Influence of surgical evacuation on pregnancy outcomes of subsequent embryo transfer cycle following miscarriage in an initial IVF cycle: a retrospective cohort study

Meng, Junan; Zhu, Mengchen; Shen, Wenjuan; Huang, Xiaomin; Sun, Haixiang; Zhou, Jianjun

doi:10.1186/s12884-019-2543-9

Cited by 5 publications

(4 citation statements)

References 39 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ozgur et al suggested that women who underwent surgical management for CPL may require 6 months for endometrial functional recovery to optimize the chance of achieving a live birth after FET. A previous study reported that there was no notable difference in pregnancy outcomes of subsequent embryo transfer for women who underwent surgical evacuation compared with those who did not . Surgical evacuation may lead to endometrial damage because of potential complications such as infection and intrauterine adhesion, and thus may play a causal role in endometrial thinning that is closely associated with unfavorable pregnancy outcomes .…”

Section: Discussionmentioning

confidence: 99%

“…A previous study reported that there was no notable difference in pregnancy outcomes of subsequent embryo transfer for women who underwent surgical evacuation compared with those who did not. 29 Surgical evacuation may lead to endometrial damage because of potential complications such as infection and intrauterine adhesion, and thus may play a causal role in endometrial thinning that is closely associated with unfavorable pregnancy outcomes. 30 , 31 In our study, women with an IPI of 6 to 12 months were more likely to undergo surgical evacuation of the preceding CPL and were more likely to have an endometrial thickness of less than 8 mm before FET compared with those with shorter IPIs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Interpregnancy Interval After Clinical Pregnancy Loss and Outcomes of the Next Frozen Embryo Transfer

Wang,

Meng,

Shang

et al. 2023

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceThe optimal interpregnancy interval (IPI) after a clinical pregnancy loss (CPL) remains controversial. Few studies have addressed the role of the IPI after a preceding CPL during in vitro fertilization (IVF) treatment.ObjectiveTo evaluate the association between different IPI lengths after a preceding CPL and pregnancy outcomes of the next frozen embryo transfer (FET).Design, Setting, and ParticipantsThis retrospective cohort study was conducted using data from the Center for Reproductive Medicine of Shandong University in China. The study included women who underwent frozen-thawed blastocyst transfer between July 1, 2017, and June 30, 2022, within 1 year after a preceding CPL during IVF treatment. Follow-up for pregnancy outcomes was completed for all participants on March 31, 2023. Data analysis was performed from April to May 2023.ExposuresInterpregnancy interval length was classified as less than 3 months, 3 to less than 6 months, or 6 to 12 months.Main Outcomes and MeasuresOutcomes included live birth, conception, clinical pregnancy, pregnancy loss, preterm birth, small or large for gestational age, and low birth weight. Multivariable logistic regression analysis was conducted to evaluate the association between IPI and pregnancy outcomes by adjusted odds ratios (AORs).ResultsThis study included 2433 women (mean [SD] age, 31.8 [4.6] years) who received IVF treatment. There were 338 women (13.9%) with an IPI of less than 3 months, 1347 (55.4%) with an IPI of 3 to less than 6 months, and 748 (30.7%) with an IPI of 6 to 12 months. The median (IQR) IPI lengths for the 3 groups were 77 (65-85), 128 (109-152), and 234 (202-288) days, respectively. Compared with an IPI of 6 to 12 months, shorter IPIs (&lt;3 and 3 to &lt;6 months) were associated with decreased odds of clinical pregnancy (AOR, 0.70 [95% CI, 0.53-0.92] and 0.79 [0.65-0.95]), live birth (AOR, 0.64 [95% CI, 0.48-0.85] and 0.74 [0.61-0.90]), and healthy live birth (AOR, 0.63 [95% CI, 0.46-0.87] and 0.79 [0.64-0.98]). Compared with women with an IPI of 6 to 12 months, women with shorter IPIs (&lt;3 and 3 to &lt;6 months) had a higher risk of total pregnancy loss (AOR, 1.87 [95% CI, 1.31-2.67] and 1.29 [1.00-1.66], respectively).Conclusions and RelevanceThe results of this study suggest that delaying the next FET for at least 6 months after a preceding CPL was associated with beneficial pregnancy outcomes, considering that a decreased likelihood of achieving clinical pregnancy and live birth was observed among women with shorter IPIs. Further prospective studies are needed to confirm these findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interpregnancy Interval After Clinical Pregnancy Loss and Outcomes of the Next Frozen Embryo Transfer

Wang,

Meng,

Shang

et al. 2023

JAMA Netw Open

View full text Add to dashboard Cite

show abstract

“…Some embryos were cultured to the blastocyst stage. Blastocyst formation was determined by progression to the blastocyst stage on days 5, 6 or 7 [ 16 ]. For patients who opted to use preimplantation genetic testing for aneuploidy (PGT-A), the embryos were biopsied at the blastocyst stage.…”

