Influence of Surgery on the Pharmacokinetics of Tramadol Following Intravenous Administration in Dogs

Buhari, S; Goh, Yong Meng; Gan, Siew Hua

doi:10.3923/ajava.2013.483.492

Cited by 2 publications

(3 citation statements)

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“…To the authors' knowledge, published clinical PK studies have evaluated only the effect of surgery on the disposition of analgesics such as meloxicam (Karademir et al 2016) and tramadol (Buhari et al 2013) in dogs. In those studies, a decreased V ss and decreased Cl were found together with increased AUC values, compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

“…In those studies, a decreased V ss and decreased Cl were found together with increased AUC values, compared to the control group. These changes were associated with major haemodynamic changes during surgery, as blood volume may be altered because of blood loss or venous pooling (Buhari et al 2013;Karademir et al 2016), but also a decreased CO and peripherical tissue perfusion, owing to vasodilation caused by anaesthesia, could have an important effect (Kennedy and Van Rij 1998;Owens et al 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have evaluated the PK parameters of IV analgesic drugs in anaesthetized animals during surgery, including ketorolac in dogs (Cagnardi et al 2013) and tramadol in horses (Cagnardi et al 2014), but no control groups were used. Recently, studies using a control group have been published, but these focused on evaluating the effect of surgery on the plasma disposition of meloxicam and tramadol following IV administration in dogs (Buhari et al 2013;Karademir et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Influence of general anaesthesia on the intravenous acetaminophen pharmacokinetics in Beagle dogs

Granados

Mengual

Navarrete‐Calvo

et al. 2021

Veterinary Anaesthesia and Analgesia

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Objective To determine if general anaesthesia influences the intravenous (IV) pharmacokinetics (PK) of acetaminophen in dogs.Study design Prospective, crossover, randomized experimental study.Animals A group of nine healthy Beagle dogs.Methods Acetaminophen PK were determined in conscious and anaesthetized dogs on two separate occasions. Blood samples were collected before, and at 5, 10, 15, 30, 45, 60 and 90 minutes and 2, 3, 4, 6, 8, 12 and 24 hours after 20 mg kg e1 IV acetaminophen administration. Haematocrit, total proteins, albumin, alanine aminotransferase, aspartate aminotransferase, urea and creatinine were determined at baseline and 24 hours after acetaminophen. The anaesthetized group underwent general anaesthesia (90 minutes) for dental cleaning. After the administration of dexmedetomidine (3 mg kg e1 ) intramuscularly, anaesthesia was induced with propofol (2e3 mg kg e1 ) IV, followed by acetaminophen administration. Anaesthesia was maintained with isoflurane in 50% oxygen (FE 0 Iso 1.3e1.5%). Dogs were mechanically ventilated. Plasma concentrations were analysed with high-performance liquid chromatography. PK analysis was undertaken using compartmental modelling. A Wilcoxon test was used to compare PK data between groups, and clinical laboratory values between groups, and before versus 24 hours after acetaminophen administration. Data are presented as median and range (p < 0.05).Results A two-compartmental model best described timeeconcentration profiles of acetaminophen. No significant differences were found for volume of distribution values 1.41 (0.94e3.65) and 1.72 (0.89e2.60) L kg e1 , clearance values 1.52 (0.71e2.30) and 1.60 (0.91e1.78) L kg e1 hour e1 or terminal elimination half-life values 2. 45(1.45e8.71) and 3.57 (1.96e6.35) hours between conscious and anaesthetized dogs, respectively. Clinical laboratory variables were within normal range. No adverse effects were recorded.Conclusions and clinical relevance IV acetaminophen PK in healthy Beagle dogs were unaffected by general anaesthesia under the study conditions. Further studies are necessary to evaluate the PK in different clinical contexts.

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Section: Discussionmentioning

confidence: 99%