Influence of Some Factors on Development of Experimental Cholesterol Atherosclerosis

Myasnikov, A. A.

doi:10.1161/01.cir.17.1.99

Cited by 146 publications

(22 citation statements)

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“…Alth ough there are few empirical and epidemiologic studies supporting the hypothesis on the CO-atherosclerosis rel ation ship, it has been show n that the devel opment of atheros cleros is and coronary lipid deposition can be enhanced by arterial hypoxia (37,38). Tissue oxy gen insufficiency cau sed by long-lasting exposure to CO could be one patho geni c factor in the development of atheromatosis.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular diseases among foundry workers exposed to carbon monoxide.

Koskela¹

1994

Scand J Work Environ Health

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1KOSKELA R-S. Cardiovascular diseases among foundry workers exposed to carbon monoxide. Scand J Work Environ Health 1994;20:286-93. OBJECTIVES -The study investigated long-term effects of carbon monoxide (CO) exposure on foundry workers' morbidity and mortality from cardiovascular diseases. METHODS -The study population comprised a cohort of 2857 men hired in 1950-1972 by 20 Finnish foundries and also 931 men who were still active in 1972, exposed for at least 4.2 years, took part in a health examination in 1973; 653 of the 931 had also been members of the cohort. These groups were followed to the end of 1987. RESULTS -The age-standardized incidence density rate (1011000 person-years) for compensated medication for hypertension was 4.7 for the unexposed workers and 9.4 for those exposed [rate ratio (RR) 2.0, 95% confidence interval (95% CI) 1.28-2.92]; for the iron foundry workers the rates were 4.7 and 9.9 (RR 2.1, 95% CI 1.24-3.38), respectively. During 1950-1987,255 cardiovascular deaths were observed (284 expected according to nationalrates). The observednumber of deaths due to ischemic heart disease was 183 (203 expected). The iron foundry workers' mortality rate for cardiovascular deaths was 99% of the national expected value. No remarkable differences were found between the CO-exposure categories. For the health-examination group, the age-standardized incidence rate for compensated medication for hypertension was 9.1 for the unexposed nonsmokers and 21.4 for the exposed smokers (RR 2.3, 95% CI 0.97-6.35); the difference originated among the iron foundry workers, for whom the rates were 8.1 and 24.0 (RR 3.0, 95% CI 0.96-9.78), respectively. The age-standardized mortality rate (IDIIOOO person-years) was 2.7 for nonsmokers with no or slight CO exposure and 9.2 for exposed smokers (95% CI 1.13-12.11). This difference was mainly caused by ischemic heart disease. CONCLUSIONS -The results indicate that CO exposure increases the risk of cardiovascular morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular diseases among foundry workers exposed to carbon monoxide.

Koskela¹

1994

Scand J Work Environ Health

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“…O mesmo autor, Myasnikow (45), fez interessantes observações sobre a ação de várias substâncias no desenvolvimento da aterosclerose experim ental. Restringirem o--nos, apenas, à ação das substâncias neurotrópicas: fenobarbital (Luminal) e fenam ina (Benzedrina), de efeitos opostos.…”

Section: Parasitismo E Doença Parasitáriaunclassified

O fenômeno parasitismo

Ferreira¹

1973

Rev. Soc. Bras. Med. Trop.

