Influence of Sensation Seeking on Response to Alcohol Versus Placebo: Implications for the Acquired Preparedness Model

Scott, Caitlin; Corbin, William R.

doi:10.15288/jsad.2014.75.136

Cited by 17 publications

(25 citation statements)

References 41 publications

(60 reference statements)

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“…Findings also showed that ADHD symptoms predicted steeper increases in stimulation, but only on the ascending limb. In contrast to prior studies of sensation seeking and related personality traits (e.g., Erblich & Earleywine, 2003; Fillmore, et al, 2009; Leeman, et al, 2014; Scott & Corbin, 2014), sensation seeking did not moderate changes in subjective stimulation. Because the association of subjective stimulant or sedative effects with motivational indicators (e.g., craving, wanting) may have etiological relevance (King, et al, 2011), further laboratory studies of these associations, including the examination of individual or pharmacological (e.g., BAC limb) moderators, is likely important.…”

Section: Discussioncontrasting

confidence: 99%

Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses, and acute tolerance in late adolescence.

Hendershot¹,

Wardell²,

Strang³

et al. 2015

Experimental and Clinical Psychopharmacology

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Individual differences in acute alcohol effects on cognitive control and subjective responses—and acute tolerance to these effects—are implicated in the risk for heavy drinking and alcohol-related harms. Few studies have examined these effects in drinkers under age 21. Additionally, studies of acute tolerance typically involve bolus oral alcohol administration, such that estimates of tolerance are confounded with blood alcohol concentration (BAC) limb. The current study examined cognitive control and subjective responses in young heavy drinkers (n = 88, M = 19.8 years old [SD = 0.8]) during a single-session alcohol clamp protocol. Participants completed an intravenous alcohol session comprising an ascending limb (0 to 80mg% in 20 minutes) and a BAC plateau (80mg% for 80 minutes). Serial assessments included a cued go/no-go task and measures of stimulation, sedation and craving. Relevant individual difference factors (ADHD symptoms and sensation seeking) were examined as moderators. Multi-level modeling demonstrated that response inhibition worsened following initial rise in BAC and showed increasing impairment during the BAC plateau. ADHD symptoms and sensation seeking moderated this effect. Significant within-person associations between stimulation and craving were evident on the ascending limb only. Participants with higher ADHD symptoms reported steeper increases in stimulation during the ascending limb. These findings provide initial information about subjective and behavioral responses during pseudo-constant BAC, and potential moderators of these outcomes, in late adolescence. Additional studies with placebo-controlled designs are necessary to confirm these findings.

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Section: Discussioncontrasting

confidence: 99%

Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses, and acute tolerance in late adolescence.

Hendershot¹,

Wardell²,

Strang³

et al. 2015

Experimental and Clinical Psychopharmacology

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show abstract

“…This finding extends prior work (Brunelle et al, 2004; Erblich & Earleywine, 2003; Leeman et al, 2014; Scott & Corbin, 2014) and provides initial evidence for one mechanism by which personality influences drinking habits. However, important next steps are to determine whether the association of reward sensitivity and acute stimulation is best accounted for by the pharmacological and/or expectancy effects of alcohol, and, further, whether findings extend to more diverse samples and age groups and at varied doses of alcohol.…”

Section: Discussionsupporting

confidence: 85%

“…Of the various ways that personality promotes alcohol misuse (Littlefield & Sher, 2010), one that has gained increasing research attention is the contribution of personality to subjective response to alcohol (Erblich & Earleywine, 2003; Leeman et al, 2014; Scott & Corbin, 2014). Subjective response is implicated in virtually all theoretical models of alcohol misuse (Newlin & Renton, 2010; Schuckit, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…To date, most studies examining the association between personality and subjective response to alcohol have focused on traits such as sensation seeking (Scott & Corbin, 2014), impulsiveness (Leeman et al, 2014), and behavioral undercontrol (Erblich & Earleywine, 2003). However, factor analytic studies indicate that these traits are only modestly related to BIS- and BAS-mediated traits (Caseras, Ávila, & Torrubia, 2003; Depue & Collings, 1999; Franken & Muris, 2006; Quilty & Oakman, 2004; Zelenski & Larsen, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Acute subjective response to alcohol as a function of reward and punishment sensitivity

