Influence of smoking on the prognostic value of cardiovascular computed tomography coronary angiography

Werkhoven, Jacob M. van; Schuijf, Joanne D.; Pazhenkottil, Aju P.; Herzog, B; Ghadri, Jelena R.; Jukema, J. Wouter; Boersma, Eric; Kroft, Lucia J.M.; Roos, Albert de; Kaufmann, Philipp A.; Bax, Jeroen J.

doi:10.1093/eurheartj/ehq441

Cited by 13 publications

(3 citation statements)

References 46 publications

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“…However, CACS might be limited for predicting CAD progression in heavy smokers without calcium since it is not feasible to depict the degree of stenosis or NCP, which is related to acute coronary syndrome [7,24]. Recently, the correlation between cigarette smoking and significant CAD by MDCT was reported by van Werkhoven et al [20]. In their study, significant CAD was strongly correlated with smoking, which is supported by our results.…”

Section: Discussionsupporting

confidence: 86%

“…A large number of studies that discuss the relationship between cigarette smoking and CAD, according to various imaging techniques have been published; however, in most of the reports, smoking was restricted to current and noncurrent smoking behavior [19,20]. In this regard, we subdivided non-current smokers into never-and ex-smokers, and investigated any differences on the impact on SCA.…”

Section: Discussionmentioning

confidence: 99%

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Coronary CT angiography findings based on smoking status: Do ex-smokers and never-smokers share a low probability of developing coronary atherosclerosis?

Chun

Lee

et al. 2015

Int J Cardiovasc Imaging

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The relationship of coronary artery disease (CAD) in ex-smokers has not been elucidated, although smoking is considered to be one of the major risk factors of CAD. We investigate subclinical coronary atherosclerosis (SCA) in asymptomatic subjects with coronary computed tomography angiography (CCTA), according to smoking status, and determine whether ex-smokers share a low probability of developing CAD with never-smokers. We retrospectively enrolled 6930 self-referred asymptomatic adults who underwent both coronary artery calcium score (CACS) and CCTA. The prevalence and characteristics of SCA were assessed according to smoking status (never-, ex- and current smokers). After adjusting for variable risk factors, we used multivariate logistic regression for adjusted odds ratios (AOR) of high CACS (>100), SCA (any plaque), significant stenosis (>50 % in luminal stenosis) and each plaque type (non-calcified, mixed and calcified plaque) among the three groups. The prevalence of SCA was highest in the ex-smokers (35.4 %) and the prevalence of significant stenosis in ex-smokers (6.9 %) was as high as in current smokers (6.4 %). However, after adjusting for variable risk factors, SCA was significantly correlated with both ex-smokers (AOR; 1.21) and current smokers (AOR; 1.25), whereas significant stenosis was correlated only with current smokers (AOR; 1.91). The association between SCA and ex-smokers is as strong as with current smokers, although significant stenosis is only correlated with current smokers; thus, not only quitting smoking but also never initiating smoking would be helpful to reduce the progression of the SCA.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Coronary CT angiography findings based on smoking status: Do ex-smokers and never-smokers share a low probability of developing coronary atherosclerosis?

Chun

Lee

et al. 2015

Int J Cardiovasc Imaging

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“…Smoking is also linked to cardiovascular diseases [3], stroke [4] and fertility disorders [5]. Moreover, an increased risk of mortality from cardiovascular diseases and cancer has been associated with cigarette smoking and exposure to cigarette smoke [6–8).…”

Section: Introductionmentioning

confidence: 99%

Reduced coenzyme Q10 in female smokers and its association with lipid profile in a young healthy adult population

Al-Bazi¹,

Elshal²,

Khoja³

2011

aoms

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IntroductionCigarette smoking has a negative effect on body reserve of antioxidants and cholesterol metabolism. Coenzyme Q10 (CoQ10), a potent antioxidant synthesized as part of the cholesterol pathway, is a potential biomarker for systemic oxidative stress. We aimed to investigate gender variation in plasma lipid profile and CoQ10 concentrations in healthy non-smokers and in smokers.Material and methodsThe study included 55 cigarette smokers (25 females and 30 males) and 51 non-smokers (25 females and 26 males) with the age range from 21 to 45 years, and who had no history of alcohol abuse or chronic diseases such as diabetes mellitus or obesity. Coenzyme Q10 plasma concentrations were measured by reverse-phase high performance liquid chromatography (HPLC) with ultraviolet detection. Fasting plasma glucose and lipid levels were determined by standard colorimetric methods.ResultsOur results showed that CoQ10 concentrations were significantly decreased in smokers, especially in females, than their non-smoker counterparts. Female smokers also exhibited a significant decrease in plasma concentrations of total cholesterol (TC), HDL-C, LDL-C, and atherogenic ratios HDL-C/TC and CoQ10/LDL-C than male counterparts. Plasma triglyceride concentrations were increased in smokers irrespective of gender. Plasma CoQ10 was relatively more associated with TC and LDL-C in female smokers than male smokers.ConclusionsThe adverse effects of smoking on body reserve of antioxidants and cholesterol metabolism are greater in females than in males, partially as a result of decreased CoQ10 plasma concentrations, HDL-C and total-cholesterol and abnormal atherogenicity indices.

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Association between smoking habits and severity of coronary stenosis as assessed by coronary computed tomography angiography

et al. 2015

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Smoking promotes arteriosclerosis and is one of the most important coronary risk factors. However, few studies have investigated the association between smoking habits and the severity of coronary stenosis as assessed by coronary computed tomography angiography (CTA). We enrolled 416 patients [165/251 = smoker (past and current)/non-smoker)]. They had all undergone CTA and either were clinically suspected of having coronary artery disease (CAD) or had at least one cardiovascular risk factor. We divided the patients into smoking and non-smoking groups, and evaluated the presence of CAD, the number of significantly stenosed coronary vessels (VD), and the Gensini score as assessed by CTA in the two groups. The incidence of CAD, VD, the Gensini score, and coronary calcification score in the smoking group were all significantly greater than those in the non-smoking group (CAD, p = 0.009; VD, p = 0.003; Gensini score, p = 0.007; coronary calcification score, p = 0.01). Pack-year was significantly associated with VD and the Gensini score, and was strongly associated with multi-vessel disease (2- and 3-VD) (p < 0.05), whereas the duration of cessation in past smokers was not associated with VD or the Gensini score. Pack-year, but not the duration of cessation, may be the most important factor that was associated with the severity of coronary stenosis in terms of VD and the Gensini score.

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Influence of smoking on the prognostic value of cardiovascular computed tomography coronary angiography

Cited by 13 publications

References 46 publications

Coronary CT angiography findings based on smoking status: Do ex-smokers and never-smokers share a low probability of developing coronary atherosclerosis?

Coronary CT angiography findings based on smoking status: Do ex-smokers and never-smokers share a low probability of developing coronary atherosclerosis?

Reduced coenzyme Q10 in female smokers and its association with lipid profile in a young healthy adult population

Association between smoking habits and severity of coronary stenosis as assessed by coronary computed tomography angiography

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