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Luiz F e rn a n d o F e rre ira ** "A t ali leveis of organization, the outcome of the interplay between two individuais is ãe-term ined not only by their intrinsic endowments but also and even more, by the conditions under which they come into contact". René Dubos "Infectious disease is the result of much more than the mere collision of an infectious agent w ith a potencial host". H . J . Simon I -O ENFOQUE ECOLÓGICO O ser vivo como meio ambienteOs autores modernos têm procurado de finir o fenômeno parasitism o em termos ecológicos, o organismo de um ser vivo sendo um h ab itat, que pode ser utilizado por outro ser vivo. O processo em suas linhas gerais é sem elhante ao que ocorre na adaptação ao meio físico. Dentro dessa linha, Levine ((40) define a parasitologia como: " . . . b ra n d i of ecology in which one organism is the environm ent for ano ther" . A mesma idéia vamos encontrar em Noble e Noble (49): " . . . one m ight consider the parasit in an organ of the host as a ccm m unity. . . the latter being the externai environm ent of the community" ou em Huff e col. (32): "one area oí ecology deals with systems of biotic relations, systems in which one organism lives on or in another in order to obtain sustenance" .No trabalho de Barreto (4) encontra mos: "O corpo de um ser vivo, digamos de um anim al superior, para maior faci lidade de compreensão, oferece nichos po tenciais p ara outros organismos. Eles in vadem aquele, quer à procura de alim en to, quer em busca de abrigo, quer para obter am bas as coisas" .O enfoque ecológico no estudo do p a rasitismo tem m estrado um a enorme ri queza de conseqüências. No seu processo de evolução, os seres vivos se têm adap tado às mais diferentes condições do meio am biente. Assim, como foi possível a pas sagem da vida aquática para terrestre, da mesma m aneira que o homem se tem * T ra b a lh o do L ab o rató rio de P a ra sito lo g ia do I n s t it u t o P re sid e n te C astello B ranco -F u n d a ç ã o I n s ti t u t o O sw aldo C ruz. ** P ro fesso r T itu la r d e P arasito lo g ia.R ecebido p a ra p u b lic a ç ã o em 24.4.1973. Condições como a tem peratura, por exemplo, da mesma m aneira que afeta a distribuição das espécies de vida livre, também interfere em relação às espécies parasitas. A parasitem ia em Rana catesbeiana infectada por Trypanosoma rotatorium é profundam ente influenciada pela tem peratura. Observações antigas, já 'haviam m ostrado a sua im portância na resistência da galinha e da rã, ao tétano e ao carbúnculo. Barrow (5) cham a a atenção para a influência da tem peratura na infecção da salam andra pelo Trypa nosoma diemyctili.Assim como em am bientes em que há carência de alim ento as populações vão apresentar determ inadas alterações, o mes mo vai acontecer com os anim ais p arasitos. K nauft e W arren (35) estudaram o efeito do déficit proteico e calórico no p a rasito e no hospedeiro, em camundongos infectados com S. mansoni. Nas dietas deficitárias, observaram diminuição nas posturas do verme, e assinalam que as grandes deficiências ca...

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“…Vitamin C has been reported to prevent subsequent hypercholesterolaemia in animals fed a high-cholesterol diet (Sokoloff et af. 1966;Bavina 1958;Myasnikov 1958). But there are few reports on the effect of vitamin C administration on normal blood cholesterol levels.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin C Administration on Serum and Egg-yolk Cholesterol Level of the Chicken

Al-Janabi¹,

AI-Kattib²,

Taha³

1988

Aust. Jnl. Of Bio. Sci.

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Ascorbic acid (vitamin C) was given to 144-days-old layer chickens mixed with their ration at three concentrations: 30, 60 and 90 p.p.m. for 6 months. Cholesterol levels in blood serum (CS) and egg yolk (CE) were measured every 6 weeks (four periods); there was a marked decrease in CS in most treated birds, especially those receiving the highest concentration of vitamin C. There was also a slight decrease in CE in most treated birds. Thyroidal weight showed a significant increase in most treated groups, especially those receiving the highest concentration of vitamin C.

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Influence of Some Factors on Development of Experimental Cholesterol Atherosclerosis

Cited by 146 publications

References 0 publications

Cardiovascular diseases among foundry workers exposed to carbon monoxide.

Cardiovascular diseases among foundry workers exposed to carbon monoxide.

O fenômeno parasitismo

Effect of Vitamin C Administration on Serum and Egg-yolk Cholesterol Level of the Chicken

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