Influence of several biodegradable components added to pure and nanosilver-doped PMMA bone cements on its biological and mechanical properties

Wekwejt, Marcin; Michalska‐Sionkowska, Marta; Bartmański, Michał; Nadolska, Małgorzata; Łukowicz, Krzysztof; Pałubicka, Anna; Osyczka, Anna M.; Zieliński, Andrzej

doi:10.1016/j.msec.2020.111286

Cited by 32 publications

(28 citation statements)

References 103 publications

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“…The presence of up to 20 wt.% of CS, besides, favored the bioactivity of the ABCs by increasing the Ca and P ions deposited on its surface when being immersed in a simulated biological fluid (SBF) for different periods [100], decreased the T max and increased the t set , and improved the surface wettability [45,100]. Additionally, the implantation in Wistar rats' parietal bone showed an increase in the cement's osseointegration with CS.…”

Section: Bioactivity In Acrylic Bone Cements Loaded With Chitosanmentioning

confidence: 99%

“…The physical properties of CS depend on parameters such as molecular weight (Mw) and deacetylation degree (DD) (in the range of 50-95%) [40,41]. It is biodegradable, biocompatible, promotes cell growth and the deposition of a mineral-rich matrix by osteoblasts, is easily soluble in diluted acid solutions with pH less than 6, is antioxidant, presents antimicrobial, antifungal, and antitumor activities, is mucoadhesive, and is analgesic [34,[38][39][40][41][42][43][44][45][46].…”

Section: Chitosan (Cs)mentioning

confidence: 99%

“…In the last years, there has been a great interest in reinforcing polymeric matrices with nanomaterials to generate biocompatible and antibacterial nanocomposites [154]. In the case of CS, it is found that it has an excellent antimicrobial activity, and it is improved against a wide range of Gram-positive and Gram-negative bacteria with the incorporation of nanoparticles, such as zinc oxide (ZnO) [155,156], Au [4,157], Ag [45,158,159], and reduced GO [94]. Some of these nanocomposites in ABCs demonstrated improvement in antibacterial activity compared to CS alone [4,45].…”

Section: Antibacterial Effect Of Chitosan In Acrylic Bone Cementsmentioning

confidence: 99%

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The Role of Chitosan and Graphene Oxide in Bioactive and Antibacterial Properties of Acrylic Bone Cements

2020

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Acrylic bone cements (ABC) are widely used in orthopedics for joint fixation, antibiotic release, and bone defect filling, among others. However, most commercially available ABCs exhibit a lack of bioactivity and are susceptible to infection after implantation. These disadvantages generate long-term loosening of the prosthesis, high morbidity, and prolonged and expensive treatments. Due to the great importance of acrylic bone cements in orthopedics, the scientific community has advanced several efforts to develop bioactive ABCs with antibacterial activity through several strategies, including the use of biodegradable materials such as chitosan (CS) and nanostructures such as graphene oxide (GO), with promising results. This paper reviews several studies reporting advantages in bioactivity and antibacterial properties after incorporating CS and GO in bone cements. Detailed information on the possible mechanisms by which these fillers confer bioactive and antibacterial properties to cements, resulting in formulations with great potential for use in orthopedics, are also a focus in the manuscript. To the best of our knowledge, this is the first systematic review that presents the improvement in biological properties with CS and GO addition in cements that we believe will contribute to the biomedical field.

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Section: Bioactivity In Acrylic Bone Cements Loaded With Chitosanmentioning

confidence: 99%

Section: Chitosan (Cs)mentioning

confidence: 99%

Section: Antibacterial Effect Of Chitosan In Acrylic Bone Cementsmentioning

confidence: 99%

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The Role of Chitosan and Graphene Oxide in Bioactive and Antibacterial Properties of Acrylic Bone Cements

