Influence of Seminal Metals on Assisted Reproduction Outcome

Rodríguez-Díaz, Rubí; Blanes-Zamora, Raquel; Vaca-Sánchez, Rebeca; Gómez-Rodríguez, Jorge; Hardisson, Arturo; González-Weller, Dailos; Gutiérrez, Ángel J.; Paz, Soraya; Rubio, Carmen Quiñones; González‐Dávila, Enrique

doi:10.1007/s12011-022-03256-w

Cited by 9 publications

(7 citation statements)

References 47 publications

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“…Also, the increased levels of metal ions including Ca, Zn, Se, K and Mg in human seminal fluid (measured using plasma optical emission spectrometry) have been found to be significantly correlating with male fertility. 59 However, there is limited data on trace elements' impact on IVF success and current literature stresses the need for further investigation to enhance ART effectiveness. By delving deeper into the molecular mechanisms and interactions associated with seminal plasma analytes, we can potentially identify novel biomarkers or targets for intervention that may improve the outcomes of IVF procedures.…”

Section: Status Of Current Approaches In Augmenting the Assisted Repr...mentioning

confidence: 99%

“…In this study, a positive association of Se levels in seminal plasma with the probabilities of pregnancy and live birth was found. Also, the increased levels of metal ions including Ca, Zn, Se, K and Mg in human seminal fluid (measured using plasma optical emission spectrometry) have been found to be significantly correlating with male fertility 59 . However, there is limited data on trace elements’ impact on IVF success and current literature stresses the need for further investigation to enhance ART effectiveness.…”

Section: Status Of Current Approaches In Augmenting the Assisted Repr...mentioning

confidence: 99%

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Understanding seminal plasma in male infertility: emerging markers and their implications

Vashisht,

Gahlay

2023

Andrology

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Infertility affects a significant proportion of the reproductive‐aged population, with male‐associated factors contributing to over half of the cases. However, current diagnostic tools have limitations, leading to an underestimation of the true prevalence of male infertility. While traditional semen parameters provide some insights, they fail to determine the true fertility potential in a substantial number of instances. Therefore, it is crucial to investigate additional molecular targets responsible for male infertility to improve understanding and identification of such cases. Seminal plasma, the main carrier of molecules derived from male reproductive glands, plays a crucial role in reproduction. Amongst its multifarious functions, it regulates processes such as sperm capacitation, sperm protection and maturation, and even interaction with the egg's zona pellucida. Seminal plasma offers a non‐invasive sample for urogenital diagnostics and has shown promise in identifying biomarkers associated with male reproductive disorders. This review aims to provide an updated and comprehensive overview of seminal plasma in the diagnosis of male infertility, exploring its composition, function, methods used for analysis, and the application of emerging markers. Apart from the application, the potential challenges of seminal plasma analysis such as standardisation, marker interpretation and confounding factors have also been addressed. Moreover, we have also explored future avenues for enhancing its utility and its role in improving diagnostic strategies. Through comprehensive exploration of seminal plasma's diagnostic potential, the present analysis seeks to advance the understanding of male infertility and its effective management.

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Section: Status Of Current Approaches In Augmenting the Assisted Repr...mentioning

confidence: 99%

Section: Status Of Current Approaches In Augmenting the Assisted Repr...mentioning

confidence: 99%

Understanding seminal plasma in male infertility: emerging markers and their implications

Vashisht,

Gahlay

2023

Andrology

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“…In 2022, Rodríguez-Díaz et al [ 73 ] analyzed the influence of 22 metals in the seminal plasma on sperm quality, as well as fertilization effects, such as the pregnancy rate, implantation, and embryo quality. The importance of Na, K, Ca, and Mg, in particular, has been described [ 74 ], in addition to the role of Fe and Zn [ 75 ].…”

Section: Male Reproductive Toxicity Of Micronutrient Metalsmentioning

confidence: 99%

“…In a study by Rodríguez-Díaz et al [ 73 ], a significant relationship was discovered between higher Zn levels and better seminal quality. The higher Zn concentrations were observed in men with normal spermiograms with higher sperm counts (95.42 ± 62.39 mg/kg), while pathological changes and decreased concentrations were observed when the Zn concentration was lower (71.18 ± 35.082 mg/kg).…”

