Influence of Reserpine on the Pituitary Content of Melanocyte-Stimulating Hormone and on Hypothalamic Factors Which Affect Its Release

Taleisnik, S.

doi:10.1677/joe.0.0420505

Cited by 9 publications

(1 citation statement)

References 20 publications

(24 reference statements)

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“…Pharmacological studies using drugs altering the function of the catecholaminergic system support the hypothesis that the PI is under inhibitory control by the hypo thalamus, with this control mediated by catecholaminergic receptors [Iturriza, 1966[Iturriza, , 1967[Iturriza, , 1969Tomatis and Taleisnik. 1968;Taleisnik et al, 1972;T hornton, 1974;Platt and Norris, 1974], Bower et al [1974] and Hadley (personal communication) suggest the control could be, more specifically, dopaminergic.…”

Section: Smithmentioning

confidence: 91%

The Effect of Apomorphine and Ergocriptine on the Release of MSH by the Pars intermedia of Rana pipiens

Smith¹

1975

Neuroendocrinology

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In an attempt to further characterize the nature of the innervation controlling melanophore-stimulating hormone (MSH) release from the pars intermedia (PI), pellets containing either apomorphine or ergocriptine were implanted in contact with the PI of the frog, and the effect on the animal’s coloration was observed. Frogs with apomorphine implants exhibited skin pallor for several hours and those with ergocriptine implants were pallid for a few days. Hypophysectomized (HX) frogs which had been darkened with MSH regained their pallor no sooner when given an injection of apomorphine than with the vehicle. However, intact dark frogs lightened when injected with apomorphine. Frogs darkened by autotransplantation of the PI to the dorsal lymph sac were lightened by an injection of apomorphine. Frogs lightened by an ergocriptine implant on the PI and then darkened by MSH did not lighten sooner than HX frogs given an injection of MSH. Ergocriptine-containing pellets implanted in the thigh took longer to produce the same effect than those implanted in contact with the PI. Since apomorphine is known to stimulate dopamine receptors in the central nervous system, and there is some evidence that ergocriptine does also, the above evidence supports the hypothesis that dopamine receptors are present in the PI.

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Section: Smithmentioning

confidence: 91%

The Effect of Apomorphine and Ergocriptine on the Release of MSH by the Pars intermedia of Rana pipiens

Smith¹

1975

Neuroendocrinology

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Effects of reserpine administration on the fine structure of the rat pars intermedia

Saland

1978

Cell Tissue Res.

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Hormone release from the pars intermedia is under inhibitory control of the hypothalamus. Control may be mediated via dopaminergic fibers which directly contact secretory cells. Administration of reserpine in vivo to adult male rats for four consecutive days results in major alternations in pars intermedia cytology. Cells show expanded areas and whorls of rough endoplasmic reticulum, as well as extensive Golgi zones with numerous dense granules. Some nerve fibers exhibit alterations in vesicle content, while others retain a more normal appearance. Freeze-fracture of glands from reserpine-treated animals provides evidence for exocytosis of granules, although such phenomena are not observed in thin sections. The ultrastructural findings suggest that reserpine alters the content of local inhibitory neurotransmitters in the pars intermedia, leading to unrestrained hormone release, followed by renewed granule synthesis.

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The effect of reserpine on the pars intermedia of the rat pituitary

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Rechardt

1985

Cell Tissue Res.

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Reserpine has a stimulatory effect on the pars intermedia of the rat pituitary, probably mediated by its action on regulatory catecholaminergic nerves. The effect of single intraperitoneal injections of 0.1-20 mg/kg b.w. of reserpine was studied in adult male rats. Reserpine at a dose of 2 mg/kg b.w. induced degranulation, orientation of the secretory granules along the cell membrane and loss of formaldehyde-chloral-induced fluorescence, accompanied by an activation of the granular endoplasmic reticulum and the Golgi apparatus. With higher doses progressive degranulation and loss of fluorescence were observed. The effect was, however, heterogeneous, and with all doses cells displaying normal ultrastructure and normal fluorescence were regularly present. To study the release of granular products (containing a different components of the pro-opiomelanocortin chain) from individual cells, formaldehyde-chloral induced fluorescence and alpha-MSH- and beta-endorphin immunoreactivies were demonstrated in consecutive sections from pituitaries of rats given 8 mg/kg body weight of reserpine 24 h before sacrifice. The results indicate coordinated release of these granular products at the cellular level after reserpine treatment.

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Influence of Reserpine on the Pituitary Content of Melanocyte-Stimulating Hormone and on Hypothalamic Factors Which Affect Its Release

Cited by 9 publications

References 20 publications

The Effect of Apomorphine and Ergocriptine on the Release of MSH by the Pars intermedia of Rana pipiens

The Effect of Apomorphine and Ergocriptine on the Release of MSH by the Pars intermedia of Rana pipiens

Effects of reserpine administration on the fine structure of the rat pars intermedia

The effect of reserpine on the pars intermedia of the rat pituitary

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