Influence of Sodium Hyaluronate Concentration in Tear Meniscus Height: 10-min Dynamic Profile After Single Instillation

Abstract

To assess the height, area, and density of tear meniscus throughout 10 min after instillation of sodium hyaluronate (SH) of equal molecular weight at two different concentrations. Methods: Thirty-four eyes from 17 patients were enrolled in this longitudinal, nonrandomized, interventional and contralateral eye study. Tear meniscus height (TMH), corneal meniscus junction (CMJ), lower-lid meniscus junction (LLMJ), and tear meniscus area (TMA) images were obtained with the anterior segment module of the deep range imaging ocular coherence tomography ([DRI-OCT] Triton Swept-Source). Tear meniscus density (TMD) was calculated using the image processing and analysis software by Java (ImageJ program). Sodium hyaluronate artificial tears at 0.1% and 0.2% concentrations were instilled into all right and left eyes, respectively. Results: Patients' mean age was 61.05611.43 years. Tear meniscus height, CMJ, LLMJ, and TMA measured at 1-, 5-, 7-and 10-min postinstillation of 0.1% SH proved significant differences among them (P,0.05). Sodium hyaluronate 0.2% instillation obtained similar findings, although no significant differences were found between 1-and 3-min postinstillation measurements (P.0.05). Fewer differences were found in TMD 0.2% SH group due to a lower baseline densitometry compared to the 0.1% group. Conclusion: 0.2% sodium hyaluronate achieved better TMH and TMA in 1 and 3 min after instillation than 0.1% concentration. However, there were no statistically significant differences between 0.1% and 0.2% sodium hyaluronate throughout a ten-minute longitudinal profile measurement using DRI-OCT.

Lipid, Aqueous and Mucin Tear Film Layer Stability and Permanence within 0.15% Liposome Crosslinked Hyaluronic Acid versus 0.15% Non-Crosslinked Hyaluronic Acid Measured with a Novel Non-Invasive Ocular Surface Analyzer

“…Our results showed an increase in TMH in both groups, which was slightly higher in the LCHA group. Other authors have come to similar results, all of which indicate an increase in TMH after the use of HA [41][42][43]. The slight difference in the LCHA group may be due to its higher viscosity and therefore longer contact time on the ocular surface that LCHA provides.…”