Influence of rs5065 Atrial Natriuretic Peptide Gene Variant on Coronary Artery Disease

Barbato, Emanuele; Bartúnek, Jozef; Mangiacapra, Fabio; Sciarretta, Sebastiano; Stanzione, Rosita; Delrue, Leen; Cotugno, Maria; Marchitti, Simona; Iaccarino, Guido; Sirico, Giusy; Castro, Sara Di; Evangelista, Anna; Lambrechts, Diether; Sinnaeve, Peter; Bruyne, Bernard De; Werf, Frans Van de; Janssens, S.; Fox, Keith; Wijns, William; Volpe, Massimo; Rubattu, Speranza

doi:10.1016/j.jacc.2012.02.017

Cited by 40 publications

(38 citation statements)

References 35 publications

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“…This variant resembles ANP molecules in other mammalian sepiecs such as porcine, rat and mouse, which all contain two Arg residues at the C-terminus (Koller and Goeddel, 1992). The minor C allele was associated with high risks of hypertension (Niu, 2011), stroke (Rubattu et al, 2004), coronary artery disease (Barbato et al, 2012a), and myocardial infarction (Cannone et al, 2013b). In other studies, however, such an association was not confirmed (Kato et al, 2002; Lynch et al, 2008).…”

Section: Nppa Variants In Cardiovascular Diseasementioning

confidence: 99%

Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)

Song

Wang

2015

Gene

157

101

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Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates salt-water balance and blood pressure by promoting renal sodium and water excretion and stimulating vasodilation. ANP also has an anti-hypertrophic function in the heart, which is independent of its systemic blood pressure-lowering effect. In mice, ANP deficiency causes salt-sensitive hypertension and cardiac hypertrophy. Recent studies have shown that ANP plays an important role in regulating vascular remodeling and energy metabolism. Variants in the human NPPA gene, encoding the ANP precursor, are associated with hypertension, stroke, coronary artery disease, heart failure (HF) and obesity. ANP and related peptides are used as biomarkers for heart disease. Recombinant proteins and small molecules that enhance the ANP pathway have been developed to treat patients with HF. In this review, we discuss the role of ANP in cardiovascular biology and disease.

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Section: Nppa Variants In Cardiovascular Diseasementioning

confidence: 99%

Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)

Song

Wang

2015

Gene

157

101

View full text Add to dashboard Cite

show abstract

“…Some researchers found that the minor allele G was associated with higher risk of acute coronary syndrome [11] and greater severities of CAD [12], while other studies reported that the major allele A was more prevalent in CAD patients [13] and was associated with a higher risk of hypertension, more adverse ventricular remodeling and a higher rate of hospital readmission [7]. The discrepancy could be explained by diverse patient populations and different outcomes defining CAD.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis

Tse

Pang

et al. 2017

Cardiol Res

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BackgroundPolymorphisms within natriuretic peptide (NP) genes have been associated with clinical outcomes for cardiovascular disease (CVD), but no previous study has compared the effect of these polymorphisms between men and women. This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) in key genes of the NP system and coronary angiographic outcomes, with the focus on the sexual dimorphism in the effects of these SNPs.MethodsPatients undergoing clinically indicated coronary angiography (n = 513, 328 men and 185 women) were consented and genotyped for NPPA rs5065, NPPB rs198389 and NPR2 rs10758325. Patients were stratified into having normal coronaries, non-obstructive coronary artery disease (CAD) or obstructive CAD, based on the highest stenosis in any epicardial artery. Average luminal narrowing across all four arteries was derived to represent the overall atherosclerotic burden.ResultsThe frequency of NPPB rs198389 AA genotype was significantly higher in women with obstructive CAD (P = 0.014). The same association was not observed in males. With respect to atherosclerotic burden, an association was found between the AA genotype and average luminal narrowing in women (P = 0.005), but not in men.ConclusionsThe current study identified an association between an SNP of the NPPB gene and coronary atherosclerotic burden through angiographic evidence in women but not in men. These results suggest that B-type natriuretic peptide (BNP) may have more important involvement in the development of CAD in women compared to men, and as such, genotyping of the NPPB gene may serve as a potential biomarker to identify women with high risk for CAD.

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“…However, in our current meta-analysis, the inter-gene and gene-environment interactions could not be conducted owing to the data deficiency. Last but not the least, genetic epidemiological studies show different genetic variants can predispose to different subtypes of CHD [40–42]. So subtypes of CHD, such as myocardial infarction, acute coronary syndrome and stable angina should be further analyzed.…”

Section: Discussionmentioning

confidence: 99%

Significant association between functional microRNA polymorphisms and coronary heart disease susceptibility: a comprehensive meta-analysis involving 16484 subjects

et al. 2016

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Molecular epidemiological studies suggest that microRNA polymorphisms may be associated with an increased risk of coronary heart disease (CHD). However, the results of these studies were inconsistent and inconclusive. To derive a more precise evaluation, we performed a meta-analysis focused on the associations between microRNA polymorphisms and CHD risk. PubMed, Embase, CNKI and Wanfang databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the association between microRNA-146a rs2910164, microRNA-196a2 rs11614913, microRNA-499 rs3746444 and microRNA-149 rs71428439 polymorphisms and CHD susceptibility. Heterogeneity, publication bias and sensitivity analysis were conducted to measure the robustness of our findings. A total of thirteen related studies involving 8,120 patients and 8,364 controls were analyzed. Significant associations between microRNA-146a rs2910164 polymorphism and CHD risk were observed in the total population, as well as in subgroup analysis. For microRNA-196a2 rs11614913 and microRNA-499 rs3746444, similarly increased risks were also found. In addition, no significant association was detected between microRNA-149 rs71428439 polymorphism and CHD risk. In conclusion, our meta-analyses suggest that microRNA polymorphisms may be associated with increased risk of CHD development.

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Influence of rs5065 Atrial Natriuretic Peptide Gene Variant on Coronary Artery Disease

Abstract: The MA of rs5065 ANP gene variant associates with increased susceptibility to ACS and has unfavorable prognostic value in CAD.

Cited by 40 publications

References 35 publications

Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)

Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)

Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis

Significant association between functional microRNA polymorphisms and coronary heart disease susceptibility: a comprehensive meta-analysis involving 16484 subjects

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