Influence of Pro- and Anti-inflammatory Cytokines during Pathogenesis Atherosclerosis: A Dynamical Approach

Adak, Asish; Devi, A. Saranya; Gupta, Praveen Kumar

doi:10.21203/rs.3.rs-1798253/v1

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…Dominant pro‐inflammatory over the anti‐inflammatory component of the immune system may favor sudden atherosclerosis progression leading to acute cardiovascular events like AMI. 55 Influenza virus can induce significant acute changes in pro‐inflammatory cytokine levels in blood and pro‐inflammatory as well as prothrombotic effects in atherosclerotic plaques which can trigger AMI onset through plaque destabilization. 56 However, there are interindividual differences in the intensity of a rapid pro‐inflammatory response which may explain the difference in the level of risk of AMI among individuals in response to an acute stimulus such as influenza.…”

Section: Discussionmentioning

confidence: 99%

“…This interplay between the immune system and AMI highlights the vital importance of understanding the intricacies of this relationship to effectively prevent and treat AMI. Dominant pro‐inflammatory over the anti‐inflammatory component of the immune system may favor sudden atherosclerosis progression leading to acute cardiovascular events like AMI 55 . Influenza virus can induce significant acute changes in pro‐inflammatory cytokine levels in blood and pro‐inflammatory as well as prothrombotic effects in atherosclerotic plaques which can trigger AMI onset through plaque destabilization 56 .…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of influenza and other acute respiratory illnesses in patients with acute myocardial infarction in Bangladesh: A cross‐sectional study

Aleem,

Chughtai,

Rahman

et al. 2024

Health Science Reports

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Background and AimsSeveral studies imply that influenza and other respiratory illnesses could lead to acute myocardial infarction (AMI), but data from low‐income countries are scarce. We investigated the prevalence of recent respiratory illnesses and confirmed influenza in AMI patients, while also exploring their relationship with infarction severity as defined by ST‐elevation MI (STEMI) or high troponin levels.MethodsThis cross‐sectional study, held at a Dhaka tertiary hospital from May 2017 to October 2018, involved AMI inpatients. The study examined self‐reported clinical respiratory illnesses (CRI) in the week before AMI onset and confirmed influenza using baseline real‐time reverse transcription polymerase chain reaction (qRT‐PCR).ResultsOf 744 patients, 11.3% reported a recent CRI, most prominently during the 2017 influenza season (35.7%). qRT‐PCR testing found evidence of influenza in 1.5% of 546 patients, with all positives among STEMI cases. Frequencies of CRI were higher in patients with STEMI and in those with high troponin levels, although these relationships were not statistically significant after adjusting for other variables. The risk of STEMI was significantly greater during influenza seasons in the unadjusted analysis (relative risk: 1.09, 95% confidence interval [CI]: 1.02–1.18), however, this relationship was not significant in the adjusted analysis (adjusted relative risk: 1.03, 95% CI: 0.91–1.16).ConclusionIn Bangladesh, many AMI patients had a recent respiratory illness history, with some showing evidence of influenza. However, these illnesses showed no significant relationship to AMI severity. Further research is needed to understand these relationships better and to investigate the potential benefits of infection control measures and influenza vaccinations in reducing AMI incidence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of influenza and other acute respiratory illnesses in patients with acute myocardial infarction in Bangladesh: A cross‐sectional study

Aleem,

Chughtai,

Rahman

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…This interplay between the immune system and AMI highlights the vital importance of understanding the intricacies of this relationship in order to effectively prevent and treat AMI. Dominant pro-inflammatory over the anti-inflammatory component of the immune system may favor sudden atherosclerosis progression leading to acute cardiovascular events like AMI (53). Influenza virus can induce significant acute changes in pro-inflammatory cytokine levels in blood and pro-inflammatory as well as prothrombotic effects in atherosclerotic plaques which can trigger AMI onset through plaque destabilization (54).…”

Section: Risk Of Stemi During Influenza Season Compared To Non-influe...mentioning

confidence: 99%

Prevalence of influenza and other acute respiratory illnesses in patients with acute myocardial infarction in Bangladesh: a cross-sectional study

Aleem

Chughtai

Rahman

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Several studies imply that influenza and other respiratory illness could lead to acute myocardial infarction (AMI), but data from low-income countries are scarce. We investigated the prevalence of recent respiratory illnesses and confirmed influenza in AMI patients, while also exploring their relationship with infarction severity as defined by ST-elevation MI (STEMI) or high troponin levels. Methods: This cross-sectional study, held at a Dhaka tertiary hospital from May 2017 to October 2018, involved AMI inpatients. The study examined self-reported clinical respiratory illnesses (CRI) in the week before AMI onset and confirmed influenza using baseline qRT-PCR. Results: Of 744 patients, 11.3% reported a recent CRI, most prominently during the 2017 influenza season (35.7%). qRT-PCR testing found evidence of influenza in 1.5% of 546 patients, with all positives among STEMI cases. Frequencies of CRI were higher in patients with STEMI and in those with high troponin levels, although these associations were not statistically significant after adjusting for other variables. The risk of STEMI was significantly greater during influenza seasons in unadjusted analysis (RR: 1.09, 95% CI: 1.02- 1.18), however, this relationship was not significant in the adjusted analysis (aRR: 1.03, 95% CI: 0.91- 1.16). Conclusions: In Bangladesh, many AMI patients had a recent respiratory illness history, with some showing evidence of influenza. However, these illnesses showed no significant relationship to AMI severity. Further research is needed to understand these associations better and to investigate the potential benefits of infection control measures and influenza vaccinations in reducing AMI incidence.

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Influence of Pro- and Anti-inflammatory Cytokines during Pathogenesis Atherosclerosis: A Dynamical Approach

Cited by 2 publications

References 13 publications

Prevalence of influenza and other acute respiratory illnesses in patients with acute myocardial infarction in Bangladesh: A cross‐sectional study

Prevalence of influenza and other acute respiratory illnesses in patients with acute myocardial infarction in Bangladesh: A cross‐sectional study

Prevalence of influenza and other acute respiratory illnesses in patients with acute myocardial infarction in Bangladesh: a cross-sectional study

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