Influence of Preoperative Muscle Mass Assessed by Computed Tomography on Prognosis After Liver Transplantation

Which preoperative assessment modalities best identify patients who are suitable for enhanced recovery after liver transplantation? A systematic review of the literature and expert panel recommendations

“…In addition, 15 more studies were included after the review performed by the panel. In the end, 22 studies were included in the review 15–36 …”

“…As stated in Methods, no study directly assessed the question of which pre-LT modality identifies patients suitable for ERAS, so in the end we evaluated 22 studies that assessed different preoperative assessment modalities and their impact on post-LT outcomes. Regarding the pre-transplant assessment modalities evaluated in the studies, 4 studies evaluated cardiopulmonary capacity by different means including 6-minute walking test and cardiopulmonary exercise 8 testing (CPET) (15)(16)(17)(18) , 7 studies investigated physical function by using different frailty metrics or physiological scoring systems (19)(20)(21)(22)(23)(24)(25) , and 10 utilized different quantitative morphomics modalities to estimate muscle mass and composition (27)(28)(29)(30)(31)(32)(33)(34)(35)(36) . Finally, one study included quantitative morphomics for sarcopenia in addition to a frailty assessment (26) .…”

“…Regarding the pretransplant assessment modalities evaluated in the studies, four studies evaluated cardiopulmonary capacity by different means including 6-min walking test and cardiopulmonary exercise testing (CPET), [15][16][17][18] seven studies investigated physical function by using different frailty metrics or physiological scoring systems, [19][20][21][22][23][24][25] and 10 utilized different quantitative morphomics modalities to estimate muscle mass and composition. [27][28][29][30][31][32][33][34][35][36] Finally, one study included quantitative morphomics for sarcopenia in addition to a frailty assessment. 26 With respect to post-transplant outcomes, most studies investigated intensive care unit (ICU) or hospitalization length of stay (LOS), eight studies evaluated (up to 90-day) post-transplant mortality, and five studies looked at respiratory complications.…”

Radiological Assessment of Sarcopenia and Its Clinical Impact in Patients with Hepatobiliary, Pancreatic, and Gastrointestinal Diseases: A Comprehensive Review

“…In this subgroup, there were 20 retrospective studies (4,168 patients) that assessed outcomes of sarcopenia in patients who underwent liver transplantation or had been waitlisted for the transplant procedure ( Table 5 ). 9 11 12 19 41 52 57 60 70 78 84 87 94 96 97 113 120 133 138 139…”