Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders

Pradhan, Madhulika; Singh, Deependra; Singh, Manju Rawat

doi:10.3109/21691401.2014.955105

Cited by 57 publications

(19 citation statements)

References 28 publications

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“…The % EE equivalent to percentage of drug encapsulated within nanoparticles was determined by indirect method. CUR-SLNs dispersion (1.0 ml) were centrifuged at 17,000 rpm (32,368g) for 60 min using cooling centrifuge (Remi Elektrotechnik Ltd., REMI-C24 BL, Thane, Maharashtra, India), to distinct the lipid and aqueous phase [18,19]. The supernatant was diluted with methanol and analyzed by HPLC.…”

Section: % Ee and Drug Loadingmentioning

confidence: 99%

Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis

Shrotriya

Ranpise

Satpute

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Irritant contact dermatitis (ICD) and hyperpigmentation are the problems associated with skin. Topical curcumin (CUR) although effective in hyperpigmentation and ICD, is a challenging molecule due to low-solubility. Encapsulation of CUR into solid lipid nanoparticles (SLNs) makes it amenable to topical dosing as their small size promotes its penetration into the skin. CUR-SLNs were prepared using Precirol ATO5 and Tween-80 by probe ultrasonication method. Further, CUR-SLNs were incorporated into Carbopol gel and investigated for ex-vivo skin permeation, skin deposition and skin irritation studies. The potential of CUR-SLN gel was checked against hyperpigmentation through the inhibition of tyrosinase enzyme. It was further evaluated for possible effects on ICD using BALB/c mice. The optimized CUR-SLN showed the particle size of 51 nm and 93% EE. Ex vivo permeation of CUR-SLN gel exhibited controlled drug release up to 24 h, similarly in vitro drug deposition studies showed potential for skin targeting. In vitro tyrosinase inhibition assay indicates that the formulated gel has potential in skin depigmentation. The gel also confirmed proficient suppression of ear swelling and reduction in skin water content in the BALB/c mouse. Thus, the CUR-SLN gel would be a safe and effective alternative to conventional vehicles for treatment of ICD and pigmentation.

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Section: % Ee and Drug Loadingmentioning

confidence: 99%

Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis

Shrotriya

Ranpise

Satpute

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…NLC, as the second generation of lipid nanoparticles, consist of the mixture of solid lipid and liquid lipid. They not only possess the outstanding advantages of solid lipid nanoparticles, but also avoid the disadvantages such as drug leakage and low entrapment efficacy, which can be attributed to the incorporation of liquid lipid that breaks the ordered crystalline state of solid lipid and enlarges drug storage space (Iqbal et al 2012, Pradhan et al 2016. In addition, NLC possess a number of features advantageous for the topical route of application.…”

Section: Introductionmentioning

confidence: 99%

Optimization of nanostructured lipid carriers for topical delivery of nimesulide using Box–Behnken design approach

Moghddam

Ahad

Aqil

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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“…As shown in Figure 1 , by increasing the concentration of Tween 80, particle size would be reduced in the lowest amount of GMS. This phenomenon is due to a further reduction in interfacial tension and enhanced stabilization of particles by reduction of aggregation tendency as the result of higher concentrations of the surfactant [ 43 ]. In contrast, it was observed that with increasing the amount of GMS, the effect was reversed, and therefore, in the highest amount of GMS, the smallest particle size was achieved in the lowest concentration of Tween 80 (i.e., 0.5%).…”

Section: Resultsmentioning

confidence: 99%

Development of Perphenazine-Loaded Solid Lipid Nanoparticles: Statistical Optimization and Cytotoxicity Studies

Farsani

Mahjub

Mohammadi

et al. 2021

BioMed Research International

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Objective. Perphenazine (PPZ), as a typical antipsychotic medical substance, has the same effectiveness compared to atypical antipsychotic medications for the treatment of schizophrenia. Despite the lipophilic essence, PPZ encounters limited bioavailability caused by the first-pass metabolism following oral administration. In the present study, PPZ-containing solid lipid nanoparticles (PPZ-SLNs) were prepared and optimized based on different factors, including lipid and surfactant amount, to develop appropriate and safe novel oral dosage forms of PPZ. Methods. The solvent emulsification-evaporation method was utilized to form SLNs by using soybean lecithin, glycerol monostearate (GMS), and Tween 80. Statistical optimization was done by the Box-Behnken design method to achieve formulation with optimized particle size, entrapment efficiency, and zeta potential. Also, transmission electron microscopy, in vitro release behavior, differential scanning calorimetry (DSC), and powder X-ray diffractometry (P-XRD) studies and cytotoxicity studies were assessed. Results. Optimization exhibited the significant effect of various excipients on SLN characteristics. Our finding indicated that the mean particle size, zeta potential, and entrapment efficiency of optimized PPZ-SLN were, respectively, 104 ± 3.92 nm , − 28 ± 2.28 mV , and 83 % ± 1.29 . Drug release of PPZ-SLN was observed to be greater than 90% for 48 h that emphasized a sustained-release pattern. The DSC and P-XRD studies revealed the amorphous state of PPZ-SLN. FTIR spectra showed no incompatibility between the drug and the lipid. Performing cytotoxicity studies indicated no significant cytotoxicity on HT-29 cell culture. Conclusion. Our study suggests that PPZ-SLNs can make a promising vehicle for a suitable therapy of schizophrenia for the oral drug delivery system.

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Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders

Cited by 57 publications

References 28 publications

Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis

Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis

Optimization of nanostructured lipid carriers for topical delivery of nimesulide using Box–Behnken design approach

Development of Perphenazine-Loaded Solid Lipid Nanoparticles: Statistical Optimization and Cytotoxicity Studies

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