Influence of sarcopenia on bone health parameters in a group of eumenorrheic obese premenopausal women

Hammoud, Emneh; Toumi, Hechmi; Jacob, Christophe; Pinti, Antonio; Lespessailles, Éric; Hage, Rawad El

doi:10.1007/s00774-019-01071-3

Cited by 4 publications

(1 citation statement)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, muscle power has been shown to be a positive determinant of femoral neck (FN) and total hip BMD, FN cross-sectional area, FN cross-sectional moment of inertia and FN Z-score in 148 women between 18 and 35 years (23). Thus, it can be speculated that exercise, which improves lean mass and muscle power, has a positive effect on peak bone mass accrual, as it has been shown in previous studies (24)(25)(26)(27).…”

Section: Factors Affecting Peak Bone Mass and Early Fracture Riskmentioning

confidence: 74%

Osteoporosis in Premenopausal Women: A Clinical Narrative Review by the ECTS and the IOF

Pepe

Body

Hadji

et al. 2020

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

Abstract Context Consensus regarding diagnosis and management of osteoporosis in premenopausal women (PW) is still lacking due to few studies carried out in this population. Design The European Calcified Tissue Society and the International Osteoporosis Foundation convened a working group to produce an updated review of literature published after 2017 on this topic. Results Fragility fractures in PW are rare and mostly due to secondary osteoporosis (ie, in presence of an underlying disease such as hormonal, inflammatory, or digestive disorders). In absence of another disorder, low bone mineral density (BMD) together with fragility fractures qualifies as idiopathic osteoporosis. In contrast, low BMD alone does not necessarily represent osteoporosis in absence of bone microarchitectural abnormalities. BMD increases in PW with osteoporosis when the underlying disease is treated. For example, in celiac disease, an increase of 9% in radius trabecular volumetric density was achieved after 1 year of gluten-free diet, while anti-tumor necrosis factor alpha improved BMD in PW with inflammatory bowel diseases. In amenorrhea, including anorexia nervosa, appropriately delivered estrogen replacement therapy can also improve BMD. Alternatively, antiresorptive or anabolic therapy has been shown to improve BMD in a variety of conditions, the range of improvement (3%-16%) depending on skeletal site and the nature of the secondary cause. No studies were powered to demonstrate fracture reduction. The effects of bisphosphonates in childbearing women have been scantly studied and caution is needed. Conclusion The majority of PW with osteoporosis have an underlying disease. Specific therapy of these diseases, as well as antiresorptive and anabolic drugs, improve BMD, but without evidence of fracture reduction.