Morris

Treloar

Tsai

et al. 2016

Addictive Behaviors

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Individual differences in subjective response to alcohol play a crucial role in the development of heavy drinking and related problems. In light of this, a growing focus of research has been identifying factors that contribute to differences in response. The aim of the present study was to determine whether individual differences in the subjective experience of rewarding and aversive effects of alcohol are a specific manifestation of general differences in reward and punishment sensitivity. Eighty-nine participants (M age = 22.4, SD = 1.9; 47.2% women) consumed a moderate dose of alcohol, i.e., peak breath alcohol concentration (BrAC) ≈ 0.080 g%, and rated their level of stimulation and sedation at seven timepoints over the BrAC curve. Sensitivity to reward and punishment were assessed by a self-report questionnaire prior to consumption. Multilevel growth models showed that post-consumption changes in stimulation ratings varied as a function of participants’ level of reward and punishment sensitivity. Drinkers more sensitive to reward reported feeling more stimulated shortly after drinking and exhibited an attenuated rate of decline in stimulation over the blood alcohol curve, relative to drinkers with less strong reward sensitivity. Reward sensitivity was not related to subjective ratings of sedation, and punishment sensitivity was not related to either stimulation or sedation ratings. Findings suggest that reward sensitivity may increase risk for alcohol misuse among young adult social drinkers by increasing their subjective feelings of stimulation while drinking.

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“…Also, the present study focused on drinking motives as predictors of subjective responses to alcohol in order to test specific hypotheses informed by motivational theory that have not yet been fully examined. However, there are other individual difference factors that are known to influence subjective responses to alcohol, including alcohol expectancies, personality traits, and family history of alcoholism (Morean et al., ; Quinn and Fromme, ; Scott and Corbin, ). Future studies using larger samples will permit more comprehensive analyses of individual differences in subjective responses to alcohol.…”

Section: Discussionmentioning

confidence: 99%

Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis

Wardell

Ramchandani

Hendershot

2016

Alcoholism Clin & Exp Res

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Background Motivational models of alcohol use suggest that individual differences in sensitivity to the acute subjective effects of alcohol play an important role in motivational pathways to alcohol use. However, few studies have examined the link between drinking motives and subjective responses to alcohol. This study investigated the associations of coping and enhancement drinking motives with subjective stimulant and sedative effects during a laboratory alcohol administration session. We also examined whether stimulation and sedation following alcohol administration mediated the relationships between drinking motives and post-alcohol ratings of alcohol wanting and liking. Methods Heavy episodic drinkers (n=147, ages 19–25) at two sites participated in an intravenous alcohol administration session in which blood alcohol concentration was raised to a target of 80mg% over 20 min. Participants completed measures of stimulation and sedation at baseline and 20 min, and also rated alcohol liking and wanting at 20 min. Drinking motives and alcohol use were assessed during a previous laboratory visit. Results A path analysis controlling for baseline stimulation and sedation showed that enhancement motives were positively associated with post-alcohol stimulation and negatively associated with post-alcohol sedation. In contrast, coping motives were positively associated with post-alcohol sedation. In turn, post-alcohol stimulation, but not sedation, was associated with alcohol wanting and liking. Further, indirect pathways from enhancement motives to post-alcohol wanting and liking mediated through post-alcohol stimulation were statistically significant. Coping motives, on the other hand, were directly associated with increased post-alcohol wanting and liking. Conclusions The results demonstrate that drinking motives are linked with individual differences in sensitivity to the effects of alcohol, which may serve as a mechanism underlying alcohol reinforcement and the motivation to consume more alcohol during a drinking episode.

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Influence of Sensation Seeking on Response to Alcohol Versus Placebo: Implications for the Acquired Preparedness Model

Cited by 17 publications

References 41 publications

Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses, and acute tolerance in late adolescence.

Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses, and acute tolerance in late adolescence.

Acute subjective response to alcohol as a function of reward and punishment sensitivity

Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis

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