Influence of Serum Levels of Thyroid-Stimulating Hormone and Anti-Thyroid Peroxidase Antibodies, Age and Gender on Depression as Measured by the Zung Self-Rating Depression Scale

Shinkov, Alexander; Borisova, Anna-Maria I.; Kovacheva, R; Vlahov, Yordan; Dakovska, Lilia; Atanassova, Iliana; Petkova, Polina L.; Aslanova, Nina; Vukov, Mircho

doi:10.2478/folmed-2014-0004

Cited by 6 publications

(9 citation statements)

References 22 publications

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“…To analyze group differences in demographic and clinical variables, we performed analysis of variance [ 38 ] for continuous variables (i.e., age, TICV, and HDRS scores) and chi-squared tests for categorical variables (i.e., sex, educational level, family history, mood state, and drug treatment). We also performed t-tests to compare illness duration and psychiatric scale scores, including the YMRS, Korean version of the Mood Disorder Questionnaire, Hamilton Anxiety Rating Scale, and Barratt Impulsiveness Scale scores, between the BD I and BD II groups.…”

Section: Methodsmentioning

confidence: 99%

Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders

Woo

Kang

et al. 2021

Psychiatry Investig

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Objective Although bipolar II disorder (BD II) is not simply a mitigated form of bipolar I disorder (BD I), their neurobiological differences have not been elucidated. The present study aimed to explore cortical thickness (CT) and surface area (SA) in patients with BD I and BD II and healthy controls (HCs) to investigate the shared and unique neurobiological mechanisms of BD subtypes.Methods We enrolled 30 and 44 patients with BD I and BD II, respectively, and 100 HCs. We evaluated CT and SA using FreeSurfer and estimated differences in CT and SA among the three groups (BD I vs. BD II vs. HC). We adjusted for age, sex, educational level, and intracranial volume as confounding factors.Results We found widespread cortical thinning in the bilateral frontal, temporal, and occipital regions; cingulate gyrus; and insula in patients with BD. Alterations in SA, including increased SA of the pars triangularis and decreased SA of the insula, were noted in patients with BD. Overall, we found BD II patients demonstrated decreased SA in the right long insula compared to BD I patients.Conclusion Our results suggest that decreased SA in the right long insula is crucial for differentiating BD subtypes.

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Section: Methodsmentioning

confidence: 99%

Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders

Woo

Kang

et al. 2021

Psychiatry Investig

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“…This finding was supported by the results of a cohort study showed that about 69% (n=44) out of 64 untreated hyperthyroid had depression and 46% (n=29) from this group had persisted depression even after the treatment (7). This is in contrast to the findings reported from the three descriptives studies which found that the high prevalence of depression was among hypothyroid patients (45,47,48). Furthermore, the significant correlation between depression and type of thyroid disorders found (p=0.01) (46).…”

Section: Discussionmentioning

confidence: 58%

“…It means the higher of the TSH level, the stronger to had depression. This evidence was supported by population-based at Bulgaria that showed the significant association between the TSH level and depression was among participants who had high level of TSH (p=0.026) (48). However, some studies were failed to showed the association between these two variables (1,2,49).…”

Section: Discussionmentioning

confidence: 82%

Depression Level Among Thyroid Disorder Patients and Its Correlation

Jaafar

Saidi

Daud

et al. 2021

Int J Care Scholars

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Objective: Patients with thyroid disorders were found to experience depression due to several factors. The aims of this study was to measure depression level among thyroid disorder patients and examine the correlation between depression and Thyroid Stimulating Hormone (TSH) and free Thyroxine (fT4), stressful life events and social support level. Methods: A cross sectional study was carried out at one of the non-profit hospital at central region of Peninsular Malaysia. 153 thyroid patients were selected by using simple random sampling technique. The ethical approval was sought from IIUM Research Ethics Committee (IREC563) and the Medical Research and Ethics Committee (MREC) (NMRR-15-2127-28667). Several tools were used in this study including Depression Anxiety Stress Scale-42 (DASS-42), list of Life Threatening Experiences (LTE), Multidimensional Scale of Perceived Social Support (MSPSS); and Thyroid Function Test including TSH and fT4 were reviewed from the patient’s file. A correlation test was used to analyse the data by using SPSS version 21.0. Results: About 15% (n=23) out of 153 thyroid disorder patients had varies degree of depression (males - 7.8% (n=3) and females – 17.3% (n=20)). Also, there were positive correlation between depression and TSH (r=0.235, p=0.03), stressful life events (r=0.264, p=0.001) and negative correlation (r=-0.068, p=0.402) with perceived social support from family. Conclusion: These findings suggested that thyroid disorder patients had depression and the factors associated with depression were high TSH level, recent stressful life events and low social support from the family. These factors can be considered while assessing thyroid disorder patients who had symptoms of depression.

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“…After exclusion of duplicates, 3372 were screened and out of those, 62 were assessed for eligibility in full text. Fifteen studies [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] are included in this meta-analysis (PRISMA flowchart, Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…In fourteen studies effects for both, hyper-and hypothyroidism were reported [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. Thomsen et al published corresponding data on hypothyroidism in a separate study [46].…”

Section: Resultsmentioning

confidence: 99%

Hyperthyroidism and clinical depression: a systematic review and meta-analysis

et al. 2022

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Hyperthyroidism and clinical depression are common, and there is preliminary evidence of substantial comorbidity. The extent of the association in the general population, however, has not yet been estimated meta-analytically. Therefore we conducted this systematic review and meta-analysis (registered in PROSPERO: CRD42020164791). Until May 2020, Medline (via PubMed), PsycINFO, and Embase databases were systematically searched for studies on the association of hyperthyroidism and clinical depression, without language or date restrictions. Two reviewers independently selected epidemiological studies providing laboratory or ICD-based diagnoses of hyperthyroidism and diagnoses of depression according to operationalized criteria (e.g. DSM) or to cut-offs in established rating scales. All data, including study quality based on the Newcastle-Ottawa Scale, were independently extracted by two authors. Odds ratios for the association of clinical depression and hyperthyroidism were calculated in a DerSimonian-Laird random-effects meta-analysis. Out of 3372 papers screened we selected 15 studies on 239 608 subjects, with 61% women and a mean age of 50. Relative to euthyroid individuals, patients with hyperthyroidism had a higher chance of being diagnosed with clinical depression: OR 1.67 ([95% CI: 1.49; 1.87], I2: 6%; prediction interval: 1.40 to 1.99), a result supported in a number of sensitivity and subgroup analyses. The OR was slightly less pronounced for subclinical as opposed to overt hyperthyroidism (1.36 [1.06; 1.74] vs. 1.70 [1.49; 1.93]). This comorbidity calls for clinical awareness and its reasons need investigation and may include neurobiological mechanisms, common genetic vulnerability and a generally heightened risk for clinical depression in patients with chronic somatic disorders.

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Influence of Serum Levels of Thyroid-Stimulating Hormone and Anti-Thyroid Peroxidase Antibodies, Age and Gender on Depression as Measured by the Zung Self-Rating Depression Scale

Abstract: The depressive score was higher in the females and increased with age. Hypothyroidism determined a higher risk of depression in the females.

Cited by 6 publications

References 22 publications

Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders

Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders

Depression Level Among Thyroid Disorder Patients and Its Correlation

Hyperthyroidism and clinical depression: a systematic review and meta-analysis

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