Influence of process parameters on droplet size distribution in SPG membrane emulsification and stability of prepared emulsion droplets

Vladisavljević, Goran T.

doi:10.1016/s0376-7388(03)00212-6

Cited by 149 publications

(86 citation statements)

References 17 publications

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“…Several single-drop technologies have been developed for generating uniform droplets, such as injection of liquid through a capillary into another co-flowing immiscible fluid [3,4], penetration of dispersed phase through microfabricated parallel silicon channels [5] or interconnected channel network in microfluidic devices [6,7], and injection of dispersed phase through microporous membranes of different nature (glass, ceramic, metallic, polymeric) [8][9][10][11][12][13][14]. Production of various particulate products, such as microspheres and microcapsules, using membrane emulsification routes was recently reviewed by Vladisavljević and Williams [15].…”

Section: Introductionmentioning

confidence: 99%

Manufacture of large uniform droplets using rotating membrane emulsification

Vladisavljević

Williams

2006

Journal of Colloid and Interface Science

119

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A new rotating membrane emulsification system using a stainless steel membrane with 100 µm laser drilled pores was used to produce oil/water emulsions consisting of 2 wt. % Tween 20 as emulsifier, paraffin wax as dispersed oil phase and 0.01-0.25 wt. % Carbomer (Carbopol ETD 2050) as stabilizer. The membrane tube, 1 cm in diameter, was rotated inside a stationary glass cylinder, diameter of 3 cm, at a constant speed in the range 50-1500 rpm. The oil phase was introduced inside the membrane tube and permeated through the porous wall moving radially into the continuous phase in the form of individual droplets. Increasing the membrane rotational speed increased the wall shear stress which resulted in a smaller average droplet diameter being produced. For a constant rotational speed, the average droplet diameter increased as the stabilizer content in the continuous phase was lowered. The optimal conditions for producing uniform emulsion droplets were a Carbomer content of 0.1-0.25 wt. % and a membrane rotational speed of 350 rpm, under which the average droplet diameter was 105-107 µm and very narrow coefficients of variation of 4.8-4.9 %. A model describing the operation is described and it is concluded that the methodology holds potential as a manufacturing protocol for both coarse and fine droplets and capsules.

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Section: Introductionmentioning

confidence: 99%

Manufacture of large uniform droplets using rotating membrane emulsification

Vladisavljević

Williams

2006

Journal of Colloid and Interface Science

119

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“…SPG finds many applications as a packing for HPLC columns, a carrier of enzymes and tissue cultures, an injection needle for blood transfusion and dialysis, and especially as a high-functional dispersion and separation membrane for preparing uniform droplets and micro-bubbles [3][4][5], microfiltration of oil-in-water (O/W) emulsions and suspensions [6][7][8], etc. The microstructure of SPG is of primary importance in any application.…”

Section: Introductionmentioning

confidence: 99%

Permeability of hydrophilic and hydrophobic Shirasu-porous-glass (SPG) membranes to pure liquids and its microstructure

Vladisavljević

Shimizu²,

Nakashima

2005

Journal of Membrane Science

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• This is the author's version of a work that was accepted for publication Hydrophobic modification of membrane surface was made by surface coating with silicone resin. The results are discussed using the non-uniform capillary bundle model of membrane permeability. The mean pore tortuosity of 1.28 was kept constant over the whole range of mean pore sizes investigated. The SEM images confirmed that the geometry of pore network was similar for all SPG membranes, irrespective of their mean pore size. The span of pore size distribution ranged from 0.28 to 0.68 and the number of pores per unit cross-sectional -2-membrane area from 10 9 to 10 13 m -2 . The membrane resistance was unchanged after surface treatment with silicone resin, which means that the pores were not plugged by the resin, even in the submicron range of mean pore sizes.

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“…A more viscous oil produced smaller droplets because of the decrease of oil velocity in active microchannels. It is important to note that the particle size distribution span for soybean and MCT oil droplets was significantly lower than that for the droplets generated using Shirasu Porous Glass (SPG) membrane (span = 0.25-0.45) [34,44] or sintered alumina membrane (span = 0.42-0.56) [45]. The distribution span for n-tetradecane droplets was relatively high indicating a wide distribution, but at the higher fluxes the span values of around 0.25 were obtained (these results are not presented here).…”

Section: Effect Of Oil Viscositymentioning

confidence: 97%

Generation of highly uniform droplets using asymmetric microchannels fabricated on a single crystal silicon plate: Effect of emulsifier and oil types

2008

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Uniform droplets of soybean oil, MCT (medium-chain fatty acid triglyceride) oil and ntetradecane with a mean diameter of 26-29 m have been generated using a silicon 24  24 mm microchip consisting of 23,489 asymmetric microchannels fabricated by photolitography and deep reactive ion etching. Each microchannel consisted of a circular 10-m diameter straight hole with a length of 70 m and a 50  10 m rectangular microslot with a depth of 30 m. At the constant oil flux of 10 Lm -2 h -1 , the percent of active channels increased with increasing the oil viscosity and ranged from 4 % for n-tetradecane to 48 % for soybean oil. The size distribution span for SDS (sodium sodium dodecyl sulphate)-and Tween 20 (polyoxyethylene (20) sorbitan monolaurate)-stabilised soybean and MCT oil droplets was 0.21-022. The ability of asymmetric microchannels to generate monodisperse soybean oil droplets at the very low SDS concentration of 0.01 wt% has been demonstrated. At the SDS concentration below the CMC, the generated droplets tend to attach to the plate surface, whereas at the higher SDS concentration they detach from the plate as soon as they are formed. The agreement between the experimental and CFD (Computational Fluid Dynamics) simulation results was excellent for soybean oil and the poorest for n-tetradecane.

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Influence of process parameters on droplet size distribution in SPG membrane emulsification and stability of prepared emulsion droplets

Cited by 149 publications

References 17 publications

Manufacture of large uniform droplets using rotating membrane emulsification

Manufacture of large uniform droplets using rotating membrane emulsification

Permeability of hydrophilic and hydrophobic Shirasu-porous-glass (SPG) membranes to pure liquids and its microstructure

Generation of highly uniform droplets using asymmetric microchannels fabricated on a single crystal silicon plate: Effect of emulsifier and oil types

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