Influence of prostaglandin E1 on the terminal vascular bed

Weiner, Richard; Kaley, Gabor

doi:10.1152/ajplegacy.1969.217.2.563

Cited by 105 publications

(37 citation statements)

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“…These results, therefore, support Hedqvist's proposal and furthermore show that antagonism of the effects of noradrenaline on smooth muscle is at least as important a homeostatic mechanism as is the reduction in noradrenaline release. This conclusion is reinforced by the results of Holmes, Horton & Main (1963) and Weiner & Kaley (1969) who showed in various preparations that prostaglandin injections or topical application diminished the effects of nerve stimulation, noradrenaline or angiotensin. Since prostaglandin release may also have a regulatory function on the sympathetic innervation of the heart Hedqvist, Stjarne & Wennmalm, 1970;Wennmalm & Stjarne, 1971) and the vas deferens (Swedin, 1971;Hedqvist & von Euler, 1972), Hedqvist's hypothesis may have a much wider application than to the sympathetic innervation of the spleen.…”

Section: Discussionmentioning

confidence: 87%

Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen

Ferreira

Moncada

Vane

1973

British J Pharmacology

120

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Summary Cat isolated spleens release prostaglandins into the venous effluent in response to stimuli such as nerve stimulation, noradrenaline and angiotensin II. The release of prostaglandins is abolished by pre‐treatment of the spleen with indomethacin (0·3–5 μg/ml). The capsular and vascular responses to the different stimuli are augmented after inhibition of prostaglandin release. The prevention of prostaglandin release, as well as the augmentation of vascular and capsular responses, are reversible after indomethacin treatment is stopped. The role of prostaglandins as modulators of the responses to several stimuli is discussed.

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Section: Discussionmentioning

confidence: 87%

Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen

Ferreira

Moncada

Vane

1973

British J Pharmacology

120

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“…Prostaglandin-E1 increased the intracortical remodeling space associated with increased vascularization [20]. Prostaglandin-E series are known to have actions on the vascular tissue [21][22][23][24], and thus the effects on the bone formation might be related to its action on the vascular system.…”

Section: Discussionmentioning

confidence: 99%

Chronic Intramedullary Infusion of Prostaglandin E2 Stimulates Bone Formation Both in the Bone Marrow and in the Periosteum.

et al. 1995

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Abstract. Prostaglandin E2 (PGE2) has a potent bone resorbing activity in vitro, but some recent studies have shown that PGE2 stimulates bone formation in vivo. The effects of PGE2 on the bone are therefore still controversial. We attempted to reveal the effects of PGE2 on bone in vivo more directly; we injected PGE2 continuously into the bone marrow and onto the periosteum and examined the local effects of PGE2 histologically or by bone densitometry. Following PGE2 infusion into the bone marrow, new bone was formed in the bone marrow around the infused site and following PGE2 infusion onto the periosteum, extensive periosteal bone formation was observed. Bone mineral content was also increased significantly in the PGE2 infused bones. The administration of cyclic AMP did not mimic the effects of PGE2. In contrast to in vitro experiments, the in vivo effect of PGE2 is predominantly to produce bone. PGE2 and 8-bromo-CAMP (8-B-cAMP) were purchased from Sasaki Chemical Co., Ltd. (Kyoto, Japan). PGE2 was dissolved in ethanol and diluted in phosphate buffered saline (PBS; pH 7.4) with 1% heat-inactivated bovine serum albumin (dilution buffer) for use. 8-bromo-cAMP was diluted in dilution buffer for use.

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“…Twothirds, one-third, and one-fourth normal saline include 90 mEq/l, 45 to 50 mEq/l, and 30 to 35 mEq/l of sodium ion, respectively. Methods Fluctuations in pH were monitored after adding 7％ sodium bicarbonate to 200 ml or 500 ml of infusion solutions containing 40 mg of PGE 1 . Infusion solutions tested were NS, ISC, Solita-T No.…”

Section: Methodsmentioning

confidence: 99%

“…4, and KN Solution 3B. Infusion solutions volumes of 40 ml or 100 ml containing 8 mg of PGE 1 were placed in a stoppered conical ‰ask. Each of these samples represented 1/5 of the original solution volume.…”

Section: Methodsmentioning

confidence: 99%

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Consideration on Prevention of Phlebitis and Venous Pain from Intravenous Prostaglandin E<sub>1</sub> Administration by Adjusting Solution pH: <i>In Vitro</i> Manipulations Affecting pH

et al. 2008

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Prostaglandin E 1 (PGE 1 ; Alprostadil Alfadex) is a potent vasodilator and inhibitor of platelet aggregation used to treat patients with peripheral vascular disease. The main adverse eŠects of intravenous PGE 1 administration, phlebitis and venous pain, arise from the unphysiologically low pH of infusion solutions. When PGE 1 infusion solutions with a pH value greater then 6 are used, phlebitis and venous pain are considered to be avoidable. Beginning with a PGE 1 infusion solution with pH greater than 6, we add the amount of 7％ sodium bicarbonate needed to bring the solution to pH 7.4 if phlebitis or venous pain develops. In the present study we established a convenient nomogram showing the relationship between the titratable acidity of various infusion solutions and the volume of 7％ sodium bicarbonate required to attain pH 7.4 for preventing the phlebitis and venous pain associated with PGE 1 infusion.

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Influence of prostaglandin E1 on the terminal vascular bed

Cited by 105 publications

References 0 publications

Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen

Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen

Chronic Intramedullary Infusion of Prostaglandin E2 Stimulates Bone Formation Both in the Bone Marrow and in the Periosteum.

Consideration on Prevention of Phlebitis and Venous Pain from Intravenous Prostaglandin E<sub>1</sub> Administration by Adjusting Solution pH: <i>In Vitro</i> Manipulations Affecting pH

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