Complex block-flexure slope toppling is observed in interbedded sandstone and slate in the upper Yellow River, China. Block toppling is observed in the relatively hard sandstone and flexural toppling is observed in the relatively soft slate. The evolution of toppling slope deformation is characterized by long-term progress and spatial variability. In order to study these characteristics, field investigations, adit prospecting, borehole drilling, sonic tests and numerical simulation were carried out. In addition, the effect of the structure, the composite mode of the rock mass, the unloading fissures and geomorphology are discussed. Furthermore, we explored the toppling mechanisms and simulated it numerically; on this basis, the slope evolution is divided into four stages. Results obtained from the numerical simulation compared well with field investigation data (investigation data, rock sonic survey and strata dip statistics). Comparative studies have demonstrated that the analytical methods presented in this paper are appropriate for back analysis of the toppling evolution process. The result showed that this toppling slope has not yet entered the later progressivity failure stage and is currently limited to collapse at shallow levels, whereas the deep-seated rock mass will remain stable for a long time. This study might provide reference for a stability evaluation and hazard prevention analysis for rock toppling.