Section: Methodsmentioning

confidence: 99%

Association between gestational trophoblastic disease (GTD) history and clinical outcomes in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles

Cai

Zhang

Huang

et al. 2022

Reprod Biol Endocrinol

Self Cite

View full text Add to dashboard Cite

Background Gestational trophoblastic disease (GTD) usually affects young women of childbearing age. After treatment for GTD, 86% of women wish to achieve pregnancy. On account of the impacts of GTD and treatments as well as patient anxiety, large numbers of couples turn to assisted reproductive technology (ART), especially in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). But few studies have investigated whether a history of GTD affects the outcomes of IVF/ICSI in secondary infertile patients and how it occurs. We investigate whether a history of GTD affects the IVF/ICSI outcomes and the live birth rates in women with secondary infertility. Methods This retrospective cohort study enrolled 176 women with secondary infertility who underwent IVF/ICSI treatment at the reproductive medical center of Nanjing Drum Tower Hospital from January 1, 2016, to December 31, 2020. Participants were divided into the GTD group (44 women with GTD history) and control group (132 women without GTD history matched from 8318 secondary infertile women). The control group and the study group were matched at a ratio of 3:1 according to patient age, infertility duration, number of cycles and body mass index (BMI). We assessed retrieved oocytes and high-grade embryos, biochemical pregnancy, miscarriage, ectopic pregnancy, gestational age at delivery, delivery mode and live birth rates. Result(s) We found a significantly reduced live-birth rate (34.1% vs 66.7%) associated with IVF/ICSI cycles in patients with a GTD history compared to those without a GTD history. The biochemical pregnancy and miscarriage rates of the GTD group were slightly higher than those of the control group. In addition, there was a difference in gestational age at delivery between the GTD and control groups (p < 0.001) but no differences in the mode of delivery (p = 0.267). Furthermore, the number of abandoned embryos in the GTD group was greater than that in the control group (p = 0.018), and the number of good-quality embryos was less than that in the control group (p = 0.019). The endometrial thickness was thinner (p < 0.001) in the GTD group. Immunohistochemistry (IHC) showed abnormal endometrial receptivity in the GTD group. Conclusion(s) The GTD history of patients undergoing IVF/ICSI cycles had an impact on the live-birth rate and gestational age at delivery, which might result from the thinner endometrium and abnormal endometrial receptivity before embryo transfer.

show abstract

“…Recurrent miscarriage (RM) refers to cases where three or more recurrent miscarriages occur before the twentieth week of pregnancy [ 1 ]. According to the World Health Organization (WHO), RM refers to the expulsion or death of a fetus weighing less or more than 500 grams within the 20 th to 24 th week of pregnancy [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The Investigation of Metabonomic Pathways of Serum of Iranian Women with Recurrent Miscarriage Using 1H NMR

Latifimehr

Zamani

Esfahani

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Purpose. Recurrent miscarriage applies to pregnancy loss expulsion of the fetus within the first 24 weeks of pregnancy. This study is aimed at comparatively investigating the sera of women with RM with those who have no record of miscarriages to identify if there were any metabolite and metabolic pathway differences using 1H NMR spectroscopy. Methods. Serum samples were collected from women with RM ( n = 30 ) and those who had no records of RM ( n = 30 ) to obtain metabolomics information. 1H NMR spectroscopy was carried out on the samples using Carr Purcell Meiboom Gill spin echo; also, Partial Least Squares Discriminant Analysis was performed in MATLAB software using the ProMetab program to obtain the classifying chemical shifts; the metabolites were identified by using the Human Metabolome Database (HMDB) in both the experimental and control groups. The pathway analysis option of the Metaboanalyst.ca website was used to identify the changed metabolic pathways. Results. The results of the study revealed that 14 metabolites were different in the patients with RM. Moreover, the pathway analysis showed that taurine and hypotaurine metabolism along with phenylalanine, tyrosine, and tryptophan biosynthesis was significantly different in patients with RM. Conclusion. The present study proposes that any alteration in the above metabolic pathways might lead to metabolic dysfunctions which may result in a higher probability of RM.

show abstract

Influence of surgical evacuation on pregnancy outcomes of subsequent embryo transfer cycle following miscarriage in an initial IVF cycle: a retrospective cohort study

Cited by 5 publications

References 39 publications

Interpregnancy Interval After Clinical Pregnancy Loss and Outcomes of the Next Frozen Embryo Transfer

Interpregnancy Interval After Clinical Pregnancy Loss and Outcomes of the Next Frozen Embryo Transfer

Association between gestational trophoblastic disease (GTD) history and clinical outcomes in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles

The Investigation of Metabonomic Pathways of Serum of Iranian Women with Recurrent Miscarriage Using 1H NMR

Contact Info

Product

Resources

About