Influence of ramiprilat and losartan on ischemia reperfusion injury in rat hearts

Safari, Fatemeh; Hajizadeh, Sohrab; Shekarforoush, Shahnaz; Bayat, Gholamreza; Foadoddini, Mohsen; Khoshbaten, Ali

doi:10.1177/1470320311426025

Cited by 10 publications

(9 citation statements)

References 35 publications

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“…There have been inconsistent results concerning the effects of angiotensin inhibition on infarct size in animal models of acute MI ( 1 , 2 , 3 , 17 , 22 , 23 , 24 , 25 , 26 , 27 ). In canine models, captopril administered after coronary occlusion reduced infarct size ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Fimasartan, a New Angiotensin Receptor Blocker, in a Porcine Model of Acute Myocardial Infarction

et al. 2015

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Cardioprotective effect of fimasartan, a new angiotensin receptor blocker (ARB), was evaluated in a porcine model of acute myocardial infarction (MI). Fifty swine were randomized to group 1 (sham, n=10), group 2 (no angiotensin-converting enzyme inhibitor [ACEI] or ARB, n=10), group 3 (perindopril 2 mg daily, n=10), group 4 (valsartan 40 mg daily, n=10), or group 5 (fimasartan 30 mg daily, n=10). Acute MI was induced by occlusion of the left anterior descending artery for 50 min. Echocardiography, single photon emission computed tomography (SPECT), and F-18 fluorodeoxyglucose cardiac positron emission tomography (PET) were performed at baseline, 1 week, and 4 weeks. Iodine-123 meta-iodobenzylguanidine (MIBG) scan was done at 6 weeks for visualization of cardiac sympathetic activity. Left ventricular function and volumes at 4 weeks were similar between the 5 groups. No difference was observed in groups 2 to 5 in SPECT perfusion defect, matched and mismatched segments between SPECT and PET at 1 week and 4 weeks. MIBG scan showed similar uptake between the 5 groups. Pathologic analysis showed similar infarct size in groups 2 to 5. Infarct size reduction was not observed with use of fimasartan as well as other ACEI and ARB in a porcine model of acute MI.Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Fimasartan, a New Angiotensin Receptor Blocker, in a Porcine Model of Acute Myocardial Infarction

et al. 2015

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“…In that study four weeks of pretreatment with losartan and ramiprilat decreased myocardial infarct size and ischemia-induced ventricular premature beats. 8 Therefore, in the current study both drugs are administered for four weeks so that we can be sure about their anti-ischemic effects. Other studies showed that angiotensin receptor blockers (ARBs) can modulate UCP in the mouse brown adipose tissue, 31 rat liver 32 and rat kidney.…”

Section: Discussionmentioning

confidence: 99%

“…8 Anesthesia was induced by sodium pentobarbital (50 mg/kg, intraperitoneally (i.p.)). Body temperature was monitored with a rectal probe and maintained at 37°C using a heating pad.…”

Section: Ir Protocols and Sample Collectionmentioning

confidence: 99%

“…5,6 Most of the experiments including our recent data published in this journal have shown that the angiotensin-converting enzyme (ACE) inhibitor ramiprilat and the angiotensin type 1 receptor blocker losartan are able to protect the myocardium against IR injury by reducing infarct size and ventricular arrhythmias even at non-hypotensive doses. 7,8 However, the key protective pathways and end effectors remain to be understood. Molecular studies can provide new insights into the early cellular mechanisms involved in myocardial responses to IR injury, and therefore may have implications for the specificity of diagnosis and treatment with these drugs.…”

Section: Introductionmentioning

confidence: 99%

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Expressional profile of cardiac uncoupling protein-2 following myocardial ischemia reperfusion in losartan- and ramiprilat-treated rats

Safari

Bayat

Shekarforoush

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Background and aims:The aim of this study was to investigate the early changes of cardiac uncoupling protein-2 (UCP2) expression following myocardial ischemia reperfusion in rats chronically treated with ramiprilat and losartan. Methods: Male Wistar rats were assigned into seven groups (six in each): intact (control); sham-operated; nontreated rats subjected to ischemia and reperfusion (IR); ramiprilat-treated rats with (Ram+IR) and without ischemia (Ram); losartan treated with (Los+IR) and without ischemia (Los). Quantitative evaluation of UCP2 mRNA was carried out using realtime reverse transcription-polymerase chain reaction (RT-PCR). Mitochondria were isolated, and protein expression was quantified by Western blotting. Results: In IR group: UCP2 protein but not mRNA level was increased in the ischemic area of the left ventricle (LV) (172% ± 26.7, p < 0.001 vs. LV of control). Following acute myocardial IR, UCP2 protein levels was increased in the ischemic area of the LV but not in RV, suggesting the local effect of ischemia on UCP2 expression. IR-induced overexpression of UCP2 was suppressed by ramiprilat and losartan. Conclusion: These findings suggest that losartan and ramiprilat can suppress UCP2 expression following myocardial IR, and by this mechanism may protect the myocardium against IR injury.

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“…Preconditioning (PC) is one of the main approaches to decrease the latter injuries. [1][2][3] Ischemic preconditioning is proved to be successive in reducing the myocardial infarction. 4,5 But as it has been mentioned, this and other techniques are not suitable in human life style.…”

Section: Short Communicationmentioning

confidence: 99%

High intensive internal training induce cardioprotection against ischemic reperfusion injury

Khoshbaten

2018

MOJAP

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Influence of ramiprilat and losartan on ischemia reperfusion injury in rat hearts

Abstract: These data indicate that losartan and ramiprilat protect the heart against ischemia/reperfusion injury independently of their hemodynamic effects but in a time-dependent manner.

Cited by 10 publications

References 35 publications

Cardioprotective Effect of Fimasartan, a New Angiotensin Receptor Blocker, in a Porcine Model of Acute Myocardial Infarction

Cardioprotective Effect of Fimasartan, a New Angiotensin Receptor Blocker, in a Porcine Model of Acute Myocardial Infarction

Expressional profile of cardiac uncoupling protein-2 following myocardial ischemia reperfusion in losartan- and ramiprilat-treated rats

High intensive internal training induce cardioprotection against ischemic reperfusion injury

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