Influence of synthetic peptide corresponding to the ACTH-like sequence of human immunoglobulin G1 on activity of murine thymocytes and peritoneal macrophages

Navolotskaya, E. V.; Zargarova, T. A.; Lepikhova, T. N.; Nurieva, Rosa I; Липкин, В. М.; Zav’yalov, Vladimir P.

doi:10.1016/s0165-2478(00)00179-6

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…At the same time, the immunocortin could inhibit proliferation of Con A stimulated LN lymphocytes, which proves the immunosuppressive effects of the peptide on MBP(63–81), and Con A stimulated LN lymphocytes have rather a common grounds. Our results partly support in vitro findings published earlier (Navolotskaya et al, 2000 ), when the immunocortin was shown in vitro to act immunosuppressive on mouse thymocytes, and also by reducing the bactericide activity, and spontaneous motility of peritoneal macrophages. Both thymocytes, and macrophages were shown to have high affinity receptor for ACTH-like peptide, and characteristics of specific binding kinetic for ACTH-like peptide, and 125 I-labeled ACTH(13–24) peptide (ACTH “address segment”) were established.…”

Section: Discussionsupporting

confidence: 93%

“…We studied dose-dependent effect of the peptide MBP(63–81) on proliferation of LN lymphocytes from EAE rats. MBP was purified as described previously (Navolotskaya et al, 2000 ), and used in experiments as a positive control. Both compounds effectively induce LN lymphocyte proliferation and MBP was more active in stimulating LN lymphocytes due to the presence on MBP of more than one antigenic determinant (Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis

et al. 2018

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Peptide immunocortin sequence corresponds to the amino acid residues 11–20 of the variable part of human immunoglobulin G1 (IgG1) heavy chain. Since immunocortin was shown previously to inhibit phagocytosis in peritoneal macrophages and ConA-induced T-lymphocytes proliferation in culture, we suggested that immunocortin administering may be of use for patients with self-immune syndrome. Immunocortin in concentration 10 μM inhibited proliferation of both antigen (myelin)-induced and ConA-induced LN lymphocytes isolated from the lymph nodes of Dark Agouti (DA) rats immunized with chorda shear. The biological trials of the synthetic immunocortin were carried out on the DA rats with induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. These in vivo experiments have shown that intraperitoneal injections of immunocortin in a daily dosage 100 μg per animal reduced symptoms of EAE in DA rats.

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Section: Discussionsupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis

et al. 2018

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Impact of neonatal imprinting with vitamin A or D on the hormone content of rat immune cells

Csaba

Kovács

Pállinger

2006

Cell Biochemistry & Function

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Neonatal single vitamin A (retinol; 3 mg) or vitamin D3 (cholecalciferol; 0.05 mg) treatment (imprinting) was done in male and female rats and 2 months later the endorphin, triiodothyronine (T3) and ACTH content of immune cells (peritoneal lymphocytes, monocyte-granulocyte-macrophage group [mo-gran], mast cells and thymic lymphocytes) were studied immunocytochemically by using flow cytometry and confocal microscopy. The T3 content was significantly decreased in peritoneal lymphocytes and in mo-gran and the endorphin content decreased in thymocytes of male animals, while ACTH was decreased in female lymphocytes and mo-gran. Vitamin D treatment was absolutely ineffective. The imprinting effects of vitamins A and D and their differences are discussed. The results call attention to the possible harmful effect of vitamin treatments during the perinatal critical period.

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Synthetic peptide immunocortin stimulates the production of 11-oxycorticosteroides by rat adrenal cortex through ACTH receptors

Navolotskaya¹,

Vanina²,

Zolotarev³

et al. 2004

Regulatory Peptides

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Influence of synthetic peptide corresponding to the ACTH-like sequence of human immunoglobulin G1 on activity of murine thymocytes and peritoneal macrophages

Cited by 4 publications

References 23 publications

Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis

Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis

Impact of neonatal imprinting with vitamin A or D on the hormone content of rat immune cells

Synthetic peptide immunocortin stimulates the production of 11-oxycorticosteroides by rat adrenal cortex through ACTH receptors

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