Influence of Serum Vitamin D Levels on Survival Rate and Marginal Bone Loss in Dental Implants: A Systematic Review

Bazal-Bonelli, Santiago; Sánchez-Labrador, Luis; Brinkmann, Jorge Cortés-Bretón; Cobo-Vázquez, Carlos; Martínez-Rodríguez, Natalia; Beca-Campoy, Tomás; Santos-Marino, Juan; Rodríguez-Fernández, Emilio; Alvarado-Lorenzo, Mario

doi:10.3390/ijerph191610120

Cited by 14 publications

(13 citation statements)

References 46 publications

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“…Moreover, significant differences were reported among the three groups regarding their MBL: 1.38 ± 0.33 mm in group 1 (deficient vitamin D levels), 0.89 ± 0.16 mm in group 2 (insufficient vitamin D levels), and 0.78 ± 0.12 mm in group 3 (sufficient vitamin D levels) 404 . MBL in groups of patients with sufficient and insufficient serum vitamin D levels were within the margins of physiological marginal bone loss, while MBL was higher in patients with a deficiency of vitamin D, and this deficiency seems to increase physiological marginal bone loss 403 …”

Section: Diet‐related Factors Altering Bone Metabolismmentioning

confidence: 82%

“…404 MBL in groups of patients with sufficient and insufficient serum vitamin D levels were within the margins of physiological marginal bone loss, while MBL was higher in patients with a deficiency of vitamin D, and this deficiency seems to increase physiological marginal bone loss. 403 Vitamin D intake was also associated with a reduction in mesial and distal marginal bone loss in a retrospective study on osteoporosis and dental implants. 405 Vitamin D supplementation seems to have positive effects on peri-implant bone formation.…”

Section: Vitamindmentioning

confidence: 99%

“…The small number of clinical trials and their limited number of patients make it necessary to carry out future research to clarify the specific role of vitamin D deficiencies 402 . Conclusions from other systematic reviews were the opposite: serum vitamin D levels in patients may play a relevant role in osseointegration, marginal bone loss, and dental implant survival 403 …”

Section: Diet‐related Factors Altering Bone Metabolismmentioning

confidence: 99%

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Emerging factors affecting peri‐implant bone metabolism

Insua,

Galindo‐Moreno,

Miron

et al. 2023

Periodontology 2000

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Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This is attributed in part to the advancements in material sciences that have led toward improvements in implant surface technology and characteristics. Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting bone metabolism. Among these patients, smokers are known to have impaired bone metabolism and thus be subject to higher risks of early implant failure and/or late complications related to the stability of the peri‐implant bone and mucosal tissues. Notably, however, emerging data have unveiled other critical factors affecting osseointegration, namely, those related to the metabolism of bone tissues. The aim of this review is to shed light on the effects of implant‐related factors, like implant surface or titanium particle release; surgical‐related factors, like osseodensification or implanted biomaterials; various drugs, like selective serotonin reuptake inhibitors, proton pump inhibitors, anti‐hypertensives, nonsteroidal anti‐inflammatory medication, and statins, and host‐related factors, like smoking, diet, and metabolic syndrome on bone metabolism, and aseptic peri‐implant bone loss. Despite the infectious nature of peri‐implant biological complications, these factors must be surveyed for the effective prevention and management of peri‐implantitis.

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Section: Diet‐related Factors Altering Bone Metabolismmentioning

