Influence of Tamsulosin on the Anterior Segment Parameters and Central Corneal Thickness

Abstract

To in ves ti ga te the ef fects of tam su lo sin (α-1 ad re ner gic re cep tor an ta go nist) on the ma in nu me ri cal pa ra me ters of an te ri or seg ment using Pen ta cam ro ta ting Sche immp flug came ra, and on bi o mec ha ni cal pa ra me ters using Re ic hert Ocu lar Res pon se Analy ser (ORA) in pa tients with be nign pros ta te hyperp la si a. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : In ad di ti on to full eye exa mi na ti on [best cor rec ted vi su al acu ity, ke ra to metry, in tra o cu lar pres su re (IOP) me a su red with Gold mann app la na ti on to no metry], Pen ta cam [cen tral cor ne al thick ness (CCT), an te ri or cham ber depth, ante ri or cham ber vo lu me, an te ri or cham ber ang le, pu pil di a me ter] and ORA (cor ne al hyste re sis, corne al re sis tan ce fac tor, cor ne al com pen sa ted IOP, Gold mann cor re la ted IOP) me a su re ments of 30 eyes of 15 ma le pa ti ents we re per for med be fo re and one month af ter tam su lo sin the rapy. Pa i red ttest and non-pa ra met ric Wil co xon test we re used for com pa ri sons. R Re e s su ul lt ts s: : Me an age in the study gro up was 61.50±6.10 (ran ge 47-69) ye ars. Af ter tam su lo sin tre at ment, CCT in cre a sed and this incre ment was sta tis ti cally sig ni fi cant (p=0.002). No ne of the ot her pa ra me ters that we re eva lu a ted sho wed sta tis ti cally sig ni fi cant dif fe ren ce af ter tam su lo sin use. C Co on nc c l lu u s si i o on n: : Tam su lo sin le ads to signi fi cant in cre ment in CCT. The ef fects of tam su lo sin on CCT sho uld be ta ken in to con si de ra ti on for pro per cli ni cal in ter pre ta ti on in pa ti ents using tam su lo sin.K Ke ey y W Wo or rd ds s: : Anterior eye segment; corneal topography; tamsulosin Ö ÖZ ZE ET T A Am ma aç ç: : Tam su lo si nin (α1 ad re ner jik re sep tör an ta go nis ti) be nign pros tat hi perp la zi li ol gular da Pen ta cam Sche immp flug ka me ra sis te mi ile çe ki len ön seg ment nü me rik pa ra met re le ri ne ve Re ic hert Ocu lar Res pon se Analy ser (ORA) ci ha zı ile kor ne a nın bi o me ka nik pa ra met re le ri üze ri ne olan et ki le ri nin de ğer len di ril me si. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Top lam 15 er kek ol gu nun 30 gö zü ne tamsu lo sin te da vi si ön ce si ve son ra sı tam of tal mo lo jik mu a ye ne (en iyi dü zel til miş gör me kes kin li ği, kera to met ri, Gold mann ap la nas yon to no met ri si ile öl çül müş gö zi çi ba sın cı (GİB), Pen ta cam [san tral kor ne a ka lın lı ğı (SKK), ön ka ma ra de rin li ği, ön ka ma ra hac mi, ön ka ma ra açı sı, pu pil ça pı] ve ORA (kor ne al his te re zis, kor ne al di renç fak tö rü, kor ne al dü zel til miş GİB, Gold mann dü zel til miş GİB) öl çüm le ri ya pıl dı. Kar şı laş tır ma lar için eş leş ti ril miş t-tes ti ve non-pa ra met rik Wil co xon test le ri kulla nıl dı. B Bu ul l g gu u l la ar r: : Ça lış ma gru bu nun or ta la ma ya şı 61,50±6,10 (47 ve 69 ara sın da) idi. SKK tam su losin te da vi si son ra sın da ön ce si ne gö re ar tış gös te...

Effect of Tamsulosin on Corneal Biomechanical Features

“…A recent study by Storr-Paulsen et al showed that endothelial cell loss after cataract surgery in patients with IFIS are more pronounced. 3 CCT increment in these patients group after tamsulosin therapy with no history of any surgical procedure was also demonstrated by Palamar et al 5 These data support that not only iris and pupillae but also corneal tissue might also be involved by tamsulosin use.…”

“…Palamar et al recently reported the increment on CCT after 1 month of tamsulosin use. 5 ORA is a new non-contact tonometer developed by Reichert, that measures IOP and new metrics, CH and CRF. It uses a metered collimated air pulse to applanate the cornea and an infrared electro-optical system to record inward and outward applanation events.…”

“…7 As changes on CCT are demonstrated to occur after tamsulosin use 5 , we wondered if corneal biomechanics could also be affected by this medication. To our knowledge, no study to date has evaluated the effects of tamsulosin on the corneal biomechanics.…”

Comments To: Anterior Segment Morphologic Changes Related to α-1 Adrenergic Receptor Antagonists Use

“…Several studies reported that patients taking tamsulosin had not only a sluggish iris, but also a small pupil diameter, both making cataract surgery more challenging (2, 3). In 2012, we evaluated changes in anterior segment parameters as measured with the Pentacam rotating Scheimpflug camera (anterior chamber depth, anterior chamber volume, anterior chamber angle width, and pupillary diameter) and corneal biomechanical parameters with the Reichert ocular response analyzer (ORA) (corneal hysteresis, corneal resistance factor) in patients with benign prostate hyperplasia after tamsulosin intake (4). We found that central corneal thickness significantly increased after 1 month of tamsulosin use.…”

Authors’ Reply to Comments To: Anterior Segment Morphologic Changes Related to α-1 Adrenergic Receptor Antagonists Use

“…We found decreased anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) width, and pupil diameter (PD) values in the tamsulosin and doxazosin groups when compared to controls. Palamar et al (2) evaluated patients 1 month after tamsulosin treatment. They did not find any changes in ACD, ACV, ACA width, or PD.…”