Influence of testosterone administration at the end of the breeding season on sperm cryoresistance in rams (Ovis aries) and bucks (Capra hircus)

Flores-Gil, V.N.; Blanca, María Gemma Millán de la; Velázquez, Rosario; Toledano-Dı́az, A.; Santiago-Moreno, J.

doi:10.1016/j.domaniend.2019.106425

Cited by 11 publications

(12 citation statements)

References 29 publications

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“…The sperm heads increased in size after the TP treatment, coinciding with that reported for domestic bucks. 18 These findings suggest that higher concentrations of testosterone lead to a larger head size. Certainly, a close relationship exists between blood plasma testosterone and the dimensions of human sperm heads.…”

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confidence: 94%

“…15 In addition, the concept of "good and bad freezers" postulated by Watson might extend beyond variations in the semen of different individuals 16 to the endocrine status of the individual at the moment of semen collection, which may affect the ability of spermatozoa to survive cryopreservation. 17 In most small ruminant species, the circulating testosterone concentration varies seasonally, affecting spermatogenesis and the functionality of sperm cells 18 and accessory glands. 19 High levels of testosterone during the rutting season appear to exert a harmful effect on the cryoresistance of ibex (Capra pyrenaica), 20 mouflon (Ovis musimon), and ram (Ovis aries) 17 spermatozoa.…”

Section: Introductionmentioning

confidence: 99%

“…29 In rams, the administration of TP improves many sperm kinetic variables in fresh samples. 18 In any case, the overall effect of both CA and TP may vary according to the concentration administered.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, many viruses, such as mumps virus, HIV and HSV, 7,14 have been found to impair semen quality, and they may directly interact with spermatozoa or affect spermatogenesis by inducing local inflammation. [15][16][17] Previous studies found that SARS, 1 of the 3 epidemic coronaviruses to emerge in the past 20 years and that shows similar clinical presentations to COVID-19, 18 could cause orchitis 19 and focal testicular atrophy. 20 Considering the tens of millions of COVID-19 cases and that men are more vulnerable to COVID-19 than women, [21][22][23] it is imperative to determine the effect of COVID-19 on male reproduction.…”

Section: Introductionmentioning

confidence: 99%

“…This apparent lack of an association in the changes in blood and seminal plasma agrees with that reported for TP-treated domestic bucks. 18 Indeed, it has been previously reported that the seminal plasma testosterone concentration need not correlate with the blood plasma concentration. 58 It may be that testosterone is locally metabolized into other androgens, such as dihydrotestosterone and androstenedione, 59,60 with a more direct in situ action.…”

mentioning

confidence: 99%

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Influence of circulating testosterone concentration on sperm cryoresistance: The ibex as an experimental model

Bóveda¹,

Esteso²,

Velázquez³

et al. 2021

Andrology

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Background: Recent studies have noted that the circulating testosterone concentration may affect the ability of spermatozoa to survive cryopreservation. However, few attempts to confirm such a relationship have been made. Wild ruminant species have very marked seasonal changes in their reproductive function and strong annual changes in their plasma testosterone concentration. Objectives:The present work examines the influence of induced changes in testosterone secretion on sperm variables following conventional slow freezing and ultrarapid freezing, using the Iberian ibex as an experimental model. Materials and Methods:In a first experiment, testosterone levels were reduced in the middle of the rutting season (December) using the antiandrogen cyproterone acetate (CA). In a second experiment, testosterone levels were increased at the end of the rutting season (January) via the use of the androgen testosterone propionate (TP).Results: During December, the testosterone concentration was found to be higher in the blood and seminal plasma of untreated males than in those of CA-treated males (p < 0.001 and p < 0.05, respectively). Compared with controls, the TP-treated animals had higher blood plasma testosterone concentrations but lower seminal plasma testosterone concentrations during January (p < 0.01 and p < 0.001, respectively).The seminal vesicles of the TP-treated males were larger than those of untreated males (p < 0.05). When CA was administered, sperm viability improved compared with controls (p < 0.05), irrespective of the freezing protocol followed. For the ultrarapid freezing procedure, the cryoresistance ratio for motility decreased when TP was administered (p < 0.05). The values for fresh sperm morphometric variables decreased during the 50 days after the end of CA treatment (p < 0.001) and increased over the same time after the end of TP treatment (p < 0.001). Discussion and Conclusion:The circulating testosterone concentration appears to influence sperm cryoresistance. This may explain the seasonal changes seen in sperm freezability in some species, independent of fresh sperm quality.

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confidence: 94%