confidence: 82%

Section: Vitamindmentioning

confidence: 99%

Section: Diet‐related Factors Altering Bone Metabolismmentioning

confidence: 99%

See 1 more Smart Citation

Emerging factors affecting peri‐implant bone metabolism

Insua,

Galindo‐Moreno,

Miron

et al. 2023

Periodontology 2000

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“…En una revisión sistemática se evaluó la oseointegración de implantes dentales, tomando en cuenta la pérdida ósea marginal y la tasa de supervivencia en relación con los niveles séricos de vitamina D, cuatro estudios incluyeron a 1,129 pacientes y recibieron 1,984 implantes dentales, se comparó la remodelación ósea durante la oseointegración, pérdida ósea y la supervivencia del implante y al mismo tiempo se realizaron pruebas para medir los niveles de vitamina D en el organismo, los resultados arrojaron que los pacientes suplementados experimentaron menor pérdida ósea que los pacientes que no lo recibieron. 20 En otro estudio realizado en ratas, se sometieron a una ingesta nula de vitamina D durante ocho semanas y otro grupo con administración de seis semanas a las que se les colocaron miniimplantes en la tibia y posteriormente se sometieron a la toma de muestra para realizar análisis de sangre e histomorfométricos, cuyos resultados establecen que la insuficiencia de la vitamina D causa una reducción significativa en sangre y al tener una deficiencia se asoció con una disminución de oseointegración, a estos resultados se les atribuye que la deficiencia tuvo un impacto directo en la neoformación de hueso periimplantario, por lo que se sugiere una compensación con vitamina D para mejorar la integración ósea directa del implante. 21 Este estudio proporciona una evidencia sobre el posible efecto que se puede llevar a cabo en la implantología y la suplementación de vitamina D con el fin de mejorar la calidad de hueso y la respuesta inmune del organismo.…”

Section: Discussionunclassified

Niveles bajos de vitamina D y su efecto en la oseointegración: revisión sistemática.

Xicoténcatl¹,

Flores²

2023

Revista De La Asociación Dental Mexicana

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Introduction: vitamin D is a hormone that is synthesized by skin cells using UV light and consumed through the diet. The relationship established between vitamin D deficiency and the failure of bone grafts or implants is based on immunological and inflammatory alterations due to the intimate link with innate and adaptive immunity. Objective: to identify the factors that occur in the periodontium when there are low levels of vitamin D and periodontal treatments such as bone grafts and implants are performed. Material and methods: a search for articles was carried out in PubMed and Google Scholar (Spanish and English). Results: vitamin D affects and predisposes to graft rejection, absence of osseointegration in implants due to immunomodulation. Conclusion: the success of the treatment becomes predictable when optimal levels of vitamin D are found together with the correct surgical approach techniques that allow the generation of an ideal integration of the periodontal tissues.

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“…Cases with lower serum vitamin D levels had slightly worse results in terms of marginal bone loss. Longer follow-up periods are needed to determine whether serum vitamin D levels affect implant survival rates and osseointegration over time [18].…”

Section: Major Findingsmentioning

confidence: 99%

Main factors of bone loss and the processes of osseointegration for dental implant: a systematic review

Carneiro¹,

Flausino²,

Franco³

et al. 2023

MedNEXT

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Introduction: In the cellular, molecular and structural scenario for dental implants, primary or mechanical stability in implant dentistry is considered a prerequisite for successful osseointegration. The alveolar bone architecture of the implant drilling site dictates the success of anchored endosteal implants. Objective: It was to carry out a systematic review to highlight the main variables that can compromise bone formation and osseointegration for dental implants. Methods: The systematic review rules of the PRISMA Platform were followed. The search was carried out from October to December 2022 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using articles from 2010 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 220 articles were found, and 65 articles were evaluated in full and 22 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 45 studies with a high risk of bias and 92 studies that did not meet GRADE. The success of the prosthetic restoration supported by osseointegrated implants and the health of the surrounding tissues, such as the reduction of bone loss, are closely related to the precision and adaptation of the components, the stability of the implant/abutment interface, as well as the resistance of this interface when it is subjected to loads during masticatory function. It is necessary to provide a complete understanding of the biological events that occur during osseointegration. Factors that can compromise bone healing are cholesterol, hyperlipidemia, and low vitamin D intake. Furthermore, the prominent influence of osteocytes and immune cells is influenced as being the main regulators during osseointegration and maintenance of the dental implant.

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Influence of Serum Vitamin D Levels on Survival Rate and Marginal Bone Loss in Dental Implants: A Systematic Review

Cited by 14 publications

References 46 publications

Emerging factors affecting peri‐implant bone metabolism

Emerging factors affecting peri‐implant bone metabolism

Niveles bajos de vitamina D y su efecto en la oseointegración: revisión sistemática.

Main factors of bone loss and the processes of osseointegration for dental implant: a systematic review

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