Influence of Promethazine on Symptom-Therapy Scores for Nausea During Patient-Controlled Analgesia With Morphine

Silverman, David G.; Freilich, Jay D.; Sevarino, Ferne B.; Paige, Darcy; Preble, L.; O’Connor, Theresa

doi:10.1213/00000539-199205000-00019

Cited by 22 publications

(11 citation statements)

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“…Walder & Aitkenhead [41] found that the addition of metoclopramide to morphine ............................................................................................................................................................................................................................................. PCA had only limited effects on the incidence of postoperative nausea and vomiting and Kaufmann et al [5] found that adding metoclopramide to morphine did not influence the incidence or severity of emesis. However, Silverman et al [42] found the inclusion of promethazine with morphine PCA reduced nausea although the findings were dependent on the nausea scale used. Studies have found that the addition of droperidol (0.05-0.2 mg.ml ÿ 1 ) to morphine PCA has reduced the incidence of nausea and vomiting and, in some cases, the need for additional intramuscular anti-emetics [5,9,40,43,44].…”

Section: Giving Prophylactic Anti-emeticsmentioning

confidence: 99%

Nausea and vomiting in the postoperative patient‐controlled analgesia environment

Woodhouse

Mather

1997

Anaesthesia

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SummaryDespite common clinical opinion that patient-controlled analgesia should be renamed 'patientcontrolled nausea', there is little evidence in support of the notion that postoperative nausea and vomiting are exacerbated by the method. Indeed, data indicate that opioid-sparing techniques are not associated with less postoperative nausea and vomiting. Although some evidence suggests that certain opioids are less emetogenic than others, this too does not stand scrutiny when compared across patients, although research is still required to find whether individual patients are better treated with a particular opioid. Similarly, the emerging practice of combining anti-emetics with patient-controlled analgesia needs wider study before it can be supported. Nausea and vomiting are distressing adverse events which frequently follow surgery. The incidence of postoperative nausea and vomiting is difficult to estimate because of methodological differences between studies; however, there are reports of from 8% to 92% of postsurgical patients experiencing postoperative emesis [1]. Lerman [2] and Watcha & White [3] suggest that the incidence of postoperative nausea and vomiting has remained fairly constant for decades with Ϸ20-30% of patients suffering from these unpleasant side-effects. However, it is common to find reports of a much higher incidence in a variety of surgical populations [4][5][6][7][8][9][10]. Differentiation of opioidinduced nausea and vomiting from that of other perioperative factors, including those associated with uncontrolled pain [11], is difficult enough without complications introduced by patient-controlled analgesia (PCA) which allows patients to medicate on irregular and inconsistent bases. This review focuses on the issues associated with nausea and vomiting as encountered in the postoperative PCA environment.

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Section: Giving Prophylactic Anti-emeticsmentioning

confidence: 99%

Nausea and vomiting in the postoperative patient‐controlled analgesia environment

Woodhouse

Mather

1997

Anaesthesia

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“…In adults, contradictory information about transdermal scopolamine has been reported (11,12). Other drugs used for PONV in adults include droperidol in varying doses, metoclopramide, cyclizine or promethazine given separately or in the PCA solution (13)(14)(15)(16)(17)(18). All these drugs seem to reduce PONV, although they may also result in drowsiness.…”

Section: Discussionmentioning

confidence: 99%

Postoperative nausea and vomiting in childrenusing patient‐controlled analgesia:the effect of prophylactic intravenous dixyrazine

Kokinsky

Thornberg

Nilsson

et al. 1999

Acta Anaesthesiol Scand

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“…In this study, oral promethazine was combined with a transdermal scopolamine patch, and it was found that this combination is more effective in reducing incidence of PONV than promethazine monotherapy. 4) Promethazine in combination with morphine In two clinical trials (14,17), the effect of promethazine and morphine combination on incidence of nausea was tested. Both studies, one with adults (N = 270) aged 18 -70 years and the other with women (N = 30) aged 18 -60 years found that the use of promethazine had no effect on the incidence of nausea.…”

Section: Fujii (2008) (36)mentioning

confidence: 99%

Promethazine in the treatment of postoperative nausea and vomiting: a systematic review

Markić

Ridge

2011

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Influence of Promethazine on Symptom-Therapy Scores for Nausea During Patient-Controlled Analgesia With Morphine

Cited by 22 publications

References 0 publications

Nausea and vomiting in the postoperative patient‐controlled analgesia environment

Nausea and vomiting in the postoperative patient‐controlled analgesia environment

Postoperative nausea and vomiting in childrenusing patient‐controlled analgesia:the effect of prophylactic intravenous dixyrazine

Promethazine in the treatment of postoperative nausea and vomiting: a systematic review

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