Influence of Rate of Force Application During Compression on Tablet Capping

Sarkar, Srimanta; Ooi, Shing Ming; Liew, Celine Valeria; Heng, Paul Wan Sia

doi:10.1002/jps.24328

Cited by 13 publications

(6 citation statements)

References 20 publications

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“…When the effect of one compression event was studied, the other compression event was deactivated by setting a larger distance between the top and bottom punches so that the die fill passed the event without being subjected to any compression force. 14…”

Section: Tablet Preparationmentioning

confidence: 99%

“…The rate of force application (RFA) was calculated using MATLAB (R2010a; The MathWorks, Natick, MA). 14 Gaussian distribution equation (Eq. 3) was used to fit the data using the leastsquare error algorithm (r 2 close to 1).…”

Section: Compression Parametersmentioning

confidence: 99%

“…Paracetamol and lactose-based formulations have been reported to be prone to tablet failure during manufacturing. 14,19 The Heckel plot slope and the extent of stress relaxation were used as nonspecific test parameters to provide some general descriptors on the deformation mechanism of the tableting materials as shown in Figures 3a and 3b. The Heckel plots for both materials showed long quasi-linear portions pointing to prevailing plastic flow, in combination with elastic deformation.…”

Section: Compression Behavior Of Tableting Materialsmentioning

confidence: 99%

See 2 more Smart Citations

Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press

Anbalagan

Sarkar

Liew

et al. 2017

Journal of Pharmaceutical Sciences

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Section: Tablet Preparationmentioning

confidence: 99%

Section: Compression Parametersmentioning

confidence: 99%

Section: Compression Behavior Of Tableting Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press

Anbalagan

Sarkar

Liew

et al. 2017

Journal of Pharmaceutical Sciences

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“…Capping is a common mechanical defect in tablet manufacturing and formation, in which partial or complete cross-sectional segments are detached from the top or bottom face of a tablet during or after the compaction/compression process (Sarkar et al, 2015). Capping risk may be mitigated by modification of processing variables (e.g., compaction pressure and speed) or formulation changes.…”

Section: Introductionmentioning

confidence: 99%

Early detection of capping risk in pharmaceutical compacts

Vallabh

Hoag

et al. 2018

International Journal of Pharmaceutics

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Capping is a common mechanical defect in tablet manufacturing, exhibited during or after the compression process. Predicting tablet capping in terms of process variables (e.g. compaction pressure and speed) and formulation properties is essential in pharmaceutical industry. In current work, a nondestructive contact ultrasonic approach for detecting capping risk in the pharmaceutical compacts prepared under various compression forces and speeds is presented. It is shown that the extracted mechanical properties can be used as early indicators for invisible capping (prior to visible damage). Based on the analysis of X-ray cross-section images and a large set of waveform data, it is demonstrated that the mechanical properties and acoustic wave propagation characteristics is significantly modulated by the tablet's internal cracks and capping at higher compaction speeds and pressures. In addition, the experimentally extracted properties were correlated to the directly-measured porosity and tensile strength of compacts of Pearlitol®, Anhydrous Mannitol and LubriTose® Mannitol, produced at two compaction speeds and at three pressure levels. The effect compaction speed and pressure on the porosity and tensile strength of the resulting compacts is quantified, and related to the compact acoustic characteristics and mechanical properties. The detailed experimental approach and reported wave propagation data could find key applications in determining the bounds of manufacturing design spaces in the development phase, predicting capping during (continuous) tablet manufacturing, as well as online monitoring of tablet mechanical integrity and reducing batch-to-batch end-product quality variations. Disciplines Disciplines Pharmacy and Pharmaceutical Sciences Comments Comments

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“…The force the upper die experiences during this process is essentially the compression force data that can be extracted from the press and used for control. The pre-compression force station is necessary as it reduces phenomena such as capping, increases the dwell time and also causes de-aeration of the powder [34]. The main compression force station is where the actual compaction takes place.…”

Section: Compaction Processmentioning

confidence: 99%

A Validated Model for Design and Evaluation of Control Architectures for a Continuous Tablet Compaction Process

Barros¹,

Bhaskar²,

Singh³

2017

Processes

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Abstract:The systematic design of an advanced and efficient control strategy for controlling critical quality attributes of the tablet compaction operation is necessary to increase the robustness of a continuous pharmaceutical manufacturing process and for real time release. A process model plays a very important role to design, evaluate and tune the control system. However, much less attention has been made to develop a validated control relevant model for tablet compaction process that can be systematically applied for design, evaluation, tuning and thereby implementation of the control system. In this work, a dynamic tablet compaction model capable of predicting linear and nonlinear process responses has been successfully developed and validated. The nonlinear model is based on a series of transfer functions and static polynomial models. The model has been applied for control system design, tuning and evaluation and thereby facilitate the control system implementation into the pilot-plant with less time and resources. The best performing control algorithm was used in the implementation and evaluation of different strategies for control of tablet weight and breaking force. A characterization of the evaluated control strategies has been presented and can serve as a guideline for the selection of the adequate control strategy for a given tablet compaction setup. A strategy based on a multiple input multiple output (MIMO) model predictive controller (MPC), developed using the simulation environment, has been implemented in a tablet press unit, verifying the relevance of the simulation tool.

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Influence of Rate of Force Application During Compression on Tablet Capping

Cited by 13 publications

References 20 publications

Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press

Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press

Early detection of capping risk in pharmaceutical compacts

A Validated Model for Design and Evaluation of Control Architectures for a Continuous Tablet Compaction Process

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