Influence of solvent effect on polymorphism of 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide-1, 1-dioxide (piroxicam)

Crystallization and disorder of the polytypic α1and α2polymorphs of piroxicam

“…In 1991, Janik et al studied the influence of various solvents on the crystallization behaviour, and reported that the "α structure" crystallized from ethanol, isopropanol, THF, acetonitrile and chloroform. 23 We find some conflicting results: we observe that form I crystallizes as large rods from acetonitrile or chloroform under slow evaporation at 25 °C. However, the conclusions of Janik et al were made solely on the basis of IR spectra, without measurement of PXRD patterns, so the effectiveness of their polymorph identification may be in doubt.…”

Particle Engineering: Fundamentals of Particle Formation and Crystal Growth

“…For instance, the role of solvent can influence the crystallization outcome, as evident in the case of piroxicam, in which the á-form is crystallized from proton donor and basic solvents, whereas the b-form is obtained from nonpolar solvents. 28 It is impossible to guarantee that all solid-state forms of a given compound will be discovered, since there is no method that provides a full exploration of the polymorph landscape. However, high-throughput crystallization screening has been an effective approach to determine new solid forms.…”

Elucidating the Polymorphic Behavior of Curcumin during Antisolvent Crystallization: Insights from Raman Spectroscopy and Molecular Modeling

“…This involves identifying prenucleation clusters such as dimers or catemers in solution by employing in situ spectroscopic techniques. Such clusters have been reported to facilitate the formation of a certain polymorph over another. − Literature shows that the identification of such solute-rich clusters ultimately governs the final polymorphic outcome. − While some researchers reported a direct correlation between the solution chemistry and the polymorphic outcome that was found, others could not find any link between the two. , Understanding the solute–solvent interactions to critically identify the intermolecular interactions governing the formation of such clusters therefore becomes crucial to comprehend the phenomena of nucleation. Molecular dynamics (MD) has been used extensively as a tool to investigate the role of solvents in dictating the nucleation process.…”