Influence of semipurified diets on atherosclerosis in African green monkeys

Kritchevsky, David; Davidson, Larry M.; Kim, Hong; Krendel, David A.; Malhotra, Saroj; Watt, J.J. Vander; duPlessis, J.P.; Winter, P.A.D.; Ipp, Tania; Mendelsohn, D; Bersohn, I

doi:10.1016/0014-4800(77)90064-8

Cited by 39 publications

(4 citation statements)

References 29 publications

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“…Hypertension in these models shows deleterious effect on atherosclerosis development [354], thus they are extensively used to study the effects of hypertension on atherosclerosis [351,354,355]. African green monkey and other primates have been used to study the effects of oral contraceptives on plasma cholesterol [11,356,357]. The close resemblance of plasma lipoprotein-lipid level, plaque development and its calcification and mineralization with humans makes them an excellent model to study the correlation between plasma lipids and plaque development.…”

Section: Non-human Primatementioning

confidence: 99%

Models to Study Atherosclerosis: A Mechanistic Insight

Singh

Tiwari

Dikshit

et al. 2009

CVP

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The recent failure of candidate drugs like cholesterol ester transfer protein (CETP) and acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors calls for a revised approach for screening anti-atherosclerotic drugs and development of new models of atherosclerosis. For this it is important to understand the mechanism of the disease in a particular model. Models simultaneously showing hyperlipidemia, inflammation and associated complications of diabetes and hypertension will serve the purpose better as they mimic the actual clinical condition. Besides this, analyzing candidate molecules in vivo, in vitro and at various levels of atherosclerosis progression is important. Models based on various cells and process involved in atherosclerosis should be used for screening candidate molecules. The challenge lies in bridging the gap between genetically friendly small animal and human-like bigger animal models. Sequencing of the mouse and human genome, development of a single nucleotide polymorphism (SNP) database and in silico quantitative trait loci (QTL) linkage analysis may enhance the understanding of atherosclerosis and help develop new therapeutic targets.

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Section: Non-human Primatementioning

confidence: 99%

Models to Study Atherosclerosis: A Mechanistic Insight

Singh

Tiwari

Dikshit

et al. 2009

CVP

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“…When baboons (Kritchevsky et al, 1974) and vervet monkeys (Kritchevsky et al, 1977) were fed with a semipurified diet containing fructose, sucrose, starch or glucose without the addition of cholesterol, the most severe aortic sudanophilia was observed in the fructose diet group. It is wellknown that a fructose-containing diet can induce mild hypertension in rats (Hwang et al, 1987) and mongrel dogs (Martinez et al, 1994), but the hypertension itself rarely promotes the development of atherosclerosis in rats, rabbits and monkeys (Chobanian, 1983).…”

Section: Discussionmentioning

confidence: 98%

“…More convincingly, when baboons (Kritchevsky et al, 1974) and vervet monkeys (Kritchevsky et al, 1977) were fed with semipurified diet containing fructose, sucrose, starch or glucose in the absence of cholesterol, the most severe aortic sudanophilia was observed in the fructose diet group.…”

Section: Introductionmentioning

confidence: 92%

High fat and high fructose diet induced intracranial atherosclerosis and enhanced vasoconstrictor responses in non-human primate

et al. 2006

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“…We have been studying the effects of a semipurified, cholesterol-free diet which leads to atherosclerosis in rabbits [7,8] and sudanophilia in baboons [9] or vervet mon keys [10]. The diet contains 40% carbohy drate.…”

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confidence: 99%

Influence of Dietary Fiber on Aortic Sudanophilia in Vervet Monkeys

et al. 1981

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Vervet monkeys were fed a cholesterol-free, semipurified diet containing 40% sucrose, 25% casein, 14% coconut oil and 15% fiber for 23 weeks. The fibers used were cellulose, wheat straw or alfalfa. Serum lipid and lipoprotein levels were highest in the monkeys fed the cellulose-containing diet. Liver lipids were slightly higher in the cellulose-fed monkeys. The ratio of endogenous to exogenous cholesterol was estimated using isotopically labeled sterol and sterol precursor and found to be similar in all three groups. The levels of endogenous or exogenous cholesterol in the serum and liver of alfalfa-fed monkeys were lower than the levels in the other two groups, which were similar. The ratio of exogenous to endogenous cholesterol in the feces was highest in the monkeys fed alfalfa. Monkeys fed alfalfa exhibited the lowest lithogenic index. Cholesterol 7α-hydroxylase activity was highest in livers of monkeys fed wheat straw. The data suggest that alfalfa inhibits absorption and reabsorption of cholesterol more than wheat straw or cellulose. Monkeys fed cellulose exhibited more severe aortic sudanophilia than those fed the other two fibers.

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Influence of semipurified diets on atherosclerosis in African green monkeys

Cited by 39 publications

References 29 publications

Models to Study Atherosclerosis: A Mechanistic Insight

Models to Study Atherosclerosis: A Mechanistic Insight

High fat and high fructose diet induced intracranial atherosclerosis and enhanced vasoconstrictor responses in non-human primate

Influence of Dietary Fiber on Aortic Sudanophilia in Vervet Monkeys

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