Influence of selenium on antibody production in sheep

Larsen, H. J.; Moksnes, Knut; Øvernes, Gunnar

doi:10.1016/s0034-5288(18)30886-5

Cited by 43 publications

(28 citation statements)

References 15 publications

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“…The changes in serum IgG concentrations before and after calving were in accordance with the findings of others [22]. Larsen et al [23] indicated that dietary deficiencies of Se decrease IgG and IgM concentrations in plasma. Hidiroglou et al [14] reported there were no significant differences in the concentrations of IgG 1 and IgG 2 among VE supplemented and control calves.…”

Section: Discussionsupporting

confidence: 89%

“…It has also been reported that an adequate supply of Se alone or in combination with VE, in cows at late pregnancy, increased colostral and post-suckle serum IgG concentrations [33]. Dietary deficiencies of Se decrease IgG and IgM concentrations in plasma [23]. Parenteral administration of Se and VE to dairy cows in late stages of pregnancy does not influence changes in plasma IgG concentrations before and after calving [23].…”

mentioning

confidence: 99%

“…Dietary deficiencies of Se decrease IgG and IgM concentrations in plasma [23]. Parenteral administration of Se and VE to dairy cows in late stages of pregnancy does not influence changes in plasma IgG concentrations before and after calving [23]. A divergence of opinion regarding the effects of Se on hematological indicators was often presented in literature.…”

mentioning

confidence: 99%

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Effect of Prepartum Supplementation of Selenium and Vitamin E on Serum Se, IgG Concentrations and Colostrum of Heifers and on Hematology, Passive Immunity and Se Status of Their Offspring

Moeini

Kiani

Mikaeili

et al. 2011

Biol Trace Elem Res

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Forty heifers at the late stage of gestation were randomly assigned into five groups. Heifers were balanced for age, weight, and time of calving in each group. Four and 2 weeks before expected time of calving, the heifers were injected with 0 ml (C), 10 ml (T1), 20 ml (T2), 30 ml (T3), and 40 ml (T4) Se and VE supplements, respectively. Each milliliter of the supplement contained of 0.5 mg Se as sodium selenite and 50 IU of dl-alpha-tocopheryl acetate. Blood samples were collected from the heifers 4 weeks before expected calving and at calving day and from the calves at birth and 7 days of age. The serum Se and immunoglobulin G (IgG) concentrations, white blood cell and differential leukocyte counts were measured. The Se concentrations in the sera of the heifers before the injections of Se and VE supplements were the same among the groups (P > 0.05), but after calving were significantly increased in the treated heifers (P < 0.05). Similarly, the serum Se levels of calves of the treated heifers were higher (P < 0.05). The Se concentrations in the colostrums of the heifers were affected by treatments (P < 0.05). Colostrum and daily milk productions at 8-week lactation were increased in treated heifers compared with the controls (P < 0.05). Likewise, the milk somatic cell counts decreased in the treated heifers compared with the controls. The changes of the mean serum IgG levels did not differ among calves (P > 0.05). The white blood cell counts were higher in calves of heifers in groups T3 and T4 compared with the control group at 7 days of age (P < 0.05).

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

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Effect of Prepartum Supplementation of Selenium and Vitamin E on Serum Se, IgG Concentrations and Colostrum of Heifers and on Hematology, Passive Immunity and Se Status of Their Offspring

Moeini

Kiani

Mikaeili

et al. 2011

Biol Trace Elem Res

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“…Thus, a relatively narrow range of selenium concentrations must be maintained for optimal function of the immune system. 2,3,7,12,13,16,21,25,27,29,30,32 This study and results of a field investigation failed to clarify the association between subclinical selenium toxicosis and abortion/perinatal mortality. However, data from a limited number of animals suggest that current values indicative of perinatal selenium toxicosis (Ն3 ppm) may underestimate the resistance of animals to chronic selenium toxicosis and that marked elevations in hepatic selenium concentration (Ͼ9 ppm) may be clinically relevant.…”