2020

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“…Currently, research in this field has gathered the best evidence for an adequate selection of antibiotics available especially for staphylococcal species, while, for other bacteria, such as streptococci, enterococci, or Gram-negative, the selection of antibiotics is more complex [10]. Different antibacterial agents were used by researchers for obtaining modified PMMA bone cements with antibacterial properties: antibiotics [11][12][13][14][15][16][17][18][19][20][21], silver nanoparticles [22][23][24][25], gold nanoparticles [26], hydroxyapatite [27][28][29][30][31], graphene [32,33], essential oil [34][35][36][37][38][39][40][41][42], or essential oils incorporated in different materials [43][44][45][46]. A schematic representation of cement preparation procedure is shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Additives Imparting Antimicrobial Properties to Acrylic Bone Cements

et al. 2021

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PMMA bone cements are mainly used to fix implanted prostheses and are introduced as a fluid mixture, which hardens over time. The problem of infected prosthesis could be solved due to the development of some new antibacterial bone cements. In this paper, we show the results obtained to develop four different modified PMMA bone cements by using antimicrobial additives, such as gentamicin, peppermint oil incorporated in hydroxyapatite, and silver nanoparticles incorporated in a ceramic glass matrix (2 and 4%). The structure and morphology of the modified bone cements were investigated by SEM and EDS. We perform experimental measurements on wettability, hydration degree, and degradation degree after immersion in simulated body fluid. The cytotoxicity was evaluated by MTT assay using the human MG-63 cell line. Antimicrobial properties were checked against standard strains Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. The addition of antimicrobial agents did not significantly affect the hydration and degradation degree. In terms of biocompatibility assessed by the MTT test, all experimental PMMA bone cements are biocompatible. The performance of bone cements with peppermint essential oil and silver nanoparticles against these two pathogens suggests that these antibacterial additives look promising to be used in clinical practice against bacterial infection.

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“…Usually, GO attracts significant attention in biomedical applications due to its high mechanical performance, biocompatibility, biodegradation [26,[28][29][30][31], and excellent antibacterial properties [32,33]. Some fillers such as hydroxyapatite (HA) [14][15][16][17], phosphate bioglasses [18,19], silicate and borate bioglasses [20,21], tricalcium phosphates [22,23], Sepia Officinalis cuttlebone [24], and biodegradable polymers such as cellulose, chitosan, polydioxanone [25], polylactic acid (PLA), β-polyhydroxy butyrate (PHB), and thermoplastic starch (TPS) have been added to the solid phase of the cement for improving different properties; however, due to the inorganic nature of some of them and the biodegradable behavior of others, losses in their mechanical properties have been generated [26].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Mechanical and Setting Properties in Acrylic Bone Cements Added with Graphene Oxide

et al. 2021

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The extended use of acrylic bone cements (ABC) in orthopedics presents some disadvantages related to the generation of high temperatures during methyl methacrylate polymerization, thermal tissue necrosis, and low mechanical properties. Both weaknesses cause an increase in costs for the health system and a decrease in the patient’s quality of life due to the prosthesis’s loosening. Materials such as graphene oxide (GO) have a reinforcing effect on ABC’s mechanical and setting properties. This article shows for the first time the interactions present between the factors sonication time and GO percentage in the liquid phase, together with the percentage of benzoyl peroxide (BPO) in the solid phase, on the mechanical and setting properties established for cements in the ISO 5833-02 standard. Optimization of the factors using a completely randomized experimental design with a factorial structure resulted in selecting nine combinations that presented an increase in compression, flexion, and the setting time and decreased the maximum temperature reached during the polymerization. All of these characteristics are desirable for improving the clinical performance of cement. Those containing 0.3 wt.% of GO were highlighted from the selected formulations because all the possible combinations of the studied factors generate desirable properties for the ABC.

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Influence of several biodegradable components added to pure and nanosilver-doped PMMA bone cements on its biological and mechanical properties

Cited by 32 publications

References 103 publications

The Role of Chitosan and Graphene Oxide in Bioactive and Antibacterial Properties of Acrylic Bone Cements

The Role of Chitosan and Graphene Oxide in Bioactive and Antibacterial Properties of Acrylic Bone Cements

Additives Imparting Antimicrobial Properties to Acrylic Bone Cements

Optimization of Mechanical and Setting Properties in Acrylic Bone Cements Added with Graphene Oxide

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