In this study, a Computational Fluid Dynamics (CFD) technique was used to develop a model for the simulation and flow conditions of the incinerator. The CFD technique are based on subdividing the volume of interest, i.e., the combustion chamber (or other parts of the plant) into a grid of elementary volumes. The relevant equations of conservation (mass, momentum, energy) are then applied to each of those elements, after defining all inputs, outputs and boundary conditions. The resulting system is then integrated from start to finish, after introducing momentum, mass and heat transfer. The objective of the study was to evaluate and optimize the performance of locally available incinerators in Tanzania. The small scale municipal solid waste incinerator modelling was done by using a fluent solver. The case study of the existing incinerator at a Bagamoyo hospital in Tanzania was used as a model and the obtained values were compared with simulated results and other publications for validation. The design optimization using CFD techniques to predict the performance of incinerator showed the deviation of input air by 14%, the mass flow rate by 26.5%,