Section: Male Reproductive Toxicity Of Micronutrient Metalsmentioning

confidence: 99%

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An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility

Maciejewski

Radzikowska-Büchner²,

Flieger

et al. 2022

IJERPH

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Numerous factors affect reproduction, including stress, diet, obesity, the use of stimulants, or exposure to toxins, along with heavy elements (lead, silver, cadmium, uranium, vanadium, mercury, arsenic). Metals, like other xenotoxins, can cause infertility through, e.g., impairment of endocrine function and gametogenesis or excess production of reactive oxygen species (ROS). The advancement of nanotechnology has created another hazard to human safety through exposure to metals in the form of nanomaterials (NMs). Nanoparticles (NPs) exhibit a specific ability to penetrate cell membranes and biological barriers in the human body. These ultra-fine particles (<100 nm) can enter the human body through the respiratory tract, food, skin, injection, or implantation. Once absorbed, NPs are transported to various organs through the blood or lymph. Absorbed NPs, thanks to ultrahigh reactivity compared to bulk materials in microscale size, disrupt the homeostasis of the body as a result of interaction with biological molecules such as DNA, lipids, and proteins; interfering with the functioning of cells, organs, and physiological systems; and leading to severe pathological dysfunctions. Over the past decades, much research has been performed on the reproductive effects of essential trace elements. The research hypothesis that disturbances in the metabolism of trace elements are one of the many causes of infertility has been unquestionably confirmed. This review examines the complex reproductive risks for men regarding the exposure to potentially harmless xenobiotics based on a series of 298 articles over the past 30 years. The research was conducted using PubMed, Web of Science, and Scopus databases searching for papers devoted to in vivo and in vitro studies related to the influence of essential elements (iron, selenium, manganese, cobalt, zinc, copper, and molybdenum) and widely used metallic NPs on male reproduction potential.

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The Influence of Follicular Fluid Metals on Assisted Reproduction Outcome

Rodríguez-Díaz

Blanes-Zamora

Paz-Montelongo

et al. 2023

Biol Trace Elem Res

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Infertility has become more common, with an increased exposure to toxic compounds including heavy metals (HM). Follicular fluid (FF) surrounds the developing oocyte in the ovary and can be analysed to assess metal content. The levels of twenty-two metals were measured in the FF of ninety-three females in a reproduction unit, and their influence on assisted reproduction technique (ART), were examined. The metals were determined by optical emission spectrophotometry. Low values of copper, zinc, aluminium, and calcium favour polycystic ovary syndrome. The relationships between the number of oocytes and metals: iron (rs=0.303; p=0.003) and calcium (rs=−0.276; p=0.007) are significant, as well as between the number of mature oocytes with iron (rs=0.319; p=0.002), calcium (rs=−0.307; p=0.003) and sodium (rs=−0.215; p=0.039) and are near to significance in the case of aluminium (rs=−0.198; p=0.057). In the group with a fertilisation rate ≤ 75%, 36% of the women presented calcium >176.62 mg/kg compared to the group with a fertilisation rate ≥ 75% where this percentage was only 10% (p=0.011). An excess of iron and calcium reduces the good quality embryo rate, and an excess of potassium impairs the blastocyst rate. If potassium is above 237.18 mg/kg and calcium is below 147.32 mg/kg, these conditions favour embryo implantation. Pregnancy is influenced by high potassium and low copper levels. Controlling exposure to toxic elements is recommended for all couples with reduced fertility or receiving an ART.

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Influence of Seminal Metals on Assisted Reproduction Outcome

Cited by 9 publications

References 47 publications

Understanding seminal plasma in male infertility: emerging markers and their implications

Understanding seminal plasma in male infertility: emerging markers and their implications

An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility

The Influence of Follicular Fluid Metals on Assisted Reproduction Outcome

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