control and external quality assurance measures. Pre-analytical issues are also being dealt with in some newer instrumentation, which are able to detect hemolysis, icteria and lipemia, and, in some cases, other issues related to sample collection such as tube under-filling. Post-analytical issues are generally related to appropriate reporting and interpretation of test results, and these are the focus of the current overview, which provides a brief description of these events, as well as guidance for their prevention or minimization. In particular, we propose several strategies for improved post-analytical reporting of hemostasis assays and advise that this may provide the final opportunity to prevent serious clinical errors in diagnosis.

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Influence of the ABO Blood Type on the Platelet Function Analyzer PFA-100

Cited by 33 publications

References 2 publications

Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study

Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study

Association of ABO Blood Type with Bleeding Severity in Patients with Acute Gastroesophageal Variceal Bleeding

Post-analytical Issues in Hemostasis and Thrombosis Testing

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