Influence of Tetracyclines and Pyridonecarboxylic Acids on Cultured Human Gingival Keratinocytes.

Kojima, Ken; Tanaka, Yuriko; Matsudo, Yuko; Tsutsui, Takeki

doi:10.2329/perio.38.465

Cited by 2 publications

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“…The difference between the cytocidal effects of minocycline and tetracycline on NDUSD-1 cells may be due to mechanisms similar to those observed in normal gingival epithelial cells. When normal human gingival epithelial cells are exposed to the fluoroquinolones enoxacin or ofloxacin, the cytocidal effect is enoxacin > ofloxacin (27), but the mechanism of the cytocidal effects of the fluoroquinolones is not yet known. Fluoroquinolones are well absorbed after oral administration and are widely distributed in body tissues.…”

Section: Discussionmentioning

confidence: 99%

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Effects of eight antibacterial agents on cell survival and expression of epithelial‐cell‐ or cell‐adhesion‐related genes in human gingival epithelial cells

Inoue

Kumakura

Uchida

et al. 2003

J of Periodontal Research

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These results suggest that little, if any, adverse effects on growth, differentiation, and adhesion of basal epithelial cells would be expected with topical administration of clarithromycin, ofloxacin or azithromycin to the periodontal pocket at a dose equivalent to the MIC90. It is important to note, however, that the extrapolation of these findings to in vivo conditions has yet to be undertaken.

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Section: Discussionmentioning

confidence: 99%

“…When normal human gingival epithelial cells are exposed to the fluoroquinolones enoxacin or ofloxacin, the cytocidal effect is enoxacin > ofloxacin (27), but the mechanism of the cytocidal effects of the fluoroquinolones is not yet known. Fluoroquinolones are well absorbed after oral administration and are widely distributed in body tissues.…”

Section: Discussionmentioning

confidence: 99%

Effects of eight antibacterial agents on cell survival and expression of epithelial‐cell‐ or cell‐adhesion‐related genes in human gingival epithelial cells

Inoue

Kumakura

Uchida

et al. 2003

J of Periodontal Research

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Quantitative comparison of cytocidal effects of tetracyclines and fluoroquinolones on human periodontal ligament fibroblasts

Omori

Kobayashi

Tsutsui

1999

J of Periodontal Research

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The cytocidal effects of tetracyclines and fluoroquinolones on human periodontal ligament fibroblasts (Pel cells) were studied. Pel cells were treated for 24 h with tetracycline (TC), demeclocycline (DMC), minocycline (MINO), chlortetracycline (CTC), tosufloxacin (TFLX), enoxacin (ENX), sparfloxacin (SPFX), lomefloxacin (LFLX) or ofloxacin (OFLX), and allowed to form colonies. The cytocidal effects of the antibacterial agents, as determined by a decrease in colony-forming efficiency, increased as the dose increased. However, CTC was an exception. As a quantitative measure of the cytocidal effect, LD50, the concentration which results in a 50% decrease in colony-forming efficiency relative to control cells, was extrapolated from the dose-response curves. The rank-order of cytocidal effects (LD50) was DMC [symbol: see text] MINO [symbol: see text] TC >> CTC. DMC, MINO and TC were at least 5.6-6.6 times more cytocidal than CTC. The cytocidal effects of the fluoroquinolones were in the following order: TFLX > ENX > SPFX > LFLX > OFLX. TFLX, ENX, SPFX and LFLX were 36.3, 11.4, 7.7 and 3.1 times more cytocidal than OFLX, respectively. Little cytocidal effect was observed when the cells were treated with either < or = 0.03 mM tetracyclines or < or = 0.01 mM fluoroquinolones. The results provide useful estimates concerning the relative toxicities against human periodontal ligament of antibacterial agents used to treat periodontitis.

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Influence of Tetracyclines and Pyridonecarboxylic Acids on Cultured Human Gingival Keratinocytes.

Cited by 2 publications

References 0 publications

Effects of eight antibacterial agents on cell survival and expression of epithelial‐cell‐ or cell‐adhesion‐related genes in human gingival epithelial cells

Effects of eight antibacterial agents on cell survival and expression of epithelial‐cell‐ or cell‐adhesion‐related genes in human gingival epithelial cells

Quantitative comparison of cytocidal effects of tetracyclines and fluoroquinolones on human periodontal ligament fibroblasts

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