Influence of Protein Intake and Renal Function on Plasma Amino Acids in Patients with Renal Impairment and after Kidney Transplantation

Abstract

A group of 17 patients with chronic renal impairment and a group of 11 patients surviving for 3-7 years after kidney transplantation were examined. In all patients plasma amino acids were analyzed. The ratio of essential/nonessential amino acids, the valine/glycine ratio and Whitehead’s quotient are influenced above all by the dietary protein intake. Raised citrulline and 3-methylhistidine values were not influenced by the protein intake, while they correlate with indicators of renal function. Changes detected after kidney transplantation are analogous.

Influence of an extracellular volume expansion (ECVE) on renal amino acid- and sodium handling in patients with autosomal dominant polycystic kidney disease (ADPKD)

“…It has not been well documented whether such uremialike symptoms only influence the AA-profile at certain stages of renal function loss or whether they progressively influence the course of the disease. If the renal function is diminished, some alterations in plasma AA's tend to manifest themselves later in the course of the disease (Pechar et al, 1978). In contrast to these observations and, surprisingly, in patients who still exhibited significant reduced renal function (i.e.…”