Influence of Repeated Administration of Cholecystokinin and Secretin on the Pancreas of the Rat

Fölsch, Ulrich R.; Winckler, K.; Wormsley, K. G.

doi:10.3109/00365527809181779

Cited by 146 publications

(58 citation statements)

References 15 publications

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“…It has been shown also that intra-duodenal infusion of 100 mg/kg body weight FOY-305, the same dose as that used in the present study, caused release of CCK into the portal vein of an isolated perfused duodenum, and that the CCK release was not blocked by tetrodotoxin but by vascular perfusion of a calcium-deficient solution (KANNO et al, 1979b(KANNO et al, , 1980. Furthermore, chronic treatment of CCK or caerulein is known to cause hypertrophy and hyperpyknia (MAINZ et al, 1973;YANATORI and FUJITA, 1976;FOLSCH et al, 1978;PETERSEN et al, 1978;SOLOMON et al, 1978SOLOMON et al, , 1979. The present results together with the above reported data support the view that FOY-305-induced effects on rat pancreas may be mediated mainly by endogenous CCK, though the possible participation of other humoral or neuronal factors cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

Secretory responses of hypertrophied rat pancreas induced by repeated oral administrations of a synthetic protease inhibitor.

Yonezawa

1983

Jpn.J.Physiol

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A dose of -(4-guanidinobenzoyloxy)phenylacetate methanesulfonate; 100 mg/kg body weight] was administered orally once a day for 30 days to a group of rats (FOY group). To the control group of rats, 10 ml/kg body weight of distilled water (a solvent of FOY-305) was administered in the same way. The FOY-305 administration induced hypertrophy of the pancreas : the increase in wet weight of the pancreas was significantly higher than the increase in DNA content. The administration also induced hyperpyknia in the FOY group as shown by the increased concentration of constituents (amylase, trypsinogen, and chymotrypsinogen) in the pancreas.The secretory responses of the exocrine pancreas to stimulation with cholecystokinin (CCK) were examined in vivo. The secretory responses induced by lowered doses of CCK in the FOY group were slightly greater than those in the control group, but the differences were not statistically significant. On the other hand, the responses induced by higher doses of CCK were significantly greater than those in the control group. The secretory responses to stimulation with CCK or acetylcholine (ACh) were examined further in vitro using an isolated perfused pancreas. Protein output induced by lower doses of the secretagogues (146-730 pM CCK or 10 nM ACh) was similar in the control and the FOY groups, but the output induced by higher doses of the secretagogues (1,460 pM CCK or 30-100 nM ACh) in the FOY group was significantly larger than that in the control group.The present results provided evidence that the FOY-305-induced hypertrophy and hyperpyknia of the rat pancreas coincided with potentiation of secretory responses to higher doses of the secretagogues.

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Section: Discussionmentioning

confidence: 99%

Secretory responses of hypertrophied rat pancreas induced by repeated oral administrations of a synthetic protease inhibitor.

Yonezawa

1983

Jpn.J.Physiol

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“…Gastrin is implicated in a marked proliferative action on the proximal small intestine which diminishes distally, but evidence for a trophic effect on the colon is very limited Thomas et al 2003). CCK stimulates growth of the pancreas in experimental studies (Brants & Morisset, 1976;Folsch et al 1978). However, evidence for CCK playing a major role in the growth of the GI mucosa (stomach, small bowel and colon) is limited .…”

Section: Local Effects Of Cholecystokinin and Gastrin In The Gutmentioning

confidence: 99%

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

et al. 2006

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The aim of the present review is to synthesise and summarise our recent knowledge on the involvement of cholecystokinin (CCK) and gastrin peptides and their receptors in the control of digestive functions and more generally their role in the field of nutrition in mammals. First, we examined the release of these peptides from the gut, focusing on their molecular forms, the factors regulating their release and the signalling pathways mediating their effects. Second, general physiological effects of CCK and gastrin peptides are described with regard to their specific receptors and the role of CCK on vagal mucosal afferent nerve activities. Local effects of CCK and gastrin in the gut are also reported, including gut development, gastrointestinal motility and control of pancreatic functions through vagal afferent pathways, including NO. Third, some examples of the intervention of the CCK and gastrin peptides are exposed in diseases, taking into account intervention of the classical receptor subtypes (CCK 1 and CCK 2 receptors) and their heterodimerisation as well as CCK-C receptor subtype. Finally, applications and future challenges are suggested in the nutritional field (performances) and in therapy with regards to the molecular forms or in relation with the type of receptor as well as new techniques to be utilised in detection or in therapy of disease. In conclusion, the present review underlines recent developments in this field: CCK and gastrin peptides and their receptors are the key factor of nutritional aspects; a better understanding of the mechanisms involved may increase the efficiency of the nutritional functions and the treatment of abnormalities under pathological conditions.

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“…CCK is released mainly from the I cells of the small intestine and induces gallbladder contraction and pancreatic enzyme secretion in mammals (Folsch et al 1978, Sonobe et al 1995. Furthermore, CCK is expressed in the central and peripheral nervous system and is implicated in neural functions such as food intake, sleep and memory (Crawley & Corwin 1994, Moran & Schwartz 1994.…”

Section: Introductionmentioning

confidence: 99%

Molecular and functional characterization of cionin receptors in the ascidian, Ciona intestinalis: the evolutionary origin of the vertebrate cholecystokinin/gastrin family

Sekiguchi

Ogasawara²,

Satake³

2012

Journal of Endocrinology

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Cholecystokinin (CCK) and gastrin are vertebrate brain-gut peptides featured by a sulfated tyrosine residue and a C-terminally amidated tetrapeptide consensus sequence. Cionin, identified in the ascidian, Ciona intestinalis, the closest species to vertebrates, harbors two sulfated tyrosines and the CCK/gastrin consensus tetrapeptide sequence. While a putative cionin receptor, cior, was cloned, the ligand-receptor relationship between cionin and CioR remains unidentified. Here, we identify two cionin receptors, CioR1 and CioR2, which are the aforementioned putative cionin receptor and its novel paralog respectively. Phylogenetic analysis revealed that CioRs are homologous to vertebrate CCK receptors (CCKRs) and diverged from a common ancestor in the Ciona-specific lineage. Cionin activates intracellular calcium mobilization in cultured cells expressing CioR1 or CioR2. Monosulfated and nonsulfated cionin exhibited less potent or no activity, indicating that CioRs possess pharmacological features similar to the vertebrate CCK-specific receptor CCK1R, rather than its subtype CCK2R, given that a sulfated tyrosine in CCK is required for binding to CCK1R, but not to CCK2R. Collectively, the present data reveal that CioRs share a common ancestor with vertebrate CCKRs and indicate that CCK and CCK1R form the ancestral ligand-receptor pair in the vertebrate CCK/gastrin system. Cionin is expressed in the neural complex, digestive organs, oral siphon and atrial siphons, whereas the expression of ciors was detected mainly in these tissues and the ovary. Furthermore, cioninergic neurons innervate both of the siphons. These results suggest that cionin is involved in the regulation of siphonal functions.

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Influence of Repeated Administration of Cholecystokinin and Secretin on the Pancreas of the Rat

Cited by 146 publications

References 15 publications

Secretory responses of hypertrophied rat pancreas induced by repeated oral administrations of a synthetic protease inhibitor.

Secretory responses of hypertrophied rat pancreas induced by repeated oral administrations of a synthetic protease inhibitor.

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

Molecular and functional characterization of cionin receptors in the ascidian, Ciona intestinalis: the evolutionary origin of the vertebrate cholecystokinin/gastrin family

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