Influence of Site, Size, Depth of Invasion and Histologic Grading on the Occurrence of Cervical Level IIb Metastasis and Extranodal Extension in Clinically N0 Neck of Patients with OSCC: A Single Center Retrospective Analysis

Bera, Rathindra Nath; Singh, Akhilesh Kumar; Tripathi, Richik; Sharma, Naresh

doi:10.1007/s12663-022-01776-5

Cited by 2 publications

(2 citation statements)

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“…The incidence of OM is reported to be 7-33.75% in cN0 OSCC [7][8][9][10][11][12]. This study observed OM in 9 (10.5%) of the 86 patients, consistent with previous reports.…”

Section: Discussionsupporting

confidence: 91%

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Predictors of Occult Metastasis and Prognostic Factors in Patients with cN0 Oral Cancer Who Underwent Elective Neck Dissection

Yamagata,

Fukuzawa,

Noguchi

et al. 2024

Diseases

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Elective neck dissection (END) is recommended for the management of patients with oral squamous cell carcinoma (OSCC) because of the risk of occult metastasis (OM). We hypothesized that some factors predict poor prognosis regardless of a cN0 END. This study aimed to investigate the predictors of OM and prognostic factors in patients with cN0 OSCC who underwent supraomohyoid neck dissection (SOHND). A retrospective cohort study design was created and implemented. The primary predictive variables in this study were OM and risk factors for poor prognosis after SOHND. A Cox proportional hazard model was used to adjust for the effects of potential confounders on the risk factors for poor prognoses. Among 86 patients with OSCC, OMs were observed in 9 (10.5%). The neutrophil-to-lymphocyte ratio (NLR) and vascular invasion are good markers for detecting OM. A Cox multivariable analysis identified two independent predictors of overall survival: pathologic node (pN) and laterality of END. An independent predictive factor for disease-free survival, the surgical margin, was also identified in this study. According to the pN classification, pN1 patients had a worse survival rate than pN2 patients. Therefore, in the case of pN1, regardless of being cN0, additional adjuvant therapy may be necessary.

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“…The incidence of OM is reported to be 7-33.75% in cN0 OSCC [7][8][9][10][11][12]. This study observed OM in 9 (10.5%) of the 86 patients, consistent with previous reports.…”

Section: Discussionsupporting

confidence: 91%

“…The incidences of metastases following neck dissection (ND) in cN0 oral squamous cell carcinoma (OSCC) are reportedly 7-33.75%. However, the early resection of LN metastases may increase the chances of survival [7][8][9][10][11][12]. Although failure after SOHND occurs in 2.1% of the cases, SOHND is appropriate for treating cN0 OSCC [8].…”

Section: Introductionmentioning

confidence: 99%