Influence of Surgical Procedures on Serum Paraoxonase-1-Related Variables and Markers of Inflammation in Hospitalized Patients

Iftimie, Simona; Escribano, A.; Díez-Sans, Ariadna; Albiciuc, Isabela; Hernández-Aguilera, Anna; Fort-Gallifa, Isabel; López‐Azcona, Ana F.; Camps, Jordi; Joven, Jorge; Castro, Antoni

doi:10.1080/08941939.2019.1597223

Cited by 12 publications

(12 citation statements)

References 32 publications

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“…In addition, as SAA increased during this time frame, both ApoA-1 and PON1 levels decreased [26]. The latest findings by Iftimie et al, who studied the effects of surgery on PON1 and markers of inflammation in hospitalized patients, also show lower PON1 and higher inflammatory markers (monocyte chemoattractant protein 1, CRP and procalcitonin) compared to controls, and the decrease in serum PON1 activity was maintained 14 days post-surgery [27]. Furthermore, several studies support the hypothesis that serum PON1 is decreased in states of increased inflammation and oxidative stress [28,29], and PON1 and HDL-C have shown to be inversely related to CAD [29].…”

Section: Discussionmentioning

confidence: 99%

“…These include the role of other enzymes, such as MPO, or the suppression of PON1 synthesis. The type of surgical procedure and anesthesia may also play a role in PON1 activity, as shown by Iftimie et al [27], and patients on cholesterol lowering medications and other comorbidities such as diabetes may also have altered levels of PON1 [33]. Future studies should address these limitations to better assess how states of acute inflammation can affects PON1 in a larger population.…”

Section: Discussionmentioning

confidence: 99%

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Paraoxonase 1, HDL Subclasses and Post Surgery Acute Inflammation: A Pilot Study

et al. 2019

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High density lipoproteins (HDL) structure and function studies are needed to better understand the heterogeneous nature of the HDL particle, and its interaction with associated proteins such as apolipoprotein A-1 (ApoA-1), paraoxonase 1 (PON1) and the environment. Our study assesses the effects of acute inflammation on PON1 and HDL subclasses in post-surgical colorectal cancer patients. PON1 was measured kinetically through its arylesterase and lactonase activity and HDL sub-classes were measured using Quantimetrix Lipoprint® System. White blood cells (WBC) counts, c-reactive protein (CRP) and serum amyloid A (SAA) levels were also analyzed using standard techniques. Our findings show that baseline PON1 activity is lower in colorectal cancer patients and significant reductions are observed in the acute inflammatory state post-surgery. PON1 changes are also inversely related to inflammatory markers such as SAA and CRP. In addition, our preliminary findings show that small and intermediate HDL decreases post-op Day 1. In conclusion, our study demonstrates the effects of chronic and acute inflammation on PON1. Specifically, PON1 arylesterase and lactonase activity is lower in states of chronic inflammation and further decreased in the acute inflammatory state. Additionally, in our limited sample size, while changes in PON1 and HDL subclasses may be variable in the acute inflammatory period, small HDL decreased with a loss of PON1 activity in the subacute phase.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Paraoxonase 1, HDL Subclasses and Post Surgery Acute Inflammation: A Pilot Study

et al. 2019

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“…Its association in the blood with high-density lipoproteins (HDLs) results in an atheroprotective effect, mainly due to the fact of its ability to prevent low-density lipoprotein (LDL) oxidation. This enzyme has the ability to hydrolyze various types of substrates thus having the complex role of defending against an increase in oxidative stress [7][8][9]. Recently, it was stated that PON1 is linked to a reduction in oxidative stress and inflammation, and it has already been clearly linked to several diseases that express high levels of inflammation such as diabetes mellitus [10].…”

