Influence of Seasonality and Public-Health Interventions on the COVID-19 Pandemic in Northern Europe

Quinn, Gerry A.; Connolly, Michael; Fenton, Norman E.; Hatfill, Steven J.; Hynds, Paul; ÓhAiseadha, Coilín; Sikora, Karol; Soon, Willie; Connolly, Ronan

doi:10.3390/jcm13020334

Cited by 5 publications

(1 citation statement)

References 120 publications

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“…Seasonal patterns in respiratory and enteric pathogenic virus infections have been observed ( 25 – 32 ). In the United States, the National Respiratory and Enteric Virus Surveillance System lab-based reporting shows that respiratory viruses such as coronaviruses (aside from SARS-CoV-2), RSV, and human metapneumovirus, occur in late fall, winter, and/or early spring.…”

Section: Introductionmentioning

confidence: 99%

Seasonality of respiratory, enteric, and urinary viruses revealed by wastewater genomic surveillance

Smith,

Maqsood,

Sullins

et al. 2024

mSphere

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Wastewater surveillance can reveal population-level infectious disease burden and emergent public health threats can be reliably assessed through wastewater surveillance. While molecular methods for wastewater monitoring of microorganisms have traditionally relied on PCR-based approaches, next-generation sequencing (NGS) can provide deeper insights via genomic analyses of multiple diverse pathogens. We conducted a year-long sequencing surveillance of 1,408 composite wastewater samples collected from 12 neighborhood-level access points in the greater Tempe area, Arizona, USA, and show that variation in wastewater viruses is driven by seasonal time and location. The temporal dynamics of viruses in wastewater were influenced cyclically, with the most dissimilarity between samples 23 weeks apart (i.e., winter vs summer, spring vs fall). We identified diverse urinary and enteric viruses including polyomaviruses, astroviruses, and noroviruses, and showed that their genotypes/subtypes shifted across seasons. We show that while wastewater data of certain respiratory viruses like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strongly correlate with clinical case rates, laboratory-reported case incidences were discordant with surges of high viral load in wastewater for other viruses like human coronavirus 229E. These results demonstrate the utility of wastewater sequencing for informing decision-making in public health. IMPORTANCE Wastewater surveillance can provide insights into the spread of pathogens in communities. Advances in next-generation sequencing (NGS) methodologies allow for more precise detection of viruses in wastewater. Long-term wastewater surveillance of viruses is an important tool for public health preparedness. This system can act as a public health observatory that gives real-time early warning for infectious disease outbreaks and improved response times.

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Section: Introductionmentioning

confidence: 99%

Seasonality of respiratory, enteric, and urinary viruses revealed by wastewater genomic surveillance

Smith,

Maqsood,

Sullins

et al. 2024

mSphere

View full text Add to dashboard Cite

show abstract

Putting Meta-Analysis Findings in Proper Perspective: Comment on “The Effects of Nonpharmaceutical Interventions on COVID-19 Cases, Hospitalizations, and Mortality: A Systematic Literature Review and Meta-Analysis”

Joffe,

Eappen,

Milburn

et al. 2024

AJPM Focus

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Seasonality of Respiratory, Enteric and Urinary Viruses Revealed by Wastewater Genomic Surveillance

Smith,

Maqsood,

Sullins

et al. 2024

Preprint

View full text Add to dashboard Cite

Wastewater surveillance can reveal population-level infectious disease burden and emergent public health threats can be reliably assessed through wastewater surveillance. While molecular methods for wastewater monitoring of microorganisms have traditionally relied on PCR-based approaches, next-generation sequencing can provide deeper insights via genomic analyses of multiple diverse pathogens. We conducted a year-long sequencing surveillance of 1,408 composite wastewater samples collected from 12 neighborhood-level access points in the Greater Tempe area, Arizona, USA, and show that variation in wastewater viromes is driven by seasonal time and location. Wastewater virome temporal dynamics were influenced in a cyclical manner, with the most dissimilarity between samples 23 weeks apart (i.e., winter vs summer, spring vs fall). We identified diverse urinary and enteric viruses including polyomaviruses, astroviruses and noroviruses, and showed that their genotypes/subtypes shifted across season. We show that while wastewater data of certain respiratory viruses like SARS-CoV-2 strongly correlate with clinical case rates, laboratory-reported case incidences were discordant with surges of high viral load in wastewater for other viruses like human coronavirus 229E. These results demonstrate the utility of wastewater sequencing for informing decision making in public health.

show abstract

Influence of Seasonality and Public-Health Interventions on the COVID-19 Pandemic in Northern Europe

Cited by 5 publications

References 120 publications

Seasonality of respiratory, enteric, and urinary viruses revealed by wastewater genomic surveillance

Seasonality of respiratory, enteric, and urinary viruses revealed by wastewater genomic surveillance

Putting Meta-Analysis Findings in Proper Perspective: Comment on “The Effects of Nonpharmaceutical Interventions on COVID-19 Cases, Hospitalizations, and Mortality: A Systematic Literature Review and Meta-Analysis”

Seasonality of Respiratory, Enteric and Urinary Viruses Revealed by Wastewater Genomic Surveillance

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