Influence of sodium bicarbonate on myocardial performance

Clancy, R. L.; Cingolani, H.E.; Taylor, R D; Tp, Graham; Jp, Gilmore

doi:10.1152/ajplegacy.1967.212.4.917

Cited by 99 publications

(19 citation statements)

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“…The choice of NaaCO3 rather than NaHCOa was based upon the fact that smaller volumes of Na2CO3 may be used to alkalinize the dog. In addition, Na2CO3 tends to diminish C02 tensions in blood whereas NaHCOa increases blood C02 tensions and may thereby produce transient "respiratory" acidosis if ventilatory compensation is not complete (31). Small increases in serum osmolality were observed with these infusions (see Results section).…”

Section: Resultsmentioning

confidence: 90%

“…Received for publication 31 July 1974 and in revised form 26 November 1974. has been possible to show that lactate concentrations in coronary sinus blood increase as myocardial perfusion is reduced, the development of cellular acidosis in ischemic mammalian hearts has not been documented. It was the purpose of the present study to determine the effect of coronary occlusion upon myocardial cell pH in the dog.…”

Section: Introductionmentioning

confidence: 99%

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In vivo myocardial cell pH in the dog. Response to ischemia and infusion of alkali.

Effros¹,

Haider²,

Ettinger³

et al. 1975

J. Clin. Invest.

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A B S T R A C T Myocardial cell pH has been measured with 5,5-dimethyl-2,4-oxazolidinedione (DMO) in intact anesthetized dogs by a transient indicator dilution technique. Bolus injections of labeled DMO, vascular, extracellular, and water indicators were made into the anterior descending coronary artery, and blood samples were collected from the great cardiac vein. The steadystate distribution of DMO between cells and plasma was calculated from the indicator mean transit times, and the plasma pH was estimated from arterial and great cardiac vein pH. Myocardial cell pH was determined from the distribution value and plasma pH. Normal myocardial cell pH averaged 6.94. Changes in myocardial cell pH averaged 58% of concomitant changes in plasma pH after infusions of acid or alkali. Myocardial ischemia induced by inflation of a coronary artery balloon resulted in progressive decreases in cellular pH to average values of 6.83 within the initial 15 min and to 6.59 within the interval between 20 and 70 min. Infusions of NaaCOa tended to diminish intracellular acidosis although these infusions had little effect on the difference in pH between the myocardial cell and extracellular fluid. INTRODUCTIONReductions in coronary blood flow are rapidly followed by the production of large amounts of lactic acid by the

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Section: Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

In vivo myocardial cell pH in the dog. Response to ischemia and infusion of alkali.

Effros¹,

Haider²,

Ettinger³

et al. 1975

J. Clin. Invest.

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“…This effect was eliminated after DNP (2mM) which affects the mitochondria. These results indicate that the changes in external pH act mainly on the sarcolemma and a rise of pH produces the positive inotropic effects by enhancing the Ca-influx due to Is as well as Na-Ca exchange mechanism, although the mitochondria tended to show a minor counter action.It has long been demonstrated that, in cardiac muscle, alterations in extracellular pH exhibit marked inotropic effects (VAUGHAN WILLIAMS, 1955;MCELROY et al, 1958; LoRKoVIC, 1966;CLANCY et al, 1967;VAUGHAN WILLIAMS and WHYTE, 1967), and several theories have been proposed to show that the inotropic effects of pH are caused by 1) the changes in extracellular pH (VAUGHAN WIL- …”

mentioning

confidence: 99%

“…It has long been demonstrated that, in cardiac muscle, alterations in extracellular pH exhibit marked inotropic effects (VAUGHAN WILLIAMS, 1955;MCELROY et al, 1958; LoRKoVIC, 1966;CLANCY et al, 1967;VAUGHAN WILLIAMS and WHYTE, 1967), and several theories have been proposed to show that the inotropic effects of pH are caused by 1) the changes in extracellular pH (VAUGHAN WIL-…”

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confidence: 99%

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EFFECTS OF pH ON THE PROCESSES OF EXCITATION-CONTRACTION COUPLING OF BULLFROG ATRIUM

Wada

Goto²

1975

Jpn.J.Physiol

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Effects of external pH on the electrical and mechanical properties were investigated on the bullfrog atrium under voltage-clamped and unclamped conditions with double-gap method in order to elucidate the principal site of pH action. On rising the pH (5.3-8.3) a marked positive inotropic effect and an increase in rate of rise of action potential were produced with a shortening of the plateau duration. The potassium contracture was also augmented.Under voltage-clamped conditions, fast (If) and slow inward currents (Is) as well as delayed outward current were enhanced indicating a definite action of pH on the surface membrane. Is-dependent and independent contractile tensions in response to a small (70mV, 0.2sec) and large depolarizing pulses (200mV, 1.0 sec) were both strengthened. Excess caffeine (20mM) Ringer solution augmented the effects of pH, while Ca-free La (1mM) Ringer solution abolished, suggesting a minor role of the sarcoplasmic reticulum in the pH effects. A contracture in Na-free high Ca (80mM) solution was enhanced by lowering external pH. This effect was eliminated after DNP (2mM) which affects the mitochondria. These results indicate that the changes in external pH act mainly on the sarcolemma and a rise of pH produces the positive inotropic effects by enhancing the Ca-influx due to Is as well as Na-Ca exchange mechanism, although the mitochondria tended to show a minor counter action.It has long been demonstrated that, in cardiac muscle, alterations in extracellular pH exhibit marked inotropic effects (VAUGHAN WILLIAMS, 1955;MCELROY et al., 1958; LoRKoVIC, 1966;CLANCY et al., 1967;VAUGHAN WILLIAMS and WHYTE, 1967), and several theories have been proposed to show that the inotropic effects of pH are caused by 1) the changes in extracellular pH (VAUGHAN WIL-

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Alteration of Oxygen Tension and Oxyhemoglobin Saturation

Douglas¹

1979

Arch Surg

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Influence of sodium bicarbonate on myocardial performance

Cited by 99 publications

References 0 publications

In vivo myocardial cell pH in the dog. Response to ischemia and infusion of alkali.

In vivo myocardial cell pH in the dog. Response to ischemia and infusion of alkali.

EFFECTS OF pH ON THE PROCESSES OF EXCITATION-CONTRACTION COUPLING OF BULLFROG ATRIUM

Alteration of Oxygen Tension and Oxyhemoglobin Saturation

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