Influence of smoking on fertility in women attending an in vitro fertilization program

Sterzik, K.; Strehler, E.; Santo, M. De; Trumpp, N.; Abt, Markus; Rosenbusch, B.; Schneider, Achim

doi:10.1016/s0015-0282(16)58219-3

Cited by 87 publications

(38 citation statements)

References 12 publications

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“…However, the lower peak E2 levels [21,22] and recruitment of fewer follicles and oocytes [7,13,15,21,23,24] in smokers that were reported in earlier studies were not observed in our population, in which milder and less vigorous stimulation was required.…”

Section: Discussioncontrasting

confidence: 78%

Influence of smoking on outcome of COH and IUI in subfertile couples

Farhi

Orvieto

2009

J Assist Reprod Genet

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Aim To evaluate the influence of smoking on the outcome of COH and IUI in subfertile couples. Patients and methods We reviewed the medical files of all consecutive women, age ≤35 years, attending our infertility clinics over an eigth-year period. Data on patient age, smoking habits, and variable related to infertility-treatment were collected from the files. Results A total of 2,318 cases were evaluated: 1,803 in nonsmoking patients (n=679) and 515 in smokers (n=206). The smokers used significantly more gonadotropin ampoules and gained a thinner endometrium on the day of hCG administration than the nonsmokers (p<0.016 for both). There were no between-groups differences in patient age, duration of gonadotropin stimulation, number of follicle >14 mm in diameter, or E2 levels on the day of hCG administration. Conclusion Smokers undergoing COH with IUI required a significantly higher gonadotropin dosage than nonsmokers in order to achieved a comparable pregnancy rate.

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Section: Discussioncontrasting

confidence: 78%

Influence of smoking on outcome of COH and IUI in subfertile couples

Farhi

Orvieto

2009

J Assist Reprod Genet

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“…These effects seem to be reversible, because women who quit smoking before undergoing in vitro fertilization have had the same pregnancy rates as nonsmokers (6). Other investigators have been unable to show adverse effects of smoking on fertilization and pregnancy rates in women with tubal disease who were grouped based on their follicular cotinine (a long-lasting metabolite which serves as a marker of exposure rates) concentration (7). There are several mechanisms by which CS may induce its antifertility effects.…”

mentioning

confidence: 99%

Cigarette smoke inhibits endometrial epithelial cell proliferation through a nitric oxide–mediated pathway

Khorram

Han

Magee

2010

Fertility and Sterility

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“…Celle-ci agirait immédiatement après la reprise de la méiose, entraînant un déficit relatif en ovocytes de maturité intermédiaire [18] au profit des ovocytes de maturité complète. Ce phénomène se traduirait par une augmentation du taux de fertilisation (nombre d'embryons/nombre d'ovocytes) chez les fumeuses [7,23,24]. Des anomalies plus fines des ovocytes ont pu être observées, grâce aux études menées en AMP, comme une augmentation de l'épaisseur de la zone pellucide, que le tabagisme soit actif ou passif.…”

Section: En Assistance Médicale à La Procréationunclassified