Influence of Socioeconomic and Environmental Determinants of Health on Human Infection and Colonization with Antibiotic-Resistant and Antibiotic-Associated Pathogens: A Scoping Review

Forrester, Joseph D.; Cao, Siqi; Schaps, Diego; Liou, Raymond; Patil, Advait; Stave, Christopher D; Sokolow, Susanne H.; Leo, Giulio De

doi:10.1089/sur.2021.348

Cited by 7 publications

(13 citation statements)

References 109 publications

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“…Methicillin-resistant Staphylococcus aureus colonization of the nares has long been associated with SSI and is shown to increase during the summer 49 . Enterobacter aerogenes has been found to grow best in high-temperature high-humidity conditions on a variety of surfaces, likely due to decreased desiccation stress 9 . While increased skin colonization during hot and humid conditions likely contributes to increased SSI incidence, other mechanisms may exist and warrant further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…Patients could have developed SSI before the surveillance window ended, potentially reducing the effect size of weather variables on SSI. Second, Marketscan ® does not include key demographic data such as race and income, which have been shown to be contributors to SSI in certain surgical procedures 9,35 . Populations not represented in this study include the uninsured, those on Medicaid, and those who live outside an MSA.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the heavy burden SSIs place on patients and the healthcare system, much effort has been devoted to identifying SSI risk factors and developing mitigation strategies. However, current research and prevention strategies focus predominantly on perioperative and patient characteristics-the impact of meteorological variables such as temperature, humidity, and precipitation are less well understood [5][6][7][8][9] .…”

mentioning

confidence: 99%

“…As the planet's climate continues to change, burden of these diseases is expected to rise 17 . Yet data describing relationships between SSIs and meteorological variables remains sparse 9 . Studies using single-center and national healthcare datasets have shown a temporal relationship between specific surgical procedures and SSI occurrence, with peak SSI rates occurring during summer months [18][19][20][21][22] .…”

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confidence: 99%

“…Studies using single-center and national healthcare datasets have shown a temporal relationship between specific surgical procedures and SSI occurrence, with peak SSI rates occurring during summer months [18][19][20][21][22] . However, relationships between specific climate conditions such as temperature, humidity, and precipitation and SSI are not well-studied and these studies do not analyze the effect of regional variability on climate-related SSIs 9 .…”

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confidence: 99%

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Effect of climate on surgical site infections and anticipated increases in the United States

Liou

Earley

Forrester

2022

Sci Rep

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Surgical site infections (SSI) are one of the most common and costly hospital-acquired infections in the United States. Meteorological variables such as temperature, humidity, and precipitation may represent a neglected group of risk factors for SSI. Using a national private insurance database, we collected admission and follow-up records for National Healthcare Safety Network-monitored surgical procedures and associated climate conditions from 2007 to 2014. We found that every 10 cm increase of maximum daily precipitation resulted in a 1.09 odds increase in SSI after discharge, while every g/kg unit increase in specific humidity resulted in a 1.03 odds increase in SSI risk after discharge. We identified the Southeast region of the United States at highest risk of climate change-related SSI, with an estimated 3% increase in SSI by 2060 under high emission assumptions. Our results describe the effect of climate on SSI and the potential burden of climate-change related SSI in the United States.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Effect of climate on surgical site infections and anticipated increases in the United States

Liou

Earley

Forrester

2022

Sci Rep

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Animal sources of antimicrobial-resistant bacterial infections in humans: a systematic review

Fastl¹,

Ferreira²,

Martins³

et al. 2023

Epidemiol. Infect.

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Bacterial antimicrobial resistance (AMR) is among the leading global health challenges of the century. Animals and their products are known contributors to the human AMR burden, but the extent of this contribution is not clear. This systematic literature review aimed to identify studies investigating the direct impact of animal sources, defined as livestock, aquaculture, pets, and animal-based food, on human AMR. We searched four scientific databases and identified 31 relevant publications, including 12 risk assessments, 16 source attribution studies, and three other studies. Most studies were published between 2012 and 2022, and most came from Europe and North America, but we also identified five articles from South and South-East Asia. The studies differed in their methodologies, conceptual approaches (bottom-up, top-down, and complex), definitions of the AMR hazard and outcome, the number and type of sources they addressed, and the outcome measures they reported. The most frequently addressed animal source was chicken, followed by cattle and pigs. Most studies investigated bacteria–resistance combinations. Overall, studies on the direct contribution of animal sources of AMR are rare but increasing. More recent publications tailor their methodologies increasingly towards the AMR hazard as a whole, providing grounds for future research to build on.

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Predicting Increased Incidence of Common Antibiotic-Resistant and Antibiotic-Associated Pathogens Using Ensemble Species Distribution Modeling

Brough,

Caddell,

Liou

et al. 2024

The Journal of Infectious Diseases

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The Centers for Disease Control estimates antibiotic-associated pathogens result in 2.8 million infections and 38,000 deaths annually in the United States. This study applies species distribution modeling to elucidate the impact of environmental determinants of human infectious disease in an era of rapid global change. We modeled methicillin-resistant Staphylococcus aureus and Clostridioides difficile using 31 publicly accessible bioclimatic, healthcare, and sociodemographic variables. Ensemble models were created from 8 unique statistical and machine learning algorithms. Using International Classification of Diseases, 10th Edition codes, we identified 305,528 diagnoses of methicillin-resistant S.aureus and 302,001 diagnoses of C.difficile presence. Three environmental factors – average maximum temperature, specific humidity, and agricultural land density – emerged as major predictors of increased methicillin-resistant S.aureus and C.difficile presence; variables representing healthcare availability were less important. Species distribution modeling may be a powerful tool for identifying areas at increased risk for disease presence and have important implications for disease surveillance systems.

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Influence of Socioeconomic and Environmental Determinants of Health on Human Infection and Colonization with Antibiotic-Resistant and Antibiotic-Associated Pathogens: A Scoping Review

Cited by 7 publications

References 109 publications

Effect of climate on surgical site infections and anticipated increases in the United States

Effect of climate on surgical site infections and anticipated increases in the United States

Animal sources of antimicrobial-resistant bacterial infections in humans: a systematic review

Predicting Increased Incidence of Common Antibiotic-Resistant and Antibiotic-Associated Pathogens Using Ensemble Species Distribution Modeling

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