Influence of short‐term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals

Huss‐Marp, Johannes; Eberlein-König, Bernadette; Breuer, Klaus; Mair, Stefan; Ansel, A; Darsow, Ulf; Krämer, Ursula; Mayer, Erick F.; Ring, Johannes; Behrendt, Heidrun

doi:10.1111/j.1365-2222.2006.02448.x

Cited by 92 publications

(71 citation statements)

References 42 publications

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“…A study of skin biopsies from 75 AD patients found an association between AD severity and reactive oxygen species (ROS) associated damage, supporting the hypothesis that ROS generated by environmental exposures cause oxidative damage to proteins in the stratum corneum [149]. Even short-term exposure to NO 2 or VOC caused significantly increased TEWL in both healthy individuals and those with AD [150,151]. VOC may also contribute to Th-2 polarization, suggesting potentially direct effects of pollutants on the immune system [152].…”

Section: Mechanisms Of Pollutants-mentioning

confidence: 84%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

240

225

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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Section: Mechanisms Of Pollutants-mentioning

confidence: 84%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

240

225

View full text Add to dashboard Cite

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“…Scheuplein and Ross (1970) graded the defatting potential of solvents based on water permeation as follows: ethanol < acetone < diethyl ether < chloroform < methanol:chloroform mixture. Although skin-damaging eVect of solvents is usually associated with contact to liquids, exposure to vapours of volatile organic solvents may equally damage the epidermal barrier (Huss-Marp et al 2006;Costa et al 2006). The inXuence of solvents on skin permeability has been studied in several in vivo studies.…”

Section: Organic Solventsmentioning

confidence: 99%

Absorption of chemicals through compromised skin

Kežić

Nielsen

2009

Int Arch Occup Environ Health

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Skin is an important route of entry for many chemicals in the work place. To assess systemic uptake of a chemical in contact with the skin, quantitative information on dermal absorption rates of chemicals is needed. Absorption rates are mainly obtained from studies performed with intact, healthy skin. At the work place, however, a compromised skin barrier, although not necessarily visible is common, e.g. due to physical and chemical damage. As reviewed in this article, there are several lines of evidence that reduced integrity of the skin barrier may increase dermal absorption of chemicals in the occupational setting. An impaired skin barrier might lead not only to enhanced absorption of a specific chemical, but also to entrance of larger molecules such as proteins and nanoparticles which normally are not able to penetrate intact skin. In addition to environmental influences, there is increasing evidence that some individuals have an intrinsically affected skin barrier which will facilitate entrance of chemicals into and through the skin making these persons more susceptible for local as well for systemic toxicity. This review addresses mechanisms of barrier alteration caused by the most common skin-damaging factors in the occupational settings and the consequences for dermal absorption of chemicals. Furthermore, this review emphasizes the importance of maintained barrier properties of the skin.

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“…A defective skin barrier may allow penetration of mite molecules into the lower epidermis and dermis [5,6,7,8,9,10]. Molecules in mite material include both allergens and nonallergens, and some of these are enzymes.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulation of Skin Cytokine Secretion by House Dust Mite Extracts

Arlian

Morgan²

2011

Int Arch Allergy Immunol

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Background: Skin contact with house dust mites may contribute to atopic dermatitis and other skin diseases. We sought to determine if molecules from house dust mites could influence the release of proinflammatory cytokines and chemokines from epidermal keratinocytes and dermal fibroblasts grown in a human skin equivalent (HSE) model. Methods: HSEs consisting of an epidermis of keratinocytes with stratum corneum over a dermis of fibroblasts in a collagen matrix were challenged with Dermatophagoides farinae, D. pteronyssinus and Euroglyphus maynei mite extracts. Results: HSEs secreted interleukin (IL)-1α, IL-1 receptor antagonist, IL-6, IL-8, cutaneous T cell-attracting chemokine, transforming growth factor-α, granulocyte/macrophage and macrophage colony-stimulating factors and vascular endothelial cell growth factor in response to at least 1 mite extract. Extracts of different mite species stimulated HSEs to release different cytokines. Therefore, extracts of different species contained different molecules or different concentrations of similar molecules. The cytokine release profiles of cells in the HSEs were not the same as for monocultured keratinocytes and fibroblasts. Conclusions: Molecules from house dust mites are capable of inducing the release of multiple proinflammatory cytokines and chemokines from epidermal keratinocytes and dermal fibroblasts. Avoiding skin contact with house dust mites would reduce the possibility of mite-induced inflammation in the skin. Therefore, measures to reduce contact with mite molecules such as frequent vacuuming of upholstered furniture and carpets and laundering of clothing and bedding to remove mite molecules and allergens could reduce skin contact with mite molecules and diminish exacerbations of skin inflammation in patients with atopic dermatitis and other skin diseases.

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Influence of short‐term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals

Cited by 92 publications

References 42 publications

Environmental risk factors and their role in the management of atopic dermatitis

Environmental risk factors and their role in the management of atopic dermatitis

Absorption of chemicals through compromised skin

Immunomodulation of Skin Cytokine Secretion by House Dust Mite Extracts

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