Influence of Sex on the Blood Brain Barrier Permeability During Bicuculline-Induced Seizures

Öztaş, Baria; Çamurcu, Safi̇naz; Kaya, Mehmet

doi:10.3109/00207459209003284

Cited by 25 publications

(17 citation statements)

References 22 publications

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“…One of the original findings in this study is, when compared to males, female rats have less destruction in blood-brain barrier permeability both in normothermic and hyperthermic convulsive groups. Whereas studies on adults show that females have a greater breakdown of blood-brain barrier [11]. In rat pups, the difference caused by sex cannot be linked to the sex steroids, as they are not secreted in prepuberty.…”

Section: Discussionmentioning

confidence: 91%

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Gender Difference in the Influence of Antioxidants on the Blood–Brain Barrier Permeability During Pentylenetetrazol-Induced Seizures in Hyperthermic Rat Pups

Öztaş

Akgul

Seker

2007

Biol Trace Elem Res

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Our purpose in this study was to investigate the protective effects of selenium and vitamin E on the blood-brain barrier (BBB) permeability in rats with convulsion under hyperthermic conditions. To eliminate the effect of sex on BBB, we performed our study on 4- to 5-week-old prepubertal rat pups. Evans-blue was used as a BBB tracer. Convulsions were induced by administration of i.p. pentylenetetrazol. In the selenium group, 4 ppm selenium was added to the drinking water for 4-5 weeks. Vitamin E was administered at 700 mg/kg ip. It was shown that the convulsions, both under normothermic and hyperthermic conditions, caused widespread increase in the BBB permeability (p < 0.05). In addition, a significant difference was observed among female and male rats (f [1, 102] = 6.387, p < 0.05). In convulsions under normothermic conditions, there was a further increase in the BBB permeability (F[3, 102] = 43.534, p < 0.001) and a greater increase of permeability in males compared to females (F[1, 102] = 6.387, p < 0.05). Selenium and vitamin E significantly decreased the BBB destruction caused by convulsions under hyperthermic conditions in males (p < 0.05). Treatment with selenium or vitamin E has beneficial effects on the BBB breakdown during convulsions. But gender differences are very important in BBB permeability under pathological conditions and antioxidant treatments.

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Section: Discussionmentioning

confidence: 91%

“…By using 14 Csucrose, Cragg and Philips [10] were the first to report that female rats have increased blood-brain barrier permeability. Oztas et al [11] showed in their study with bicuculline that blood-brain barrier is destroyed differently in different sexes. Convulsions lead to greater breakdown of blood-brain barrier in females.…”

Section: Discussionmentioning

confidence: 97%

Gender Difference in the Influence of Antioxidants on the Blood–Brain Barrier Permeability During Pentylenetetrazol-Induced Seizures in Hyperthermic Rat Pups

Öztaş

Akgul

Seker

2007

Biol Trace Elem Res

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“…Different species have differences in the permeability of the blood-brain barrier to many compounds (Bradbury, 1979), probably related to differences in the densities of nucleoside transporters (reviewed in , that also make it problematic to compare neurogenesis between species. Additionally, treatments that disrupt the blood-brain barrier, e.g., kainate or seizures (Oztas et al, 1992;Pont et al, 1995), or alter the flow of blood to the brain, e.g., exercise (Ide and Secher, 2000), could produce increases in BrdU-labeled cell number independent of changes in proliferation by altering BrdU availability in the brain. It should be possible to avoid these problems if BrdU doses are high enough that all S-phase cells are labeled in all treatment groups.…”

Section: High Doses Of Brdu Are Required To Label All S-phase Cells Imentioning

confidence: 99%

Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus

Cameron

McKay

2001

J of Comparative Neurology

1,405

1,137

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Knowing the rate of addition of new granule cells to the adult dentate gyrus is critical to understanding the function of adult neurogenesis. Despite the large number of studies of neurogenesis in the adult dentate gyrus, basic questions about the magnitude of this phenomenon have never been addressed. The S-phase marker bromodeoxyuridine (BrdU) has been extensively used in recent studies of adult neurogenesis, but it has been carefully tested only in the embryonic brain. Here, we show that a high dose of BrdU (300 mg/kg) is a specific, quantitative, and nontoxic marker of dividing cells in the adult rat dentate gyrus, whereas lower doses label only a fraction of the S-phase cells. By using this high dose of BrdU along with a second S-phase marker, [ 3 H]thymidine, we found that young adult rats have 9,400 dividing cells proliferating with a cell cycle time of 25 hours, which would generate 9,000 new cells each day, or more than 250,000 per month. Within 5-12 days of BrdU injection, a substantial pool of immature granule neurons, 50% of all BrdU-labeled cells in the dentate gyrus, could be identified with neuron-specific antibodies TuJ1 and TUC-4. This number of new granule neurons generated each month is 6% of the total size of the granule cell population and 30 -60% of the size of the afferent and efferent populations (West et al. [1991] Anat Rec 231:482-497; Mulders et al. [1997] J Comp Neurol 385:83-94). The large number of the adult-generated granule cells supports the idea that these new neurons play an important role in hippocampal function.

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“…Cragg and Phillips [21] were the first to report that the blood-brain barrier of females shows greater permeability. Oztas et al [15] have also shown that the blood-brain barrier breakdown has differences between genders during bicucullin-induced seizures.…”

Section: Discussionmentioning

confidence: 93%

“…Because gender is an important factor on the blood-brain barrier permeability in different pathological conditions [15] and brain glucose utilisation [16], we decided to compare the effects of hypoglycemia and lifelong sodium selenite administration on the blood-brain barrier permeability of male and female experimental animals under chemically induced convulsion.…”

Section: Introductionmentioning

confidence: 99%

Lifelong Consumption of Sodium Selenite: Gender Differences on Blood–Brain Barrier Permeability in Convulsive, Hypoglycemic Rats

Seker

Akgul

Öztaş

2008

Biol Trace Elem Res

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The aim of this study was to compare the effects of hypoglycemia and induced convulsions on the blood-brain barrier permeability in rats with or without lifelong administration of sodium selenite. There is a significant decrease of the blood-brain barrier permeability in three brain regions of convulsive, hypoglycemic male rats treated with sodium selenite when compared to sex-matched untreated rats (p<0.05), but the decrease was not significant in female rats (p>0.05). The blood-brain barrier permeability of the left and right hemispheres of untreated, moderately hypoglycemic convulsive rats of both genders was better than their untreated counterparts (p<0.05). Our results suggest that moderate hypoglycemia and lifelong treatment with sodium selenite have a protective effect against blood-brain barrier permeability during convulsions and that the effects of sodium selenite are gender-dependent.

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Influence of Sex on the Blood Brain Barrier Permeability During Bicuculline-Induced Seizures

Cited by 25 publications

References 22 publications

Gender Difference in the Influence of Antioxidants on the Blood–Brain Barrier Permeability During Pentylenetetrazol-Induced Seizures in Hyperthermic Rat Pups

Gender Difference in the Influence of Antioxidants on the Blood–Brain Barrier Permeability During Pentylenetetrazol-Induced Seizures in Hyperthermic Rat Pups

Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus

Lifelong Consumption of Sodium Selenite: Gender Differences on Blood–Brain Barrier Permeability in Convulsive, Hypoglycemic Rats

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