Section: Discussionmentioning

confidence: 77%

The Effect of Subclinical Selenium Toxicosis on Pregnant Beef Cattle

et al. 1998

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Abstract. A field investigation conducted by the South Dakota Animal Disease Research and DiagnosticLaboratory suggested that subclinical selenium toxicosis in pregnant cows may have contributed to an outbreak of aborted/stillborn calves in a high-selenium region of South Dakota. This study was undertaken to evaluate the relationship between abortion and subclinical selenium toxicosis in the dam and to assess the effects of subclinical selenium toxicosis on the bovine immune system. Fifteen pregnant cows were fed diets containing 0.25 (control), 6.0, and 12.0 ppm selenium beginning at 80-110 days gestation. Although selenium toxicosis has been reported to cause abortion, this study failed to reproduce abortions. A single cow in the 12-ppm selenium treatment group gave birth to a weak calf, which subsequently died. This calf had myocardial lesions consistent with those described for selenium toxicosis and had hepatic selenium levels of 9.68 ppm (wet weight). Elevated dietary selenium resulted in the depression of several leukocyte function parameters in pregnant cows. A statistically significant depression in forced antibody response was identified in both selenium-supplemented groups. A significantly diminished mitogenic response to concanavalin A and pokeweed mitogen was also observed in the 12-ppm selenium group. Although a similar pattern of depression was also observed with phytohemagglutinin, differences were not significant. These findings indicate that even in the absence of clinical alkali disease, elevated selenium levels may adversely affect both pregnancy outcome and the bovine immune system.

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“…Thus, dietary supplementation of grazing sheep must also consider the integration of vitamins and minerals during the feeding in fold. Indeed, the supply of vitamins and trace elements to dairy ewes can not only prevent diseases associated with lack of nutrients but also increases the immune system (Larsen et al 1988), reduces the lambs' mortality (Van Metre and Callan 2001) mastitis, and milk somatic cell content (Morgante et al 1999), thereby improving ewes' reproductive performance (Hemingway 2003) and quality of products . Given this background, the aim of this study was to evaluate in grazing ewes, during the dry season in Mediterranean area, the influence of the addition of a vitamin-trace element complex on the quantitative and qualitative aspects of milk yield.…”

Section: Introductionmentioning

confidence: 99%

Vitamin and trace element supplementation in grazing dairy ewe during the dry season: effect on milk yield, composition, and clotting aptitude

Tufarelli

Petrera

Khan³

et al. 2011

Trop Anim Health Prod

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A study was carried out to evaluate the influence of vitamin and trace mineral supplementation on milk production and composition in grazing dairy ewes during the dry season. Ewes (n = 50) were assigned at weaning to blocks and treatments. Ewes were daily conducted (8 h/day) on a pasture based on Italian ryegrass (Lolium multiflorum). At fold, ewes received a basal diet composed by ad libitum oat hay and a definite amount of a pelleted concentrate. Dietary treatments included: (1) the control concentrate containing background of vitamin and trace mineral only, and (2) the experimental concentrate containing the premix supplement (10 g/kg of dry matter). Vitamin and trace mineral supplementation did not affect ewes' body weight. Milk, fat- and protein-corrected milk, fat percentage, and clotting properties were improved in ewes fed supplemented concentrate. There was a week × treatment interaction (P < 0.05) for yield of milk and corrected milk that was greatest at peak production in ewes fed the premix. Our findings indicate that in grazing dairy ewe, the dietary vitamin and trace mineral supplementation during dry season led to an increase of milk production and quality, with positive improvement in milk clotting aptitude.

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Influence of selenium on antibody production in sheep

Cited by 43 publications

References 15 publications

Effect of Prepartum Supplementation of Selenium and Vitamin E on Serum Se, IgG Concentrations and Colostrum of Heifers and on Hematology, Passive Immunity and Se Status of Their Offspring

Effect of Prepartum Supplementation of Selenium and Vitamin E on Serum Se, IgG Concentrations and Colostrum of Heifers and on Hematology, Passive Immunity and Se Status of Their Offspring

The Effect of Subclinical Selenium Toxicosis on Pregnant Beef Cattle

Vitamin and trace element supplementation in grazing dairy ewe during the dry season: effect on milk yield, composition, and clotting aptitude

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