Influence of Temperature on Ultraviolet Injury

Freeman, Robert G.

doi:10.1001/archderm.1964.01590300086023

Cited by 69 publications

(21 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bain and colleagues have shown that white ABC mice concurrently exposed to UV plus heat developed high numbers of cutaneous tumours, which manifested after a short period of time, compared to mice exposed to UV radiation at room temperature (25°) or colder (3-5°C). Freeman et al (1964) similarly showed significant increases in tumour development in white mice irradiated with UV at high temperatures. These biological studies suggest that exposure to heat and UV may increase the risk of skin cancer formation.…”

Section: Skin Cancer Pathogenesis and Heat Stressmentioning

confidence: 84%

“…Nevertheless, previous studies have shown that exposure to heat stress, for 1 hour at 38-40°C, prior to UVB irradiation, protects keratinocytes against UVB-induced DNA damage (Kane and Maytin, 1995;Maytin et al, 1994;Trautinger et al, 1995). However, concomitant exposure to UV and heat in mice lead to increased skin cancer incidence (Bain et al, 1943b;Freeman and Knox, 1964). Since Exposure to UVB and heat stress is often experienced either synchronously and/or consecutively in the environment, it is more crucial to determine the effects of repeated and concomitant exposure to UVB radiation plus heat stress on human keratinocytes biology and whether the order of exposures present a significantly different outcome.…”

Section: General Discussion Chapter 5: Heat Stress and Skin Carcinogementioning

confidence: 99%

“…Previous studies on mice have shown that concomitant exposure to UV and heat stress increases the formation of skin lesions (Bain et al, 1943b;Freeman and Knox, 1964;van der Leun et al, 2008). Furthermore, previous studies have shown that heat stress increases SIRT1 protein activity (Raynes et al, 2013a;Westerheide et al, 2009).…”

Section: Theoretical Frameworkmentioning

confidence: 96%

“…Of note, previous studies in mouse models have shown that simultaneous exposure to UV and high temperature increases the incidence and rate of cutaneous tumour formation in mice (Bain et al, 1943b;Freeman and Knox, 1964;van der Leun et al, 2008). Bain and colleagues have shown that white ABC mice concurrently exposed to UV plus heat developed high numbers of cutaneous tumours, which manifested after a short period of time, compared to mice exposed to UV radiation at room temperature (25°) or colder (3-5°C).…”

Section: Skin Cancer Pathogenesis and Heat Stressmentioning

confidence: 96%

See 3 more Smart Citations

Heat stress: A risk factor for skin carcinogenesis

2013

View full text Add to dashboard Cite

Section: Skin Cancer Pathogenesis and Heat Stressmentioning

confidence: 84%

Section: General Discussion Chapter 5: Heat Stress and Skin Carcinogementioning

confidence: 99%

Section: Theoretical Frameworkmentioning

confidence: 96%

Section: Skin Cancer Pathogenesis and Heat Stressmentioning

confidence: 96%

See 2 more Smart Citations

Heat stress: A risk factor for skin carcinogenesis

2013

View full text Add to dashboard Cite

“…It has been surmised on the basis of animal experiments that UV carcinogenesis is a cumulative process, initiated and then augmented by successive doses (Blum, 1976). Heat, humidity and wind enhance this UV-induced tumour formation (Freeman & Knox, 1964;Owens et al, 1974Owens et al, , 1975 and these are factors likely to be present in environments such as coastal beaches where people are often sunburned. Also the damage of UV-B radiation to DNA is well-established, with one of the salient effects being the production of pyrimidine dimers (Epstein, 1983) causing distortion of the double helix.…”

Section: Discussionmentioning

confidence: 99%

Sunburn and malignant melanoma

Green¹,

Siskind²,

Bain³

et al. 1985

Br J Cancer

137

View full text Add to dashboard Cite

Summary We investigated the relationship between cutaneous malignant melanoma and multiple sunburns in the Queensland population. Interview data were gathered from 236 case-control pairs concerning their lifetime experience of severe sunburns, their occupational and recreational sun exposure, and their skin type. Excluding the lentigo maligna melanoma subtype, an association between multiple sunburns and melanoma was evident. After controlling for other major risk factors there was a significant dose-response relationship (P < 0.05): the estimated relative risk associated with 2-5 sunburns in life was 1.5, and with 6 or more was 2.4. This observation extends the hitherto circumstantial evidence of a causal relationship between exposure to solar ultraviolet radiation and melanoma, and suggests that precautionary measures could prevent the development of this disease in a proportion of cases in fair-skinned populations.In spite of the widely held view that exposure to sunlight is related to melanoma, there is a lack of direct supporting evidence (Editorial, Lancet 1981). This may be related in part to problems in quantifying the harmful solar radiation that penetrates the epidermis during sun exposure. There are no established criteria for measuring harmful sun exposure at the target-cell (melanocyte) level on which to base comparisons between populations or individuals. Ideally such criteria would allow quantitation of actual ultraviolet (UV) dose, as the specific carcinogenic wavelengths in sunlight are thought to lie in the UV range (Setlow, 1974), and especially in the UV-B band (280-320 nm) (Granstein & Sober, 1982 In a case-control study in Queensland, Australia, we have examined the relation of UV exposure to cutaneous melanoma by comparing the sunburn experiences accumulated over a lifetime in incident cases, with those of the general population. Materials and methods SubjectsCases were residents of Queensland, who were reported as having a first primary cutaneous melanoma between 1 July, 1979 and 30 June, 1980. The histological diagnoses were provided by pathology laboratories throughout the state. From the year's total of 871 cases, 243 eligible cases were selected at random, 236 (97%) of whom were successfully contacted and interviewed. Controls were randomly selected from the total population by means of electoral rolls (enrolment is compulsory). They were matched to individual cases by age within 5 years, sex and place of residence. The 236 controls represented 92% of the eligible persons contacted (a further 13 were not at the address listed and could not be contacted). ProtocolAll subjects were interviewed by one of us (A.G.) using a standard questionnaire. Respondents were asked to recall all episodes of severe sunburn where pain had persisted longer than 48 h, with or without blistering. The number of sunburn experiences (to a maximum of 9) was recorded for the age groups 0-9, 10-19, 20-29 years, and 30 years and over. Virtually all burns reported occurred before age 40 (there were only 8 sunburns...

show abstract

Parents' use of sunscreen on beach-going children. The burnt child dreads the fire

Maducdoc¹

1992

Archives of Dermatology

View full text Add to dashboard Cite

Influence of Temperature on Ultraviolet Injury

Cited by 69 publications

References 15 publications

Heat stress: A risk factor for skin carcinogenesis

Heat stress: A risk factor for skin carcinogenesis

Sunburn and malignant melanoma

Parents' use of sunscreen on beach-going children. The burnt child dreads the fire

Contact Info

Product

Resources

About