Influence of sex on cytokines, heat shock protein and oxidative stress markers in response to an acute total body resistance exercise protocol

Benini, Ricardo; Nunes, Paulo Ricardo Prado; Orsatti, Cláudio Lera; Portari, Guilherme Vannucchi; Orsatti, Fábio Lera

doi:10.1016/j.jesf.2014.10.002

Cited by 23 publications

(23 citation statements)

References 33 publications

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“…These results are consistent with those published by R. Benini et al. who showed that men expressed significantly higher levels of IL6 after a strength training session [ 32 ]. Overall, evidence about differences in the immune responses between sexes has been found.…”

Section: Discussionsupporting

confidence: 93%

Differential inflammatory response of men and women subjected to an acute resistance exercise

et al. 2021

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Background The purpose of this study was to investigate the inflammatory response, lipid peroxidation and muscle damage in men and women athletes subjected to an acute resistance exercise. Methods Twenty college athletes (10 men and 10 women) performed a half-squat exercise consisting of five incremental intensities: 20%, 40%, 60%, 80% and 100% of the one-repetition maximum. Blood samples were collected at rest, 15 min and 24 h post-test. The concentration of lipid peroxidation markers and the activities of a skeletal muscle damage marker and a cardiac muscle damage marker were determined in serum. Serum α-actin was measured as a marker of sarcomere damage. Serum levels of interleukin-6, interleukin-10, and tumor necrosis factor alpha were determined to assess the inflammatory response. Results Interleukin-6 levels were higher at 24 h post-test than at rest and 15 min post-test in men ( p < 0.05). Moreover, men showed significantly higher hydroperoxide levels in response to resistance exercise at 24 h post-test than at 15 min post-test ( p < 0.05). No differences were found in muscle damage parameters regardless of sex or the time point of the test. No differences regarding the studied variables were found when comparing among different time points in women. Conclusion Our results show a larger influence of half-squat exercises on the release of IL6 and on lipid peroxidation in men than in women at equivalent workloads.

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Section: Discussionsupporting

confidence: 93%

Differential inflammatory response of men and women subjected to an acute resistance exercise

et al. 2021

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“…Any influence of sex on changes in HSP70 levels was observed in horses under study, in agreement with what is reported in humans, in response to a single bout of total body resistance exercise (Benini et al, 2015).…”

Section: Discussionsupporting

confidence: 90%

Serum Heat Shock Protein (HSP70) Changes In Horses After An Acute Exercise

2021

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Heat shock proteins (HSP) play critical roles in the body’s self-defense under a variety of stresses. In particular, HSP70 is a key regulator of normal physiological processes including physical exercise. Exercise is associated with transient increases of HSP expression in rodents, humans and horses, but so far little is presently known about the effects of acute high-intensity exercise or training on the release of HSP70 in the blood of horses. The aim of the study was to investigate the effect of acute exercise as racehorse intensive training and gallop race on serum HSP70 levels. The research was carried out on 12 trained horses performing regularly training and gallop race. Serum HSP70 levels were analyzed by ELISA assay before and immediately after the end of both training and gallop race sessions. Results showed significant increased levels of serum HSP70, both after the end of the whole training session and gallop race, compared to basal values. A physiological stress associated with acute physical exercise seems to activate HSP70 pathway also in horses, suggesting the presence of an adaptation process to a stress of a novel homeostatic condition. Further investigations, at different times after the end of the exercise, could be useful to understand if HSP70 may be considered a new approach to monitoring exercise training and adaptive mechanisms in horses.

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“…Exercise-induced cytokine release (e.g., IL-6) could also be associated with alterations in extracellular HSP levels that can stimulate anabolic responses (Noble et al, 2008;Pedersen, 2011). Most HSPs are intracellular proteins that bind to nascent peptides and proteins that facilitate proper assembly and folding (Benini et al, 2015). Increases in concentrations of HSPs protect against protein denaturation and cell death caused by adverse environmental conditions including heat stress (Calderwood et al, 2007;Noble et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to heat stress modulates circulating levels of catecholamines (Febbraio, 2001), testosterone, cortisol (Vingren et al, 2016), and extracellular heat shock protein (HSP) (Benini et al, 2015). Exercise under heated environmental conditions can lead to dehydration due to changes in plasma volume caused by sweating and transient fluid movement into and out of the intravascular space (Zouhal et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Resistance Exercise in a Hot Environment Alters Serum Markers in Untrained Males

et al. 2020

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Purpose: We examined the effects of moderate resistance exercise (RE) on serum cortisol, testosterone, extracellular heat shock protein (HSP70), and interleukin (IL)-6 and IL-15 concentrations in untrained males in a hot environment. Methods: Ten untrained young males (26 ± 3 years; 75.8 ± 6 kg; 177.4 ± 5.3 cm) performed two series of full body RE [3 sets of 8 to 10 repetitions, 30-60 s recovery between series with 70% of one maximal repetition (1-RM), with a rest period of 1 to 3 min between exercises] carried out in a random order in both heated (∼35 • C) and thermoneutral (22 • C) conditions. Serum concentrations of testosterone, cortisol, HSP70, and IL-6 and IL-15 were measured before, at the end, and 1 h after RE sessions. Participants in both groups consumed 4 ml of water/kg body mass every 15 min. Results: There were time-related changes in testosterone, HSP70, and IL-6 (P < 0.001), and cortisol and IL-15 (P < 0.05). Levels of cortisol, HSP70, and IL-6 increased immediately for RE at 35 • C, and testosterone and IL-15 levels were decreased. Changes in serum testosterone, HSP70, cortisol, and IL-15 and IL-6 levels were reversed after 1 h. A significant time × condition interaction was observed for IL-15 and HSP70 (P < 0.001), cortisol and IL-6 (P < 0.05), but not for testosterone (P > 0.05). Conclusion: RE in a heated environment may not be appropriate for achieving muscle adaptations due to acute changes of hormonal and inflammatory markers.

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Influence of sex on cytokines, heat shock protein and oxidative stress markers in response to an acute total body resistance exercise protocol

Abstract: Acute total body resistance exercise altered circulating levels of IL-6 and sex differences existed in the temporal pattern and magnitude of this response.

Cited by 23 publications

References 33 publications

Differential inflammatory response of men and women subjected to an acute resistance exercise

Differential inflammatory response of men and women subjected to an acute resistance exercise

Serum Heat Shock Protein (HSP70) Changes In Horses After An Acute Exercise

Resistance Exercise in a Hot Environment Alters Serum Markers in Untrained Males

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