The permeability of deep rock is closely related to the stability and safety of underground engineering. The rocks in deep stratum are mostly with high stress and high osmotic pressure. Therefore, it is necessary to consider the coupling effect between porewater pressure and in situ stress on rock mass. A series of triaxial cyclic loading and unloading experiments under hydraulic-mechanics coupling conditions are carried out to studied the mechanical and hydraulic properties of granite in the depth of 1300 m to 1500 m. Especially, the effect of the disturbance on the permeability of fractured rocks are investigated by unloaded the confining pressure. Tests results presented that the stress-strain curves of deep granite showed typical brittle characteristics. The principal stress of granite exhibited a linear relationship under the high confining pressure of 34-40 MPa and high osmotic pressure of 13-15 MPa. Dissipated energy of the rock decreased to a relatively low level after 2-3 loading cycles and then slowly increased. Permeability showed a decreasing trend as the loading and unloading cycles increase. Finally, acoustic emission technology was used to monitor the fracture evolution in rocks, the acoustic emission signal released as the fractures develop and energy dissipated. The results would provide basic data for the exploitation and excavation in the deep galleries.