Influence of R-plasmid mediated β-lactamase production on the therapeutic efficacy of cefoxitin and cefamandole in experimental chemotherapy

Marre, R.; Schulz, E.; Freiesleben, H

doi:10.1093/jac/6.5.633

Cited by 2 publications

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“…Of this suspension 1.5 ml was injected via the urethra into the bladder of the rats. In previous experiments it was shown that this leads to a vesicoureteric reflux, followed by local injuries in the forniceal region and subsequent inflammation (14,26,32). A reduction of the injected volume results in low infection rates; an increase of the bacterial concentration is associated with higher mortality rates (34).…”

Section: Methodsmentioning

confidence: 97%

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Contribution of cloned virulence factors from uropathogenic Escherichia coli strains to nephropathogenicity in an experimental rat pyelonephritis model

Marre¹,

Hacker²,

Henkel³

et al. 1986

Infect Immun

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Section: Methodsmentioning

confidence: 97%

“…Pyelonephritis model. The nonobstructed pyelonephritis model (26,32) was used as the in vivo assay. The rats were anesthetized with penobarbital (Nembutal; Abbott Laboratories), at a dose of 25 mg/kg of body weight administered intraperitoneally.…”

Section: Methodsmentioning

confidence: 99%

Contribution of cloned virulence factors from uropathogenic Escherichia coli strains to nephropathogenicity in an experimental rat pyelonephritis model

Marre¹,

Hacker²,

Henkel³

et al. 1986

Infect Immun

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Activity of Cefoperazone Against Ampicillin-Resistant Bacteria in Agar and Broth Dilution Tests

Kayser

Morenzoni

Homberger

1982

Antimicrob Agents Chemother

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Examination of the activity of cefoperazone against ampicillin-resistant, gramnegative bacteria in agar dilution and simultaneously in broth dilution revealed that strains could be divided into three classes: class I strains were susceptible in agar (mean minimal inhibitory concentration [MIC], 0.5 mg/liter) as well as in broth dilution (mean MIC, 1.5 mg/liter), class II strains were susceptible in agar (MIC, 0.9 mg/liter), but resistant in broth dilution (MIC, 182 mg/liter); and class III strains were highly resistant in both test systems. Among 100 randomly selected ampicillin-resistant Escherichia coli cultures, 51 belonged to class I and 49 belonged to class II. Class III E. coli strains were much rarer. Similar results were obtained with cefamandole and cephalothin, but not with six other secondand third-generation cephalosporins. MICs of cefoperazone against cultures of all three classes were influenced by initial inoculum size. The inoculum effect was greatest with class IX strains. Examination of bactericidal activity by cefoperazone showed killing of class I and class II E. coli strains and of class III strains of other genera during the first hours of incubation and regrowth after the drug was destroyed by the action of TEM P-lactamase (penicillinase). Representative class I bacteria produced 10 to 100 times less TEM 1-lactamase than did class II strains. It appeared that the quantitative difference in TEM production was the reason for the different resistance phenotypes in class I and class II strains. Salmonella and Klebsiella strains of class III produced the same amounts of TEM ,-lactamase as did class II E. coli strains. Probably, some factors other than P-lactamase contributed to the class III phenotype in these species.

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Influence of R-plasmid mediated β-lactamase production on the therapeutic efficacy of cefoxitin and cefamandole in experimental chemotherapy

Cited by 2 publications

References 0 publications

Contribution of cloned virulence factors from uropathogenic Escherichia coli strains to nephropathogenicity in an experimental rat pyelonephritis model

Contribution of cloned virulence factors from uropathogenic Escherichia coli strains to nephropathogenicity in an experimental rat pyelonephritis model

Activity of Cefoperazone Against Ampicillin-Resistant Bacteria in Agar and Broth Dilution Tests

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