Influence of Psyllium Seed Husk on Azotemia, Electrolytes, and Bowel Regulation in Patients on CAPD

Dessau, Ram Benny; Olsen, O B; Frifelt, J J; Skott, H

doi:10.1177/089686088900900426

Cited by 3 publications

(4 citation statements)

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“…12e14 Nevertheless, one small study examining the ability of psyllium husk to reduce azotemia failed to find any effect. 15 Our data support these findings, because we failed to observe any significant change in BUN or creatinine in the control group.…”

Section: Discussionsupporting

confidence: 75%

Azodyl, a synbiotic, fails to alter azotemia in cats with chronic kidney disease when sprinkled onto food

Rishniw¹,

Wynn

2011

Journal of Feline Medicine and Surgery

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The effect of probiotic therapy in chronic kidney disease (CKD) in cats is poorly defined, but gaining in popularity. However, cat owners often prefer to administer probiotics by combining them with food, rather than administering capsules intact, as is prescribed by the manufacturer. The efficacy of such non-recommended administration is unknown. In this double-blinded, controlled clinical trial, 10 cats with naturally-occurring CKD were randomized to receive either a probiotic-prebiotic combination (synbiotic) or psyllium husk (prebiotic only) for 2 months. Medications were sprinkled and mixed into food or given as a slurry. Blood urea nitrogen (BUN) and creatinine were measured twice prior to administration of medication, and then monthly for 2 months during the medication administration. Owners and clinicians were masked as to treatment. The maximal percentage change in BUN and creatinine was calculated for each cat. No differences in percentage change were detected between groups (P=0.8 for both BUN and creatinine). The synbiotic supplement used in this study, when applied to food or administered as a slurry fails to reduce azotemia in cats with CKD. Therefore, owners should not administer this synbiotic in this manner.

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Section: Discussionsupporting

confidence: 75%

Azodyl, a synbiotic, fails to alter azotemia in cats with chronic kidney disease when sprinkled onto food

Rishniw¹,

Wynn

2011

Journal of Feline Medicine and Surgery

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“…Number of patients agent, can also be used to increase fibre intake and prevent constipation. In its untreated form it is highly viscous and gels rapidly, but controlled partial enzyme hydrolysis renders it easily soluble at the pH of many foods, less viscous and with a bland flavour [10]. PHGG has been evaluated in constipated women, in a Nursing Home setting and as a treatment for Irritable Bowel Syndrome [11,12].…”

Section: Introductionmentioning

confidence: 99%

Can Increased Dietary Fibre Reduce Laxative Requirement in Peritoneal Dialysis Patients?

Sutton

Dumbleton

Allaway

2007

Journal of Renal Care

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Constipation is an important cause of technique failure and poor dialysis efficiency in Peritoneal Dialysis (PD) patients. A review of patient notes on our unit revealed 43% reported difficulties associated with constipation. A stool and laxative recording diary was sent to 126 PD patients. 46 patients reported using laxatives. All respondents using laxatives were invited to use a soluble dietary fibre supplement for 4 weeks, followed by dietary advice to see if they could achieve the same effect using high fibre foods. 23 patients entered the intervention stage of the study. 17 succeeded in replacing prescribed laxatives with the fibre supplement. 16 tried to increase their intake of high fibre foods, with 8 of these succeeding in improving their dietary intake of fibre; however only 2 were able to reduce their intake of fibre supplement. The results of the study suggest that a fibre supplement can be as effective as current laxative treatment in preventing constipation, as well as being the preferred choice of patients as many felt it improved bowel habits while not having the side effects of stimulant laxatives.

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“…Other viscous fibers such as β‐glucans and pectins, however, are highly fermentable; therefore, while they may have other positive physiological benefits, they may not help with laxation and improvement in diarrhea. Surprisingly, to our knowledge, there is only one study on the effects of psyllium husk in patients on peritoneal dialysis, where it was found that psyllium was an effective laxative 123 . Future studies should assess if psyllium husk supplementation improves constipation and diarrhea in people with CKD and kidney failure.…”

Section: Structural and Functional Gastrointestinal Changes In Ckdmentioning

confidence: 95%

“…Surprisingly, to our knowledge, there is only one study on the effects of psyllium husk in patients on peritoneal dialysis, where it was found that psyllium was an effective laxative. 123 Future studies should assess if psyllium husk supplementation improves constipation and diarrhea in people with CKD and kidney failure.…”

Section: Dietary Fibermentioning

confidence: 99%

Feeling gutted in chronic kidney disease (CKD): Gastrointestinal disorders and therapies to improve gastrointestinal health in individuals CKD, including those undergoing dialysis

Biruete

Shin

Kistler

et al. 2021

Seminars in Dialysis

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Chronic kidney disease (CKD) affects 9.1% of the population worldwide. CKD may lead to structural and functional gastrointestinal alterations, including impairment in the intestinal barrier, digestion and absorption of nutrients, motility, and changes to the gut microbiome. These changes can lead to increased gastrointestinal symptoms in people with CKD, even in early grades of kidney dysfunction. Gastrointestinal symptoms have been associated with lower quality of life and reduced nutritional status. Therefore, there has been considerable interest in improving gastrointestinal health in this clinical population. Gastrointestinal health can be influenced by lifestyle and medications, particularly in advanced grades of kidney dysfunction. Therapies focused on gastrointestinal health have been studied, including the use of probiotics, prebiotics, and synbiotics, yielding limited and conflicting results. This review summarizes the alterations in the gastrointestinal tract structure and function and provides an overview of potential nutritional interventions that kidney disease professionals can provide to improve gastrointestinal health in individuals with CKD.

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Influence of Psyllium Seed Husk on Azotemia, Electrolytes, and Bowel Regulation in Patients on CAPD

Cited by 3 publications

References 0 publications

Azodyl, a synbiotic, fails to alter azotemia in cats with chronic kidney disease when sprinkled onto food

Azodyl, a synbiotic, fails to alter azotemia in cats with chronic kidney disease when sprinkled onto food

Can Increased Dietary Fibre Reduce Laxative Requirement in Peritoneal Dialysis Patients?

Feeling gutted in chronic kidney disease (CKD): Gastrointestinal disorders and therapies to improve gastrointestinal health in individuals CKD, including those undergoing dialysis

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