Influence of Solvent Selection in the Electrospraying Process of Polycaprolactone

Abstract

Electrosprayed polycaprolactone (PCL) microparticles are widely used in medical tissueengineering, drug control release delivery, and food packaging due to their prominent structuresand properties. In electrospraying, the selection of a suitable solvent system as the carrier of PCL isfundamental and a prerequisite for the stabilization of electrospraying, and the control ofmorphology and structure of electrosprayed particles. The latter is not only critical for diversifyingthe characteristics of electrosprayed particles and achieving improvement in their properties, butalso promotes the efficiency of the process and deepens the applications of electrosprayed particlesin various fields. In order to make it systematic and more accessible, this review mainly concludesthe effects of different solution properties on the operating parameters in electrospraying on theformation of Taylor cone and the final structure as well as the morphology. Meanwhile,correlations between operating parameters and electrospraying stages are summarized as well.Finally, this review provides detailed guidance on the selection of a suitable solvent systemregarding the desired morphology, structure, and applications of PCL particles.

Avaliação morfológica de fibras eletrofiadas de policaprolactona em função do tipo de solvente

“…Esse comportamento pode ser atribuído à alta condutividade da solução, que promove a formação de contas, tornando o processo de eletrofiação similar ao processo conhecido como "electrospray". O comportamento é concordante com o relatado por ZHANG et al (2019) [25], que mostrou a existência de uma relação direta entre a viscosidade, a tensão superficial e a condutividade com a voltagem aplicada, fazendo com que para uma determinada solução, deva existir uma condição na qual estas variáveis permitam a formação estável do cone de Taylor. O resultado é também de acordo com os resultados reportados por ENIS et al (2016) [26], que demostraram que o ácido fórmico (AF), por ser um ácido com alto poder iônico, possui alta condutividade elétrica, fato também verificado pelos valores da Tabela 1, onde é evidenciado que com o aumento da concentração do AF de 10% para 30% em volume, gera um incremento aproximado de 17 vezes na condutividade elétrica para o sistema AC/AF.…”

Electrohydrodynamic Processes and Their Affecting Parameters

“…The presence of the conical surface at the tip of the nozzle during electrospraying is also called Taylor cone. According to Rayleigh's theory, when the charge quantity distributed on the surface of droplets reaches the value between 50 and 80% of the Rayleigh limit, the breakup and fission of charged droplets occur due to Coulomb repulsions among charged droplets [58]. A classical electrospray setup is considered, with the glass capillary tube situated at a distance (d) from a grounded counter-electrode.…”

“…All these parameters directly affect the formation of the Taylor cone, which leads to the production of particles having a low mean diameter and narrow particle size distribution. Therefore, to gain a better understanding of the electrospraying technique and achieve low mean diameter and narrow particle size distribution, it is essential to thoroughly understand the effects of all of these governing parameters [58].…”

Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

“…These processes include padding, bath exhaustion, spraying, and layer-by-layer deposition methods, which are sketched in Figure 3. In most cases, drying and curing steps are performed in order to achieve a better fixation of the carriers onto the textile surface [165,166,167]. According to the final applications, the process aims to control the final amount of drugs loaded on the garments; moreover, the fixation treatment is designed in order to tune the interaction strength between the fabric and the carriers.…”