Influence of Psychological Factors in Breast and Lung Cancer Risk – A Systematic Review

Pereira, Maria; Araújo, António; Simões, Mário; Costa, Catarina

doi:10.3389/fpsyg.2021.769394

Cited by 11 publications

(6 citation statements)

References 87 publications

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“…Although multivariable logistic regression results did not corroborate this association across the entire cohort, it remained evident among the premenopausal population. Nevertheless, the overall epidemiological evidence supporting an association between depression and breast cancer remains inconclusive ( 7 – 8 ). Discrepancies among study findings may be attributed to variations in lifestyle and cultural factors across countries, as well as the inclusion of age groups with differing breast cancer incidence rates.…”

Section: Discussionmentioning

confidence: 99%

Depressive Symptoms and Sleep Duration as Risk Factors for Breast Cancer — China, 2020

Liu¹,

Bao²,

Wang³

et al. 2023

China CDC Weekly

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What is already known about this topic? Psychological and lifestyle factors are known to potentially play a significant role in the development of breast cancer. However, current evidence-based studies present controversial findings on the associations between depression, sleep duration, and breast cancer risk. What is added by this report? This study investigated the potential risk factors of depressive symptoms and short sleep duration for breast cancer within the Breast Cancer Cohort Study in Chinese Women. The findings revealed that women experiencing depressive symptoms and short sleep duration exhibited a heightened risk of developing breast cancer, particularly among the older population. What are the implications for public health practice? Public policy ought to prioritize early health education interventions targeting psychological factors in order to facilitate the prevention of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Depressive Symptoms and Sleep Duration as Risk Factors for Breast Cancer — China, 2020

Liu¹,

Bao²,

Wang³

et al. 2023

China CDC Weekly

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“…Adverse experiences or traumatic stressors in childhood, adolescence, or adulthood have been widely linked to PTSD ( Kessler et al, 2010 ; Pereira et al, 2022 ; Wang, Shelton & Dwivedi, 2018 ). Child maltreatment is harm or risk of harm to a child by a caregiver’s act or omission.…”

Section: Introductionmentioning

confidence: 99%

“…It affects up to 37.5% of children exposed to maltreatment ( Alisic et al, 2014 ; Scott, Smith & Ellis, 2010 ). Other factors, such as previous trauma, gender, depressive episode (DE), and hereditary factors, have been linked to post-disaster PTSD ( Carr et al, 2013 ; Gallo et al, 2018 ; Hughes et al, 2017 ; Kessler et al, 2010 ; Li et al, 2021a ; Pereira et al, 2022 ). Individuals in high-risk disaster settings are heavily exposed, increasing the risk of developing PTSD and DE ( Fernandez et al, 2020 ; Norris et al, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean population

Castillo-Navarrete,

Vicente,

Schmidt

et al. 2023

PeerJ

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Post-traumatic stress (PTSD) disorder is a mental health condition that can occur after experiencing or witnessing a traumatic event. The 27-F earthquake that struck Chile in 2010 was one such event that had a significant impact on the mental health of the population. A study was conducted to investigate the prevalence of PTSD and its associated factors among survivors of this earthquake. The study was a longitudinal design, involving a sample of 913 patients aged 18 to 75 years who attended 10 Primary Care Centers in Concepción, Chile. The Composite International Diagnostic Interview (CIDI) was used to assess both depressive episodes (DE) and PTSD before and after the earthquake. The study also involved genotyping studies using saliva samples from the participants, specifically focusing on the Val66Met and 5-HTTLPR polymorphisms. Statistical analysis was performed to examine the association between different variables and the presence of PTSD. These variables included demographic factors, family history of psychiatric disorders, DE, childhood maltreatment experiences, and critical traumatic events related to the earthquake. The results showed that the incidence of post-earthquake PTSD was 11.06%. No significant differences were found between the groups of participants who developed post-earthquake PTSD regarding the Val66Met or 5-HTTLPR polymorphisms. However, a significant association was found between the concomitant diagnosis of DE and the development of post-earthquake PTSD. The presence of DE doubled the risk of developing post-earthquake PTSD. The number of traumatic events experienced also had a statistically significant association with an increased risk of developing post-earthquake PTSD. The study’s limitations include the potential interference of different DE subtypes, the complexity of quantifying the degree of earthquake exposure experienced by each individual, and events entailing social disruption, such as looting, that can profoundly influence distress. In conclusion, the study found that PTSD following the 27-F earthquake in Chile was associated with a concomitant diagnosis of DE and the number of traumatic events experienced. The study did not find a significant association between PTSD and the Val66Met or 5-HTTLPR polymorphisms. The researchers recommend that mental health professionals should prioritize the detection and treatment of concomitant depressive episodes and exposure to critical traumatic events in survivors of disasters. They also suggest that further research is needed to better understand the relationship between genetic factors and post-disaster PTSD.

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“…[ 1 ] In 2020, breast cancer had the highest number of new cases, nearly 2.3 million (11.7%) among an estimated 19.3 million of all cancer cases worldwide. [ 2 ] Bones are hard tissues with complex and mineralized bone matrix that can inhibit invasion by cancer cells and protect the osteocyte. [ 3 ] The bone metabolism is dynamically balanced between the formation of osteoblasts and the reabsorption of osteoclasts, [ 4 ] and disruption of the balance may result in serious diseases on the bones, such as osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐506 ameliorates breast cancer‐induced osteolytic bone metastasis via the NFATc‐1 signaling pathway

Qin

Kong

et al. 2022

J Biochem & Molecular Tox

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Breast cancer is becoming a common life-threatening disease, especially in women, along with higher incidence and mortality. MicroRNA (miR)−506 was reported to participate in breast cancer progression, while the role of miR-506 in breast cancer-induced osteolytic bone metastasis is unclear. In the present study, we found significant downregulation of miR-506 in breast cancer tissues and cell lines. Overexpression of miR-506 notably reduced the proliferative, migratory and invasive rates of MCF7 and MDA-MB-231 cells, and reduced the production of inflammatory factors IL-6 and TNF-α in MCF7 cells. Moreover, overexpression of miR-506 obviously inhibited tumor growth in an in vivo animal model. In addition, overexpression of miR-560 efficiently attenuated breast cancer-induced osteolysis in vivo, which was characterized by increased bone volume/total volume (BT/TV), trabecular number (Tb. N), and trabecular thickness (Tb. Th), as well as the reduced trabecular separation (Tb. Sp). The nuclear factor of activated T cell cytoplasmic 1 (NFATc1) was identified as a downstream target of miR-506, and overexpression of miR-506 could inhibit breast cancer progression by targeting NFATc1. Furthermore, our results showed that NFATc-1 might participate in the inhibition of miR-506 on breast cancer-induced osteolysis. In conclusion, our findings provide insights into understanding the pathogenesis of breast cancer and breast cancer-induced osteolytic bone metastasis, and miR-506 might serve as a novel biomarker for this disease.

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Influence of Psychological Factors in Breast and Lung Cancer Risk – A Systematic Review

Cited by 11 publications

References 87 publications

Depressive Symptoms and Sleep Duration as Risk Factors for Breast Cancer — China, 2020

Depressive Symptoms and Sleep Duration as Risk Factors for Breast Cancer — China, 2020

Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean population

MicroRNA‐506 ameliorates breast cancer‐induced osteolytic bone metastasis via the NFATc‐1 signaling pathway

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