Influence of proton pump inhibitors on the pathological response of rectal cancer: a multicentre study
Marcelle G Cesca,
Erika Ruiz-Garcia,
Rui Weschenfelder
et al.
Abstract:Background:The standard neoadjuvant therapy for rectal cancer involves fluoropyrimidines and radiotherapy and, most recently, total neoadjuvant therapy (TNT). A drug-drug interaction between fluoropyrimidines and proton-pump inhibitors (PPI) was suggested, with a negative impact on oncological outcomes in breast, colon and gastric cancers. Little is known about such an effect on rectal tumours. We aimed to evaluate the impact of PPI utilisation on the pathological response after chemoradiation for rectal cance… Show more
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