Section: Introductionmentioning

confidence: 99%

Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease

Milaciu

Vesa

Bocşan

et al. 2019

JCM

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Background: Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver diseases around the world. Paraoxonase-1 (PON1) is an enzyme produced by the liver with an important antioxidant role. The aim of this study was to evaluate PON1 serum concentration and PON1 gene polymorphisms in patients with NAFLD. Materials and methods: We studied a group of 81 patients with NAFLD with persistently elevated aminotransferases and a control group of 81 patients without liver diseases. We collected clinical information and performed routine blood tests. We also measured the serum concentration of PON1 and evaluated the PON1 gene polymorphisms L55M, Q192R, and C-108T. Results: There was a significant difference (p < 0.001) in serum PON1 concentrations among the two groups. The heterozygous and the mutated homozygous variants (LM + MM) of the L55M polymorphism were more frequent in the NAFLD group (p < 0.001). These genotypes were found in a multivariate binary logistic regression to be independently linked to NAFLD (Odds ratio = 3.4; p = 0.04). In a multivariate linear regression model, the presence of NAFLD was associated with low PON1 concentration (p < 0.001). Conclusions: PON1 serum concentrations were diminished in patients with NAFLD, and the presence of NAFLD was linked with low PON1 concentration. The LM + MM genotypes of the PON1 L55M polymorphism were an independent predictor for NAFLD with persistently elevated aminotransferases. Author Contributions: Conceptualization, M.V.M., L.C., I.C.B. and M.A.; methodology, M.V.M., L.C., M.A., and S , .C.V.; validation, M.A., L.C., D.M.M., V.N., D.S. and S.P.; formal analysis, S , .C.V.; investigation, M.V.M., L.C., R.M.P., I.C.B. and S.P.; resources, I.C.B., S , .C.V., R.M.P., D.M.M., A.D.B. and A.L.R.; writing-original draft preparation, M.V.M.; writing-review and editing, S , .C.V., L.C., I.C.B. and M.A.; visualization, A.L.R.; supervision,

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“…The number of studies focusing on the course of changes in PON1 concentrations before, during, and shortly after the revascularization procedure or other surgical intervention is limited. Those studies in most cases are based on a small group of patients, and activity was analyzed more often than the concentration of PON1 [29][30][31][32]. Wysocka et al observed a significant increase in the PON1 activity in a group of patients undergoing coronary artery bypass grafting (CABG) [30].…”

Section: Discussionmentioning

confidence: 99%

Changes in the Nrf2/Keap1 Ratio and PON1 Concentration in Plasma of Patients Undergoing the Left Main Coronary Artery Stenting

Kasprzak

Olasińska-Wiśniewska

Gryszczyńska

et al. 2020

Oxidative Medicine and Cellular Longevity

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Nuclear factor erythroid 2-related factor2 (Nrf2), together with its inhibitor Kelch-like ECH-associated protein 1 (Keap1), is a crucial regulator of cellular redox response. Nrf2 binds to the antioxidant response element (ARE) present in the DNA sequence of a broad group of antioxidant compounds, including paraoxonase (PON1), inducing their transcription. This study was to answer the question of the effect of temporary ischemia/oxidative stress resulting from the left main stenting via percutaneous coronary intervention (LMPCI) performed in the patients included in this study on the cellular redox balance, which is guarded by the Nrf2/Keap1 interaction. We expected a reflection of the redox imbalance due to reactive oxygen species (ROS) in the change in PON1 concentration observed in the following stages of the study, as well as in total antioxidant capacity (TAC) levels. Our results showed the mobilization of cellular Nrf2/Keap1 team right after the procedure (pre-LMPCI median: 2.532, range: 0.07-11.88; post-LMPCI median: 3.735, range: 0.1545-16.18; 24 h-LMPCI median: 5.596, range: 0.02-49.18), which suggest being the result of oxidative stress that accompanies percutaneous coronary intervention (PCI). The course of Keap1 and Nrf2 concentrations at all stages of the experiment appeared to show that Keap1 shadowed the Nrf2 to switch off its activity after Nrf2 induced the mobilization of the antioxidant response. We observed an increase in PON1 concentration (pre-LMPCI median: 179.3, range: 49.76-6120; post-LMPCI median: 215.7, range: 3.80-2771) and a decrease in the TAC level immediately after PCI (pre-LMPC: 1.008 ± 0.27 I , post-LMPCI: 0.8030 ± 0.27 ). This study design allowed for the first time to analyze the chronology of mechanisms and the relationship between selected parameters reflecting the redox state in patients’ plasma. We may conclude that ischemia induced by the PCI was the source of imbalance in the Nrf2/Keap1 ratio via oxidative stress, and this leads to an increase in PON1 concentration first and, in the next step, the TAC mobilization.

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Influence of Surgical Procedures on Serum Paraoxonase-1-Related Variables and Markers of Inflammation in Hospitalized Patients

Cited by 12 publications

References 32 publications

Paraoxonase 1, HDL Subclasses and Post Surgery Acute Inflammation: A Pilot Study

Paraoxonase 1, HDL Subclasses and Post Surgery Acute Inflammation: A Pilot Study

Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease

Changes in the Nrf2/Keap1 Ratio and PON1 Concentration in Plasma of Patients Undergoing the Left Main Coronary Artery Stenting

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