Influence of strontium on structure, sintering and biodegradation behaviour of CaO–MgO–SrO–SiO2–P2O5–CaF2 glasses

Effect of strontium inclusion on the bioactivity of phosphate-based glasses

“…Thestrontium-containing bioglass have shown that the effect of strontium inclusion on the atomic structure is rather small, even for quite large (B25%) concentrations of SrO [15]. However, the inclusion of Sr decreases bioactivity by decreasing the apatite-forming ability and dissolution rate [12] of bioglass.…”

Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study

“…17,18 It has also been demonstrated that bioactive glass and glass-ceramics that include local strontium show biocompatibility. [19][20][21][22] The positive effects of strontium on peri-implant bone formation have led researchers to develop various methods of local strontium administration. These methods include strontium-substituted hydroxyapatite implants, modification of metal oxide layers with a strontium-containing salt, generation of strontium titanate nanotubes on the surfaces of metal implants, bioactive glass comprising strontium, and incorporation of strontium into metal oxide layers on implant surfaces.…”

The key Features expected from a Perfect Bioactive Glass –How Far we still are from an Ideal Composition?

“…In a sub-series of compositions, MgO was partially replaced (1-10 mol %) by ZnO [30], while in another sub-series CaO was partially replaced (1-10 mol %) by SrO [31]. In a third sub-series of compositions, these partial oxide substitutions were combined in an equimolar basis [32,33].…”

“…The pH values of the suspensions are lower in comparison to those of 45S5 Bioglass® and the particle size of powder frits can be more conveniently reduced and expose a larger surface area to the dispersion liquid without undergoing a so extensive dissolution [37,38]. Still more important from the overall processing point of view is the excellent sintering ability, achieving full densification before the onset of crystallization, resulting in strong mechanical properties [25][26][27][28][31][32][33]. Figure 4 compares porous scaffolds fabricated by robo casting, an extrusion based additive manufacturing technique that enables designing not only the external form and dimensions, but also tailoring the internal structure.…”

“…In a third sub-series of compositions, these partial oxide substitutions were combined in an equimolar basis [32,33]. The effects of such individual or combined substitutions on the relevant properties of the resulting bioactive glasses were investigated and reported in several publications [30][31][32][33].These alkali-free bioactive glasses revealed to have several distinctive features including: moderate degradation rate, accompanied by a fast bio mineralisation rate in vitro with the formation of a hydroxycarbonate apatite (HCA) surface layer after 1 h of immersion in simulated body fluid (SBF) [26,30,32]; the ability to reduce oxidative stress [30,32]; osteogenic activity, inducing the differentiation of hMSCs into bone forming cells even in the absence of osteogenic medium [29]. This osteo induction effect was significantly greater in comparison to that of 45S5 Bioglass® [34]; and excellent bone bonding ability confirmed by in vivo studies using sheep as animal model [35].…”